Abstract
There is scarce information regarding the prognostic utility of peak exercise oxygen pulse (peak O2 pulse), a surrogate for stroke volume, in patients with heart failure (HF). From May 1994 to November 2007, 998 patients with HF underwent cardiopulmonary exercise testing. The ability of peak oxygen uptake (VO2) and peak O2 pulse to predict cardiac events was examined. Peak O2 pulse was calculated by dividing peak VO2 by heart rate at the time peak VO2 was achieved and was expressed in both milliliters per beat and as a percentage achieved of the age-predicted value. There were 212 cardiac events (176 deaths, 26 transplantations, and 10 left ventricular assist device implantations) over a mean of 28 ± 26 months of follow-up. Peak VO2 and age-predicted peak O2 pulse were demonstrated by univariate and multivariate Cox regression analyses to be independent predictors of mortality (p 2 and age-predicted peak O2 pulse (-1/min-1] and 2 pulse also predicted mortality in patients in the intermediate range of peak VO2 (10 to 14 (mL/kg-1/min-1)). The 3-year mortality rate for patients in this range who had age-predicted peak O2 pulse values 2 -1/min-1). In conclusion, age-predicted peak O2 pulse was a strong and independent predictor of cardiac mortality and complemented peak VO2 in predicting risk in patients with HF.
| Original language | English |
|---|---|
| Pages (from-to) | 554-558 |
| Number of pages | 5 |
| Journal | The American Journal of Cardiology |
| Volume | 104 |
| Issue number | 4 |
| DOIs | |
| Publication status | Published - Aug 15 2009 |
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ASJC Scopus subject areas
- Cardiology and Cardiovascular Medicine
Cite this
Does Peak Oxygen Pulse Complement Peak Oxygen Uptake in Risk Stratifying Patients With Heart Failure? / Oliveira, Ricardo B.; Myers, Jonathan; Araújo, Claudio Gil S; Arena, Ross; Mandic, Sandra; Bensimhon, Daniel; Abella, Joshua; Chase, Paul; Guazzi, Marco; Brubaker, Peter; Moore, Brian; Kitzman, Dalane; Peberdy, Mary Ann.
In: The American Journal of Cardiology, Vol. 104, No. 4, 15.08.2009, p. 554-558.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Does Peak Oxygen Pulse Complement Peak Oxygen Uptake in Risk Stratifying Patients With Heart Failure?
AU - Oliveira, Ricardo B.
AU - Myers, Jonathan
AU - Araújo, Claudio Gil S
AU - Arena, Ross
AU - Mandic, Sandra
AU - Bensimhon, Daniel
AU - Abella, Joshua
AU - Chase, Paul
AU - Guazzi, Marco
AU - Brubaker, Peter
AU - Moore, Brian
AU - Kitzman, Dalane
AU - Peberdy, Mary Ann
PY - 2009/8/15
Y1 - 2009/8/15
N2 - There is scarce information regarding the prognostic utility of peak exercise oxygen pulse (peak O2 pulse), a surrogate for stroke volume, in patients with heart failure (HF). From May 1994 to November 2007, 998 patients with HF underwent cardiopulmonary exercise testing. The ability of peak oxygen uptake (VO2) and peak O2 pulse to predict cardiac events was examined. Peak O2 pulse was calculated by dividing peak VO2 by heart rate at the time peak VO2 was achieved and was expressed in both milliliters per beat and as a percentage achieved of the age-predicted value. There were 212 cardiac events (176 deaths, 26 transplantations, and 10 left ventricular assist device implantations) over a mean of 28 ± 26 months of follow-up. Peak VO2 and age-predicted peak O2 pulse were demonstrated by univariate and multivariate Cox regression analyses to be independent predictors of mortality (p 2 and age-predicted peak O2 pulse (-1/min-1] and 2 pulse also predicted mortality in patients in the intermediate range of peak VO2 (10 to 14 (mL/kg-1/min-1)). The 3-year mortality rate for patients in this range who had age-predicted peak O2 pulse values 2 -1/min-1). In conclusion, age-predicted peak O2 pulse was a strong and independent predictor of cardiac mortality and complemented peak VO2 in predicting risk in patients with HF.
AB - There is scarce information regarding the prognostic utility of peak exercise oxygen pulse (peak O2 pulse), a surrogate for stroke volume, in patients with heart failure (HF). From May 1994 to November 2007, 998 patients with HF underwent cardiopulmonary exercise testing. The ability of peak oxygen uptake (VO2) and peak O2 pulse to predict cardiac events was examined. Peak O2 pulse was calculated by dividing peak VO2 by heart rate at the time peak VO2 was achieved and was expressed in both milliliters per beat and as a percentage achieved of the age-predicted value. There were 212 cardiac events (176 deaths, 26 transplantations, and 10 left ventricular assist device implantations) over a mean of 28 ± 26 months of follow-up. Peak VO2 and age-predicted peak O2 pulse were demonstrated by univariate and multivariate Cox regression analyses to be independent predictors of mortality (p 2 and age-predicted peak O2 pulse (-1/min-1] and 2 pulse also predicted mortality in patients in the intermediate range of peak VO2 (10 to 14 (mL/kg-1/min-1)). The 3-year mortality rate for patients in this range who had age-predicted peak O2 pulse values 2 -1/min-1). In conclusion, age-predicted peak O2 pulse was a strong and independent predictor of cardiac mortality and complemented peak VO2 in predicting risk in patients with HF.
UR - http://www.scopus.com/inward/record.url?scp=67849106938&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=67849106938&partnerID=8YFLogxK
U2 - 10.1016/j.amjcard.2009.04.022
DO - 10.1016/j.amjcard.2009.04.022
M3 - Article
C2 - 19660611
AN - SCOPUS:67849106938
VL - 104
SP - 554
EP - 558
JO - American Journal of Cardiology
JF - American Journal of Cardiology
SN - 0002-9149
IS - 4
ER -