Does the Type of Multisystem Atrophy, Parkinsonism, or Cerebellar Ataxia Impact on the Nature of Sleep Disorders?

Luigi Ferini-Strambi, Sara Marelli, Romina Combi

Research output: Contribution to journalReview articlepeer-review


Multiple system atrophy (MSA) is a neurodegenerative disease characterized by a combination of autonomic failure, parkinsonism, and/or cerebellar ataxia. The cause of MSA is unknown, but neuropathologically the disease is characterized by widespread α-synuclein-positive glial cytoplasmic inclusions and striatonigral and/or olivopontocerebellar neurodegeneration. Two motor phenotypes have been clinically identified: parkinsonian (MSA-P) and cerebellar (MSA-C). In order to elucidate if in addition to the motor abnormalities there are other significant differences between these two phenotypes, we performed a review of the studies on sleep disorders in the two MSA subtypes. Substantially, any significant difference in the sleep structure, as well as in the frequency and severity of the sleep disorders, has been found between MSA-P and MSA-C patients. Recent studies clearly showed similarities between the two MSA subtypes in terms of demographic distributions, natural history of the disease, and survivals. These findings suggest that although the dominant clinical presentations differ between MSA-C and MSA-P, a common pathophysiology may underlie both subtypes of MSA.

Original languageEnglish
Article number105
JournalCurrent Neurology and Neuroscience Reports
Issue number12
Publication statusPublished - Dec 1 2016


  • MSA-C
  • MSA-P
  • Multisystem atrophy
  • REM sleep behavior disorder
  • Sleep disorders
  • Stridor

ASJC Scopus subject areas

  • Neuroscience(all)
  • Clinical Neurology


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