Abstract
BRAF mutations occur in about 3% of all lung adenocarcinomas and V600E missense mutation characterizes about half of BRAFmutated lung adenocarcinomas and is significantly associated with micropapillary pattern and shorter disease-free and overall survival rates. In this report, we report a challenging case of a patient with a metastatic micropapillary adenocarcinoma of the lung harbouring V600E BRAF mutation who experienced a surprising protracted clinical response to metronomic vinorelbine. The possible association between the V600E BRAF mutation pathway and the effective use of vinca alkaloid is discussed.
| Original language | English |
|---|---|
| Pages (from-to) | 426-428 |
| Number of pages | 3 |
| Journal | Pathologica |
| Volume | 109 |
| Issue number | 4 |
| Publication status | Published - Dec 1 2017 |
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Keywords
- Adenocarcinoma
- BRAF
- Breast
- Lung
- Metastasis
- Micropapillary
- V600E
- Vinorelbine
ASJC Scopus subject areas
- Pathology and Forensic Medicine
Cite this
Does V600E BRAF mutation predict vinorelbine efficacy? A proof-of-concept from a lung micropapillary adenocarcinoma metastatic to the breast. / Carassai, P.; Jocollé, G.; Donati, G.; Spinazzé, S.; Baiocco, C.; Baderna, P.; Martinet, A.; Lococo, F.; Migliaccio, F.; Rossi, G.
In: Pathologica, Vol. 109, No. 4, 01.12.2017, p. 426-428.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Does V600E BRAF mutation predict vinorelbine efficacy? A proof-of-concept from a lung micropapillary adenocarcinoma metastatic to the breast
AU - Carassai, P.
AU - Jocollé, G.
AU - Donati, G.
AU - Spinazzé, S.
AU - Baiocco, C.
AU - Baderna, P.
AU - Martinet, A.
AU - Lococo, F.
AU - Migliaccio, F.
AU - Rossi, G.
PY - 2017/12/1
Y1 - 2017/12/1
N2 - BRAF mutations occur in about 3% of all lung adenocarcinomas and V600E missense mutation characterizes about half of BRAFmutated lung adenocarcinomas and is significantly associated with micropapillary pattern and shorter disease-free and overall survival rates. In this report, we report a challenging case of a patient with a metastatic micropapillary adenocarcinoma of the lung harbouring V600E BRAF mutation who experienced a surprising protracted clinical response to metronomic vinorelbine. The possible association between the V600E BRAF mutation pathway and the effective use of vinca alkaloid is discussed.
AB - BRAF mutations occur in about 3% of all lung adenocarcinomas and V600E missense mutation characterizes about half of BRAFmutated lung adenocarcinomas and is significantly associated with micropapillary pattern and shorter disease-free and overall survival rates. In this report, we report a challenging case of a patient with a metastatic micropapillary adenocarcinoma of the lung harbouring V600E BRAF mutation who experienced a surprising protracted clinical response to metronomic vinorelbine. The possible association between the V600E BRAF mutation pathway and the effective use of vinca alkaloid is discussed.
KW - Adenocarcinoma
KW - BRAF
KW - Breast
KW - Lung
KW - Metastasis
KW - Micropapillary
KW - V600E
KW - Vinorelbine
UR - http://www.scopus.com/inward/record.url?scp=85041498099&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85041498099&partnerID=8YFLogxK
M3 - Article
AN - SCOPUS:85041498099
VL - 109
SP - 426
EP - 428
JO - Pathologica
JF - Pathologica
SN - 0031-2983
IS - 4
ER -