TY - JOUR
T1 - Does the multidimensional prognostic index (MPI), based on a comprehensive geriatric assessment (CGA), predict mortality in cancer patients? Results of a prospective observational trial
AU - Giantin, Valter
AU - Valentini, Elisabetta
AU - Iasevoli, Mario
AU - Falci, Cristina
AU - Siviero, Paola
AU - De Luca, Elisabetta
AU - Maggi, Stefania
AU - Martella, Bruno
AU - Orrù, Graziella
AU - Crepaldi, Gaetano
AU - Monfardini, Silvio
AU - Terranova, Oreste
AU - Manzato, Enzo
PY - 2013/7
Y1 - 2013/7
N2 - Objective: Despite the lack of definitive data on the impact of Comprehensive Geriatric Assessment (CGA) in the geriatric oncology setting, the broad use of any form of CGA is strongly recommended before any treatment decision in elderly cancer patients (ECP); currently there is no consensus about the best format for this geriatric assessment. The aim of this study was to firstly test the Multidimensional Prognostic Index (MPI) in ECP with locally advanced or metastatic disease. Materials and Methods: Patients aged ≥ 70. years with inoperable or metastatic solid cancer consecutively admitted to our Program of Geriatric Oncology were assessed by a multidisciplinary team and received a basal CGA to calculate the MPI score. Results: A hundred and sixty patients entered the study. In the Cox's regression model, MPI, CIRS-SI, BSA, GDS, MMSE, chemotherapy and a diagnosis of primary lung cancer were associated with mortality at 6 and 12. months. The ROC curves confirmed the prognostic value of MPI, with the best discriminatory power for mortality at both 6 and 12. months. Conclusion: The present study is the first to indicate that the MPI retains its prognostic value even in elderly cancer patients with advanced stage of disease. The CIRS-SI and the GDS may potentiate the prognostic value of MPI.
AB - Objective: Despite the lack of definitive data on the impact of Comprehensive Geriatric Assessment (CGA) in the geriatric oncology setting, the broad use of any form of CGA is strongly recommended before any treatment decision in elderly cancer patients (ECP); currently there is no consensus about the best format for this geriatric assessment. The aim of this study was to firstly test the Multidimensional Prognostic Index (MPI) in ECP with locally advanced or metastatic disease. Materials and Methods: Patients aged ≥ 70. years with inoperable or metastatic solid cancer consecutively admitted to our Program of Geriatric Oncology were assessed by a multidisciplinary team and received a basal CGA to calculate the MPI score. Results: A hundred and sixty patients entered the study. In the Cox's regression model, MPI, CIRS-SI, BSA, GDS, MMSE, chemotherapy and a diagnosis of primary lung cancer were associated with mortality at 6 and 12. months. The ROC curves confirmed the prognostic value of MPI, with the best discriminatory power for mortality at both 6 and 12. months. Conclusion: The present study is the first to indicate that the MPI retains its prognostic value even in elderly cancer patients with advanced stage of disease. The CIRS-SI and the GDS may potentiate the prognostic value of MPI.
KW - Advanced cancer
KW - Comprehensive Geriatric Assessment (CGA)
KW - Elderly
KW - Multidimensional Prognostic Index (MPI)
KW - Prognosis
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U2 - 10.1016/j.jgo.2013.04.008
DO - 10.1016/j.jgo.2013.04.008
M3 - Article
C2 - 24070459
AN - SCOPUS:84878981754
VL - 4
SP - 208
EP - 217
JO - Journal of Geriatric Oncology
JF - Journal of Geriatric Oncology
SN - 1879-4068
IS - 3
ER -