Does teno torque virus induce autoimmunity after hematopoietic stem cell transplantation? a case report

Natalia Maximova, Antonio Pizzol, Giovanna Ferrara, Alessandra Maestro, Paolo Tamaro

Research output: Contribution to journalArticlepeer-review

Abstract

Teno Torque virus, member of the family of Anelloviridae, has been associated with many autoimmune diseases such as idiopathic hepatitis, systemic lupus erythematosus, and multiple sclerosis. Its viral load tends to be higher in the bone marrow and in tissues with high turnover rate. We report here a case of an 11-month-old infant affected by acute myeloid leukemia who underwent hematopoietic stem cell transplantation, and after 6 months had autoimmune hepatitis and atopic dermatitis. Extremely high-cytokine IP-10 and eotaxin levels were found in her sera, and serological tests and RT-PCR for viruses showed positive results exclusively for Teno Torque virus.

Original languageEnglish
Pages (from-to)e194-e197
JournalJournal of Pediatric Hematology/Oncology
Volume37
Issue number3
DOIs
Publication statusPublished - Apr 7 2015

Keywords

  • autoimmunity
  • HSCT
  • tacrolimus
  • TTV

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Oncology
  • Hematology
  • Medicine(all)

Fingerprint Dive into the research topics of 'Does teno torque virus induce autoimmunity after hematopoietic stem cell transplantation? a case report'. Together they form a unique fingerprint.

Cite this