Abstract
The pathogenesis and perpetuation of hepatocellular injury in chronic inflammatory liver disease is still unclear. Several pieces of circumstantial evidence point to the importance of antigen-specific immune responses. In chronic hepatitis B virus infection, the hepatitis B virus nucleoprotein appears to be a major target antigen for both helper and cytotoxic T lymphocytes. In autoimmune chronic active hepatitis, several autoantibodies have been identified that are associated with different disease subgroups and that may be helpful to distinguish this form of chronic active hepatitis from that caused by non-A, non-B agents. In primary biliary cirrhosis, antimitochondrial antibodies are almost invariably present and have now been characterized at the molecular level.
| Original language | English |
|---|---|
| Pages (from-to) | 489-497 |
| Number of pages | 9 |
| Journal | Archives of Pathology and Laboratory Medicine |
| Volume | 112 |
| Issue number | 5 |
| Publication status | Published - 1988 |
Fingerprint
ASJC Scopus subject areas
- Pathology and Forensic Medicine
- Medical Laboratory Technology
Cite this
Does the immune response play a role in the pathogenesis of chronic liver disease? / Mondelli, M. U.; Manns, M.; Ferrari, C.
In: Archives of Pathology and Laboratory Medicine, Vol. 112, No. 5, 1988, p. 489-497.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Does the immune response play a role in the pathogenesis of chronic liver disease?
AU - Mondelli, M. U.
AU - Manns, M.
AU - Ferrari, C.
PY - 1988
Y1 - 1988
N2 - The pathogenesis and perpetuation of hepatocellular injury in chronic inflammatory liver disease is still unclear. Several pieces of circumstantial evidence point to the importance of antigen-specific immune responses. In chronic hepatitis B virus infection, the hepatitis B virus nucleoprotein appears to be a major target antigen for both helper and cytotoxic T lymphocytes. In autoimmune chronic active hepatitis, several autoantibodies have been identified that are associated with different disease subgroups and that may be helpful to distinguish this form of chronic active hepatitis from that caused by non-A, non-B agents. In primary biliary cirrhosis, antimitochondrial antibodies are almost invariably present and have now been characterized at the molecular level.
AB - The pathogenesis and perpetuation of hepatocellular injury in chronic inflammatory liver disease is still unclear. Several pieces of circumstantial evidence point to the importance of antigen-specific immune responses. In chronic hepatitis B virus infection, the hepatitis B virus nucleoprotein appears to be a major target antigen for both helper and cytotoxic T lymphocytes. In autoimmune chronic active hepatitis, several autoantibodies have been identified that are associated with different disease subgroups and that may be helpful to distinguish this form of chronic active hepatitis from that caused by non-A, non-B agents. In primary biliary cirrhosis, antimitochondrial antibodies are almost invariably present and have now been characterized at the molecular level.
UR - http://www.scopus.com/inward/record.url?scp=0023921009&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0023921009&partnerID=8YFLogxK
M3 - Article
C2 - 3282484
AN - SCOPUS:0023921009
VL - 112
SP - 489
EP - 497
JO - Archives of Pathology and Laboratory Medicine
JF - Archives of Pathology and Laboratory Medicine
SN - 0003-9985
IS - 5
ER -