Does Pringle maneuver affect survival in patients with colorectal liver metastases?

Alessandro Ferrero, Nadia Russolillo, Luca Viganò, Roberto Lo Tesoriere, Andrea Muratore, Lorenzo Capussotti

Research output: Contribution to journalArticle

Abstract

Background: The purpose of this original article was to evaluate the impact of the Pringle maneuver on the survival of patients with colorectal liver metastases. Methods: Eighty patients with colorectal liver metastases were randomized to undergo hepatectomy with (39 patients, HPC group) or without (41 patients, NHPC group) pedicle clamping. Results: The two groups were homogeneous. Mortality and morbidity rates were similar. Blood transfusions rates were higher in HPC group (p = 0.010). Median follow-up was 67.1 ± 20 months in the HPC group and 77.5 ± 16.6 months in the other group (p = 0.07). Overall survival at 1, 3, and 5 years was 100%, 86.1%, and 49.4% in HPC group vs. 92.6%, 65.8%, and 48.2% in NHPC group (p = 0.704). Disease-free survival was similar between the two groups: 1-, 3- and 5-year survival rates were 85.7%, 51.4%, and 34.3% in the HPC group vs. 84%, 51.5%, and 37.9% in NHPC group (p = 0.943). The incidence of hepatic recurrence was similar in the two groups (p = 0.506). Median time to hepatic recurrence was similar in the two groups (p = 0.482). Overall and disease-free survival rates were similar even when the Pringle maneuver was longer than 45 min (p = 0.571 and 0.948) and in patients with liver steatosis (p = 0.779 and 0.412). Conclusions: The Pringle maneuver does not seem to affect the survival of patients with liver metastases.

Original languageEnglish
Pages (from-to)2418-2425
Number of pages8
JournalWorld Journal of Surgery
Volume34
Issue number10
DOIs
Publication statusPublished - Oct 2010

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Neoplasm Metastasis
Survival
Liver
Disease-Free Survival
Survival Rate
Recurrence
Hepatectomy
Fatty Liver
Constriction
Blood Transfusion
Morbidity
Mortality
Incidence

ASJC Scopus subject areas

  • Surgery

Cite this

Ferrero, A., Russolillo, N., Viganò, L., Lo Tesoriere, R., Muratore, A., & Capussotti, L. (2010). Does Pringle maneuver affect survival in patients with colorectal liver metastases? World Journal of Surgery, 34(10), 2418-2425. https://doi.org/10.1007/s00268-010-0682-2

Does Pringle maneuver affect survival in patients with colorectal liver metastases? / Ferrero, Alessandro; Russolillo, Nadia; Viganò, Luca; Lo Tesoriere, Roberto; Muratore, Andrea; Capussotti, Lorenzo.

In: World Journal of Surgery, Vol. 34, No. 10, 10.2010, p. 2418-2425.

Research output: Contribution to journalArticle

Ferrero, A, Russolillo, N, Viganò, L, Lo Tesoriere, R, Muratore, A & Capussotti, L 2010, 'Does Pringle maneuver affect survival in patients with colorectal liver metastases?', World Journal of Surgery, vol. 34, no. 10, pp. 2418-2425. https://doi.org/10.1007/s00268-010-0682-2
Ferrero, Alessandro ; Russolillo, Nadia ; Viganò, Luca ; Lo Tesoriere, Roberto ; Muratore, Andrea ; Capussotti, Lorenzo. / Does Pringle maneuver affect survival in patients with colorectal liver metastases?. In: World Journal of Surgery. 2010 ; Vol. 34, No. 10. pp. 2418-2425.
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abstract = "Background: The purpose of this original article was to evaluate the impact of the Pringle maneuver on the survival of patients with colorectal liver metastases. Methods: Eighty patients with colorectal liver metastases were randomized to undergo hepatectomy with (39 patients, HPC group) or without (41 patients, NHPC group) pedicle clamping. Results: The two groups were homogeneous. Mortality and morbidity rates were similar. Blood transfusions rates were higher in HPC group (p = 0.010). Median follow-up was 67.1 ± 20 months in the HPC group and 77.5 ± 16.6 months in the other group (p = 0.07). Overall survival at 1, 3, and 5 years was 100{\%}, 86.1{\%}, and 49.4{\%} in HPC group vs. 92.6{\%}, 65.8{\%}, and 48.2{\%} in NHPC group (p = 0.704). Disease-free survival was similar between the two groups: 1-, 3- and 5-year survival rates were 85.7{\%}, 51.4{\%}, and 34.3{\%} in the HPC group vs. 84{\%}, 51.5{\%}, and 37.9{\%} in NHPC group (p = 0.943). The incidence of hepatic recurrence was similar in the two groups (p = 0.506). Median time to hepatic recurrence was similar in the two groups (p = 0.482). Overall and disease-free survival rates were similar even when the Pringle maneuver was longer than 45 min (p = 0.571 and 0.948) and in patients with liver steatosis (p = 0.779 and 0.412). Conclusions: The Pringle maneuver does not seem to affect the survival of patients with liver metastases.",
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AU - Muratore, Andrea

AU - Capussotti, Lorenzo

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N2 - Background: The purpose of this original article was to evaluate the impact of the Pringle maneuver on the survival of patients with colorectal liver metastases. Methods: Eighty patients with colorectal liver metastases were randomized to undergo hepatectomy with (39 patients, HPC group) or without (41 patients, NHPC group) pedicle clamping. Results: The two groups were homogeneous. Mortality and morbidity rates were similar. Blood transfusions rates were higher in HPC group (p = 0.010). Median follow-up was 67.1 ± 20 months in the HPC group and 77.5 ± 16.6 months in the other group (p = 0.07). Overall survival at 1, 3, and 5 years was 100%, 86.1%, and 49.4% in HPC group vs. 92.6%, 65.8%, and 48.2% in NHPC group (p = 0.704). Disease-free survival was similar between the two groups: 1-, 3- and 5-year survival rates were 85.7%, 51.4%, and 34.3% in the HPC group vs. 84%, 51.5%, and 37.9% in NHPC group (p = 0.943). The incidence of hepatic recurrence was similar in the two groups (p = 0.506). Median time to hepatic recurrence was similar in the two groups (p = 0.482). Overall and disease-free survival rates were similar even when the Pringle maneuver was longer than 45 min (p = 0.571 and 0.948) and in patients with liver steatosis (p = 0.779 and 0.412). Conclusions: The Pringle maneuver does not seem to affect the survival of patients with liver metastases.

AB - Background: The purpose of this original article was to evaluate the impact of the Pringle maneuver on the survival of patients with colorectal liver metastases. Methods: Eighty patients with colorectal liver metastases were randomized to undergo hepatectomy with (39 patients, HPC group) or without (41 patients, NHPC group) pedicle clamping. Results: The two groups were homogeneous. Mortality and morbidity rates were similar. Blood transfusions rates were higher in HPC group (p = 0.010). Median follow-up was 67.1 ± 20 months in the HPC group and 77.5 ± 16.6 months in the other group (p = 0.07). Overall survival at 1, 3, and 5 years was 100%, 86.1%, and 49.4% in HPC group vs. 92.6%, 65.8%, and 48.2% in NHPC group (p = 0.704). Disease-free survival was similar between the two groups: 1-, 3- and 5-year survival rates were 85.7%, 51.4%, and 34.3% in the HPC group vs. 84%, 51.5%, and 37.9% in NHPC group (p = 0.943). The incidence of hepatic recurrence was similar in the two groups (p = 0.506). Median time to hepatic recurrence was similar in the two groups (p = 0.482). Overall and disease-free survival rates were similar even when the Pringle maneuver was longer than 45 min (p = 0.571 and 0.948) and in patients with liver steatosis (p = 0.779 and 0.412). Conclusions: The Pringle maneuver does not seem to affect the survival of patients with liver metastases.

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