Does PSA reduction after antibiotic therapy permits postpone prostate biopsy in asymptomatic men with PSA levels between 4 and 10ng/mL?

W. F S Busato, G. L. Almeida, Jamylle Geraldo, F. S. Busato

Research output: Contribution to journalArticlepeer-review

Abstract

Purpose: We investigated the effect of antibiotics on PSA in asymptomatic patients with mild PSA elevation.Materials and Methods: We prospectively evaluated, in a non-randomized design, 106 asymptomatic patients with PSA of 4-10ng/mL, with a negative digital rectal examination and with no urinary tract infection evidence for 2 years. Patients were divided into two groups: those treated with antibiotics for 3 weeks (G1) and those who were not treated (G2). PSA was taken six weeks after and prostate biopsy was performed in all patients. Results: PCa was diagnosed in 25 of 106 patients (23.6%): 16 (25.0%) in G1 and 9(21.4%) in G2 (p>0.05). PSA normalization was experienced in 24.5%. In G1, PSA returned to

Original languageEnglish
Pages (from-to)329-336
Number of pages8
JournalInternational Braz J Urol
Volume41
Issue number2
DOIs
Publication statusPublished - 2015

Keywords

  • Antibiotics
  • Biopsy
  • Prostate cancer
  • Prostatic-specific antigen
  • Screening

ASJC Scopus subject areas

  • Urology
  • Medicine(all)

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