TY - JOUR
T1 - Does patient sex influence cartilage surgery outcome?
T2 - Analysis of results at 5-year follow-up in a large cohort of patients treated with matrix-assisted autologous chondrocyte transplantation
AU - Filardo, Giuseppe
AU - Kon, Elizaveta
AU - Andriolo, Luca
AU - Vannini, Francesca
AU - Buda, Roberto
AU - Ferruzzi, Alberto
AU - Giannini, Sandro
AU - Marcacci, Maurilio
PY - 2013/8
Y1 - 2013/8
N2 - Background: Sexual dimorphism in humans has already been documented at different levels, and preliminary findings also suggest the importance of patient sex on clinical outcome in the treatment of cartilage lesions. Purpose: To document and analyze the influence of sex on clinical outcome in a large cohort of patients treated with a cartilage regenerative procedure for knee chondral lesions and prospectively followed at midterm follow-up. Study Design: Cohort study; Level of evidence, 3. Methods: A total of 250 knees were treated with matrix-assisted autologous chondrocyte transplantation (MACT) and prospectively evaluated with International Knee Documentation Committee (IKDC), EuroQol visual analog scale (EQ-VAS), and Tegner scores at 1-, 2-, and minimum 5-year follow-ups to compare results obtained in men and women. The lesions were focal International Cartilage Repair Society grade III-IV chondral knee defects involving femoral condyles, trochleae, and patellae. Two homogeneous groups of 56 male patients and 56 female patients were then selected by a blinded statistician for a matched-pair analysis. Results: A statistically significant improvement in all the scores in both men and women was observed in the general population. The IKDC subjective score showed better results for men at all follow-up times: at 5 years, the mean IKDC subjective score was 79.5 ± 18.6 versus 64.3 ± 20.2 for men and women, respectively (P
AB - Background: Sexual dimorphism in humans has already been documented at different levels, and preliminary findings also suggest the importance of patient sex on clinical outcome in the treatment of cartilage lesions. Purpose: To document and analyze the influence of sex on clinical outcome in a large cohort of patients treated with a cartilage regenerative procedure for knee chondral lesions and prospectively followed at midterm follow-up. Study Design: Cohort study; Level of evidence, 3. Methods: A total of 250 knees were treated with matrix-assisted autologous chondrocyte transplantation (MACT) and prospectively evaluated with International Knee Documentation Committee (IKDC), EuroQol visual analog scale (EQ-VAS), and Tegner scores at 1-, 2-, and minimum 5-year follow-ups to compare results obtained in men and women. The lesions were focal International Cartilage Repair Society grade III-IV chondral knee defects involving femoral condyles, trochleae, and patellae. Two homogeneous groups of 56 male patients and 56 female patients were then selected by a blinded statistician for a matched-pair analysis. Results: A statistically significant improvement in all the scores in both men and women was observed in the general population. The IKDC subjective score showed better results for men at all follow-up times: at 5 years, the mean IKDC subjective score was 79.5 ± 18.6 versus 64.3 ± 20.2 for men and women, respectively (P
KW - cartilage regeneration
KW - gender
KW - knee
KW - matrix-assisted autologous chondrocyte transplantation
KW - sex
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U2 - 10.1177/0363546513480780
DO - 10.1177/0363546513480780
M3 - Article
C2 - 23857885
AN - SCOPUS:84881401732
VL - 41
SP - 1827
EP - 1834
JO - American Journal of Sports Medicine
JF - American Journal of Sports Medicine
SN - 0363-5465
IS - 8
ER -