Does the age of onset of growth hormone deficiency affect cardiac performance? A radionuclide angiography study

Annamaria Colao, Alberto Cuocolo, Carolina Di Somma, Gaetana Cerbone, Anna Maria Della Morte, Rosario Pivonello, Emanuele Nicolai, Marco Salvatore, Gaetano Lombardi

Research output: Contribution to journalArticle

Abstract

BACKGROUND: GH and IGF-I seem to play a relevant role in cardiac development and performance. Longstanding GH deficiency (GHD) causes several abnormalities in cardiac structure and performance which ultimately determine an increased cardiovascular morbidity and mortality. OBJECTIVE: To investigate whether the age of onset of GHD plays a role in determining the negative effects on the heart. DESIGN: Open cross-sectional PATIENTS: 55 patients with adulthood-onset GHD and 36 healthy sex- and age-matched controls. Patients and controls were divided into 2 groups in line with age: 32 patients and 16 controls, were aged ≤ 35 years (young); while 23 patients and 20 controls were aged between 36 and 60 years (middle-aged). The estimated disease duration was similar in young (6.7 ± 0.5 years) and middle-aged patients (8.1 ± 1.2 years, P = 0.2). STUDY PROTOCOL: All subjects underwent ECG, blood pressure and heart rate measurement, plasma IGF-I level assay, and equilibrium radionuclide angiography. RESULTS: Plasma IGF-I levels were significantly lower in patients than in controls (P <0.0001). When considered as a whole, no difference in systolic (SBP) and diastolic blood pressure (DBP) at peak exercise was found between patients and controls. However, a significant decrease of SBP at rest was found in young patients as compared to age-matched controls (P = 0.009), while a significant increase of DBP at rest was found in middle-aged patients as compared to age-matched controls (P = 0.03). In addition, in young patients, both resting (P = 0.02) and exercise heart rate (P = 0.01) were significantly lower than in controls. Diastolic filling when measured as end-diastolic volume (EVD/sec), was significantly reduced in middle-aged patients (P = 0.04). An impaired peak filling rate (PFR) (2 = 5.3, P = 0.02): 17 young (53.1%) and 13 middle-aged patients (56.5%). A significant decrease of left ventricular (LV) ejection fraction (EF) at peak exercise was found in both patients groups (P <0.0001) while LVEF at rest was lower only in middle-aged patients (P = 0.004). An impaired LVEF at rest (2 = 8.1, P = 0.004). The exercise induced changes in LVEF (ΔEF) were significantly lower in both patients groups than in age-matched controls (P <0.0001). Impaired LVEF response to exercise (2 = 21.3, P <0.000): 21 young (65.6%) and 15 middle-aged patients (65.2%). The peak ejection rate (PER) was also significantly lower in young GHD patients than in controls (P <0.001). Exercise duration and capacity were significantly reduced in both groups of GHD patients. In the patient group, age was significantly correlated with SBP and DBP levels both at rest (r = 0.612, and r = 0.516, respectively, P <0.001) and at peak exercise (r = 0.4, P <0.005 and r = 0.34, P <0.01, respectively), with exercise duration (r = -0.383, P <0.005) and capacity (r = -0.355, P = 0.005). Disease duration was also correlated with IGF-I levels (r = -0.319, P <0.01), SBP levels at peak exercise (r = -0.352, P = 0.005), and LVEF at rest (r = -0.254, P <0.05). Finally, a significant correlation was found between IGF-I levels and DBP at peak exercise (r = 0.3, P <0.05) and between GH peak at ARG + GHRH test and LVEF at rest (r = 0.232, P <0.05). Exercise-induced changes in LVEF were significantly correlated with SBP levels at peak exercise (r = -0.401, P <0.005), PFR expressed as EDV/sec (r = -0.306, P <0.05) and SV/sec (r = -0.292, P <0.05). At multiple regression analysis in the patient group, age was the strongest predictor of SBP both at rest (t = 4.17, P <0.0001) and at peak exercise (t = 2.32, P = 0.025), and capacity (t = -2.84, P = 0.007). IGF-I levels were the strongest predictor of DBP at peak exercise (t = 2.2, P = 0.03). CONCLUSIONS: Diastolic filling abnormalities and impaired left ventricular ejection fraction response at peak exercise were found in the majority of patients with GHD acquired in adulthood, regardless of the patients age and age of disease onset. On this basis a careful cardiological assessment of GHD adult patients by radionuclide angiography can be helpful in diagnosing early stages of cardiac failure which could then be monitored during GH replacement therapy.

Original languageEnglish
Pages (from-to)447-455
Number of pages9
JournalClinical Endocrinology
Volume52
Issue number4
DOIs
Publication statusPublished - 2000

Fingerprint

Radionuclide Angiography
Age of Onset
Growth Hormone
Exercise
Blood Pressure
Insulin-Like Growth Factor I
Stroke Volume

ASJC Scopus subject areas

  • Endocrinology

Cite this

Does the age of onset of growth hormone deficiency affect cardiac performance? A radionuclide angiography study. / Colao, Annamaria; Cuocolo, Alberto; Di Somma, Carolina; Cerbone, Gaetana; Della Morte, Anna Maria; Pivonello, Rosario; Nicolai, Emanuele; Salvatore, Marco; Lombardi, Gaetano.

In: Clinical Endocrinology, Vol. 52, No. 4, 2000, p. 447-455.

Research output: Contribution to journalArticle

Colao, Annamaria ; Cuocolo, Alberto ; Di Somma, Carolina ; Cerbone, Gaetana ; Della Morte, Anna Maria ; Pivonello, Rosario ; Nicolai, Emanuele ; Salvatore, Marco ; Lombardi, Gaetano. / Does the age of onset of growth hormone deficiency affect cardiac performance? A radionuclide angiography study. In: Clinical Endocrinology. 2000 ; Vol. 52, No. 4. pp. 447-455.
@article{1845fcf8723a453f880a5f5e1774d54c,
title = "Does the age of onset of growth hormone deficiency affect cardiac performance? A radionuclide angiography study",
abstract = "BACKGROUND: GH and IGF-I seem to play a relevant role in cardiac development and performance. Longstanding GH deficiency (GHD) causes several abnormalities in cardiac structure and performance which ultimately determine an increased cardiovascular morbidity and mortality. OBJECTIVE: To investigate whether the age of onset of GHD plays a role in determining the negative effects on the heart. DESIGN: Open cross-sectional PATIENTS: 55 patients with adulthood-onset GHD and 36 healthy sex- and age-matched controls. Patients and controls were divided into 2 groups in line with age: 32 patients and 16 controls, were aged ≤ 35 years (young); while 23 patients and 20 controls were aged between 36 and 60 years (middle-aged). The estimated disease duration was similar in young (6.7 ± 0.5 years) and middle-aged patients (8.1 ± 1.2 years, P = 0.2). STUDY PROTOCOL: All subjects underwent ECG, blood pressure and heart rate measurement, plasma IGF-I level assay, and equilibrium radionuclide angiography. RESULTS: Plasma IGF-I levels were significantly lower in patients than in controls (P <0.0001). When considered as a whole, no difference in systolic (SBP) and diastolic blood pressure (DBP) at peak exercise was found between patients and controls. However, a significant decrease of SBP at rest was found in young patients as compared to age-matched controls (P = 0.009), while a significant increase of DBP at rest was found in middle-aged patients as compared to age-matched controls (P = 0.03). In addition, in young patients, both resting (P = 0.02) and exercise heart rate (P = 0.01) were significantly lower than in controls. Diastolic filling when measured as end-diastolic volume (EVD/sec), was significantly reduced in middle-aged patients (P = 0.04). An impaired peak filling rate (PFR) (2 = 5.3, P = 0.02): 17 young (53.1{\%}) and 13 middle-aged patients (56.5{\%}). A significant decrease of left ventricular (LV) ejection fraction (EF) at peak exercise was found in both patients groups (P <0.0001) while LVEF at rest was lower only in middle-aged patients (P = 0.004). An impaired LVEF at rest (2 = 8.1, P = 0.004). The exercise induced changes in LVEF (ΔEF) were significantly lower in both patients groups than in age-matched controls (P <0.0001). Impaired LVEF response to exercise (2 = 21.3, P <0.000): 21 young (65.6{\%}) and 15 middle-aged patients (65.2{\%}). The peak ejection rate (PER) was also significantly lower in young GHD patients than in controls (P <0.001). Exercise duration and capacity were significantly reduced in both groups of GHD patients. In the patient group, age was significantly correlated with SBP and DBP levels both at rest (r = 0.612, and r = 0.516, respectively, P <0.001) and at peak exercise (r = 0.4, P <0.005 and r = 0.34, P <0.01, respectively), with exercise duration (r = -0.383, P <0.005) and capacity (r = -0.355, P = 0.005). Disease duration was also correlated with IGF-I levels (r = -0.319, P <0.01), SBP levels at peak exercise (r = -0.352, P = 0.005), and LVEF at rest (r = -0.254, P <0.05). Finally, a significant correlation was found between IGF-I levels and DBP at peak exercise (r = 0.3, P <0.05) and between GH peak at ARG + GHRH test and LVEF at rest (r = 0.232, P <0.05). Exercise-induced changes in LVEF were significantly correlated with SBP levels at peak exercise (r = -0.401, P <0.005), PFR expressed as EDV/sec (r = -0.306, P <0.05) and SV/sec (r = -0.292, P <0.05). At multiple regression analysis in the patient group, age was the strongest predictor of SBP both at rest (t = 4.17, P <0.0001) and at peak exercise (t = 2.32, P = 0.025), and capacity (t = -2.84, P = 0.007). IGF-I levels were the strongest predictor of DBP at peak exercise (t = 2.2, P = 0.03). CONCLUSIONS: Diastolic filling abnormalities and impaired left ventricular ejection fraction response at peak exercise were found in the majority of patients with GHD acquired in adulthood, regardless of the patients age and age of disease onset. On this basis a careful cardiological assessment of GHD adult patients by radionuclide angiography can be helpful in diagnosing early stages of cardiac failure which could then be monitored during GH replacement therapy.",
author = "Annamaria Colao and Alberto Cuocolo and {Di Somma}, Carolina and Gaetana Cerbone and {Della Morte}, {Anna Maria} and Rosario Pivonello and Emanuele Nicolai and Marco Salvatore and Gaetano Lombardi",
year = "2000",
doi = "10.1046/j.1365-2265.2000.00972.x",
language = "English",
volume = "52",
pages = "447--455",
journal = "Clinical Endocrinology",
issn = "0300-0664",
publisher = "Wiley-Blackwell",
number = "4",

}

TY - JOUR

T1 - Does the age of onset of growth hormone deficiency affect cardiac performance? A radionuclide angiography study

AU - Colao, Annamaria

AU - Cuocolo, Alberto

AU - Di Somma, Carolina

AU - Cerbone, Gaetana

AU - Della Morte, Anna Maria

AU - Pivonello, Rosario

AU - Nicolai, Emanuele

AU - Salvatore, Marco

AU - Lombardi, Gaetano

PY - 2000

Y1 - 2000

N2 - BACKGROUND: GH and IGF-I seem to play a relevant role in cardiac development and performance. Longstanding GH deficiency (GHD) causes several abnormalities in cardiac structure and performance which ultimately determine an increased cardiovascular morbidity and mortality. OBJECTIVE: To investigate whether the age of onset of GHD plays a role in determining the negative effects on the heart. DESIGN: Open cross-sectional PATIENTS: 55 patients with adulthood-onset GHD and 36 healthy sex- and age-matched controls. Patients and controls were divided into 2 groups in line with age: 32 patients and 16 controls, were aged ≤ 35 years (young); while 23 patients and 20 controls were aged between 36 and 60 years (middle-aged). The estimated disease duration was similar in young (6.7 ± 0.5 years) and middle-aged patients (8.1 ± 1.2 years, P = 0.2). STUDY PROTOCOL: All subjects underwent ECG, blood pressure and heart rate measurement, plasma IGF-I level assay, and equilibrium radionuclide angiography. RESULTS: Plasma IGF-I levels were significantly lower in patients than in controls (P <0.0001). When considered as a whole, no difference in systolic (SBP) and diastolic blood pressure (DBP) at peak exercise was found between patients and controls. However, a significant decrease of SBP at rest was found in young patients as compared to age-matched controls (P = 0.009), while a significant increase of DBP at rest was found in middle-aged patients as compared to age-matched controls (P = 0.03). In addition, in young patients, both resting (P = 0.02) and exercise heart rate (P = 0.01) were significantly lower than in controls. Diastolic filling when measured as end-diastolic volume (EVD/sec), was significantly reduced in middle-aged patients (P = 0.04). An impaired peak filling rate (PFR) (2 = 5.3, P = 0.02): 17 young (53.1%) and 13 middle-aged patients (56.5%). A significant decrease of left ventricular (LV) ejection fraction (EF) at peak exercise was found in both patients groups (P <0.0001) while LVEF at rest was lower only in middle-aged patients (P = 0.004). An impaired LVEF at rest (2 = 8.1, P = 0.004). The exercise induced changes in LVEF (ΔEF) were significantly lower in both patients groups than in age-matched controls (P <0.0001). Impaired LVEF response to exercise (2 = 21.3, P <0.000): 21 young (65.6%) and 15 middle-aged patients (65.2%). The peak ejection rate (PER) was also significantly lower in young GHD patients than in controls (P <0.001). Exercise duration and capacity were significantly reduced in both groups of GHD patients. In the patient group, age was significantly correlated with SBP and DBP levels both at rest (r = 0.612, and r = 0.516, respectively, P <0.001) and at peak exercise (r = 0.4, P <0.005 and r = 0.34, P <0.01, respectively), with exercise duration (r = -0.383, P <0.005) and capacity (r = -0.355, P = 0.005). Disease duration was also correlated with IGF-I levels (r = -0.319, P <0.01), SBP levels at peak exercise (r = -0.352, P = 0.005), and LVEF at rest (r = -0.254, P <0.05). Finally, a significant correlation was found between IGF-I levels and DBP at peak exercise (r = 0.3, P <0.05) and between GH peak at ARG + GHRH test and LVEF at rest (r = 0.232, P <0.05). Exercise-induced changes in LVEF were significantly correlated with SBP levels at peak exercise (r = -0.401, P <0.005), PFR expressed as EDV/sec (r = -0.306, P <0.05) and SV/sec (r = -0.292, P <0.05). At multiple regression analysis in the patient group, age was the strongest predictor of SBP both at rest (t = 4.17, P <0.0001) and at peak exercise (t = 2.32, P = 0.025), and capacity (t = -2.84, P = 0.007). IGF-I levels were the strongest predictor of DBP at peak exercise (t = 2.2, P = 0.03). CONCLUSIONS: Diastolic filling abnormalities and impaired left ventricular ejection fraction response at peak exercise were found in the majority of patients with GHD acquired in adulthood, regardless of the patients age and age of disease onset. On this basis a careful cardiological assessment of GHD adult patients by radionuclide angiography can be helpful in diagnosing early stages of cardiac failure which could then be monitored during GH replacement therapy.

AB - BACKGROUND: GH and IGF-I seem to play a relevant role in cardiac development and performance. Longstanding GH deficiency (GHD) causes several abnormalities in cardiac structure and performance which ultimately determine an increased cardiovascular morbidity and mortality. OBJECTIVE: To investigate whether the age of onset of GHD plays a role in determining the negative effects on the heart. DESIGN: Open cross-sectional PATIENTS: 55 patients with adulthood-onset GHD and 36 healthy sex- and age-matched controls. Patients and controls were divided into 2 groups in line with age: 32 patients and 16 controls, were aged ≤ 35 years (young); while 23 patients and 20 controls were aged between 36 and 60 years (middle-aged). The estimated disease duration was similar in young (6.7 ± 0.5 years) and middle-aged patients (8.1 ± 1.2 years, P = 0.2). STUDY PROTOCOL: All subjects underwent ECG, blood pressure and heart rate measurement, plasma IGF-I level assay, and equilibrium radionuclide angiography. RESULTS: Plasma IGF-I levels were significantly lower in patients than in controls (P <0.0001). When considered as a whole, no difference in systolic (SBP) and diastolic blood pressure (DBP) at peak exercise was found between patients and controls. However, a significant decrease of SBP at rest was found in young patients as compared to age-matched controls (P = 0.009), while a significant increase of DBP at rest was found in middle-aged patients as compared to age-matched controls (P = 0.03). In addition, in young patients, both resting (P = 0.02) and exercise heart rate (P = 0.01) were significantly lower than in controls. Diastolic filling when measured as end-diastolic volume (EVD/sec), was significantly reduced in middle-aged patients (P = 0.04). An impaired peak filling rate (PFR) (2 = 5.3, P = 0.02): 17 young (53.1%) and 13 middle-aged patients (56.5%). A significant decrease of left ventricular (LV) ejection fraction (EF) at peak exercise was found in both patients groups (P <0.0001) while LVEF at rest was lower only in middle-aged patients (P = 0.004). An impaired LVEF at rest (2 = 8.1, P = 0.004). The exercise induced changes in LVEF (ΔEF) were significantly lower in both patients groups than in age-matched controls (P <0.0001). Impaired LVEF response to exercise (2 = 21.3, P <0.000): 21 young (65.6%) and 15 middle-aged patients (65.2%). The peak ejection rate (PER) was also significantly lower in young GHD patients than in controls (P <0.001). Exercise duration and capacity were significantly reduced in both groups of GHD patients. In the patient group, age was significantly correlated with SBP and DBP levels both at rest (r = 0.612, and r = 0.516, respectively, P <0.001) and at peak exercise (r = 0.4, P <0.005 and r = 0.34, P <0.01, respectively), with exercise duration (r = -0.383, P <0.005) and capacity (r = -0.355, P = 0.005). Disease duration was also correlated with IGF-I levels (r = -0.319, P <0.01), SBP levels at peak exercise (r = -0.352, P = 0.005), and LVEF at rest (r = -0.254, P <0.05). Finally, a significant correlation was found between IGF-I levels and DBP at peak exercise (r = 0.3, P <0.05) and between GH peak at ARG + GHRH test and LVEF at rest (r = 0.232, P <0.05). Exercise-induced changes in LVEF were significantly correlated with SBP levels at peak exercise (r = -0.401, P <0.005), PFR expressed as EDV/sec (r = -0.306, P <0.05) and SV/sec (r = -0.292, P <0.05). At multiple regression analysis in the patient group, age was the strongest predictor of SBP both at rest (t = 4.17, P <0.0001) and at peak exercise (t = 2.32, P = 0.025), and capacity (t = -2.84, P = 0.007). IGF-I levels were the strongest predictor of DBP at peak exercise (t = 2.2, P = 0.03). CONCLUSIONS: Diastolic filling abnormalities and impaired left ventricular ejection fraction response at peak exercise were found in the majority of patients with GHD acquired in adulthood, regardless of the patients age and age of disease onset. On this basis a careful cardiological assessment of GHD adult patients by radionuclide angiography can be helpful in diagnosing early stages of cardiac failure which could then be monitored during GH replacement therapy.

UR - http://www.scopus.com/inward/record.url?scp=0034059268&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0034059268&partnerID=8YFLogxK

U2 - 10.1046/j.1365-2265.2000.00972.x

DO - 10.1046/j.1365-2265.2000.00972.x

M3 - Article

C2 - 10762287

AN - SCOPUS:0034059268

VL - 52

SP - 447

EP - 455

JO - Clinical Endocrinology

JF - Clinical Endocrinology

SN - 0300-0664

IS - 4

ER -