Does surgery have a role in the treatment of local relapses of non-metastatic rhabdomyosarcoma?

Federica de Corti, Gianni Bisogno, Patrizia Dall'Igna, Andrea Ferrari, Piero Buffa, Angela de Paoli, Giovanni Cecchetto

Research output: Contribution to journalArticle

Abstract

Purpose: Patients with non-metastatic rhabdomyosarcoma (RMS) have a cure rate of 50-90%, but up to one-third of them experience mostly a local recurrence. Second-line treatment is not standardized as for newly diagnosed tumors. We evaluated the role of surgery on local relapses in a series of patients with RMS. Methods: This retrospective analysis involves 70 patients enrolled in two consecutives Italian Studies, RMS88 and RMS96, who presented local recurrence. After relapse, 40/70 underwent a surgical excision (Surgery Group, SG), that was demolitive in 10/40; 24/40 had radiotherapy, 16/40 did not receive radiotherapy or data are not known. Thirty patients out of 70 did not receive any surgical treatment (No-Surgery Group, NSG), and 20/30 received radiotherapy. Results: Overall survival (OS) after local relapse was 41.6% (mean follow-up 59 months, range 1-226). OS of SG patients was 54% versus 24.7% of the NSG patients (P=0.0117). Furthermore, OS among the SG was 61.4% with and 41.8% without radiotherapy, and 37.1% with and 0% without radiotherapy among the NSG (P

Original languageEnglish
Pages (from-to)1261-1265
Number of pages5
JournalPediatric Blood and Cancer
Volume57
Issue number7
DOIs
Publication statusPublished - Dec 15 2011

Keywords

  • Local relapse
  • RMS
  • Surgery

ASJC Scopus subject areas

  • Oncology
  • Pediatrics, Perinatology, and Child Health
  • Hematology

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    de Corti, F., Bisogno, G., Dall'Igna, P., Ferrari, A., Buffa, P., de Paoli, A., & Cecchetto, G. (2011). Does surgery have a role in the treatment of local relapses of non-metastatic rhabdomyosarcoma? Pediatric Blood and Cancer, 57(7), 1261-1265. https://doi.org/10.1002/pbc.23225