Does the multidimensional prognostic index (MPI), based on a comprehensive geriatric assessment (CGA), predict mortality in cancer patients? Results of a prospective observational trial

Valter Giantin, Elisabetta Valentini, Mario Iasevoli, Cristina Falci, Paola Siviero, Elisabetta De Luca, Stefania Maggi, Bruno Martella, Graziella Orrù, Gaetano Crepaldi, Silvio Monfardini, Oreste Terranova, Enzo Manzato

Research output: Contribution to journalArticlepeer-review

Abstract

Objective: Despite the lack of definitive data on the impact of Comprehensive Geriatric Assessment (CGA) in the geriatric oncology setting, the broad use of any form of CGA is strongly recommended before any treatment decision in elderly cancer patients (ECP); currently there is no consensus about the best format for this geriatric assessment. The aim of this study was to firstly test the Multidimensional Prognostic Index (MPI) in ECP with locally advanced or metastatic disease. Materials and Methods: Patients aged ≥ 70. years with inoperable or metastatic solid cancer consecutively admitted to our Program of Geriatric Oncology were assessed by a multidisciplinary team and received a basal CGA to calculate the MPI score. Results: A hundred and sixty patients entered the study. In the Cox's regression model, MPI, CIRS-SI, BSA, GDS, MMSE, chemotherapy and a diagnosis of primary lung cancer were associated with mortality at 6 and 12. months. The ROC curves confirmed the prognostic value of MPI, with the best discriminatory power for mortality at both 6 and 12. months. Conclusion: The present study is the first to indicate that the MPI retains its prognostic value even in elderly cancer patients with advanced stage of disease. The CIRS-SI and the GDS may potentiate the prognostic value of MPI.

Original languageEnglish
Pages (from-to)208-217
Number of pages10
JournalJournal of Geriatric Oncology
Volume4
Issue number3
DOIs
Publication statusPublished - Jul 2013

Keywords

  • Advanced cancer
  • Comprehensive Geriatric Assessment (CGA)
  • Elderly
  • Multidimensional Prognostic Index (MPI)
  • Prognosis

ASJC Scopus subject areas

  • Geriatrics and Gerontology
  • Oncology

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