Does V600E BRAF mutation predict vinorelbine efficacy? A proof-of-concept from a lung micropapillary adenocarcinoma metastatic to the breast

P. Carassai, G. Jocollé, G. Donati, S. Spinazzé, C. Baiocco, P. Baderna, A. Martinet, F. Lococo, F. Migliaccio, G. Rossi

Research output: Contribution to journalArticle

Abstract

BRAF mutations occur in about 3% of all lung adenocarcinomas and V600E missense mutation characterizes about half of BRAFmutated lung adenocarcinomas and is significantly associated with micropapillary pattern and shorter disease-free and overall survival rates. In this report, we report a challenging case of a patient with a metastatic micropapillary adenocarcinoma of the lung harbouring V600E BRAF mutation who experienced a surprising protracted clinical response to metronomic vinorelbine. The possible association between the V600E BRAF mutation pathway and the effective use of vinca alkaloid is discussed.

Original languageEnglish
Pages (from-to)426-428
Number of pages3
JournalPathologica
Volume109
Issue number4
Publication statusPublished - Dec 1 2017

Fingerprint

Breast
Mutation
Vinca Alkaloids
Missense Mutation
Disease-Free Survival
Survival Rate
Adenocarcinoma of lung
vinorelbine

Keywords

  • Adenocarcinoma
  • BRAF
  • Breast
  • Lung
  • Metastasis
  • Micropapillary
  • V600E
  • Vinorelbine

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

Carassai, P., Jocollé, G., Donati, G., Spinazzé, S., Baiocco, C., Baderna, P., ... Rossi, G. (2017). Does V600E BRAF mutation predict vinorelbine efficacy? A proof-of-concept from a lung micropapillary adenocarcinoma metastatic to the breast. Pathologica, 109(4), 426-428.

Does V600E BRAF mutation predict vinorelbine efficacy? A proof-of-concept from a lung micropapillary adenocarcinoma metastatic to the breast. / Carassai, P.; Jocollé, G.; Donati, G.; Spinazzé, S.; Baiocco, C.; Baderna, P.; Martinet, A.; Lococo, F.; Migliaccio, F.; Rossi, G.

In: Pathologica, Vol. 109, No. 4, 01.12.2017, p. 426-428.

Research output: Contribution to journalArticle

Carassai, P, Jocollé, G, Donati, G, Spinazzé, S, Baiocco, C, Baderna, P, Martinet, A, Lococo, F, Migliaccio, F & Rossi, G 2017, 'Does V600E BRAF mutation predict vinorelbine efficacy? A proof-of-concept from a lung micropapillary adenocarcinoma metastatic to the breast', Pathologica, vol. 109, no. 4, pp. 426-428.
Carassai, P. ; Jocollé, G. ; Donati, G. ; Spinazzé, S. ; Baiocco, C. ; Baderna, P. ; Martinet, A. ; Lococo, F. ; Migliaccio, F. ; Rossi, G. / Does V600E BRAF mutation predict vinorelbine efficacy? A proof-of-concept from a lung micropapillary adenocarcinoma metastatic to the breast. In: Pathologica. 2017 ; Vol. 109, No. 4. pp. 426-428.
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