Does Ventilatory Time Retain Its Validity in Predicting Neurodevelopmental Outcome at Two Years of Age in High-Risk Congenital Diaphragmatic Hernia Survivors?

Francesca Bevilacqua, Francesco Morini, Antonio Zaccara, Laura Valfrè, Lelia Rotondi Aufiero, Simonetta Gentile, Pietro Bagolan, Lucia Aite

Research output: Contribution to journalArticle

Abstract

Objective To evaluate if in high-risk non–extracorporeal membrane oxygenation (ECMO)-treated congenital diaphragmatic hernia (CDH) survivors, ventilatory time (VT) is correlated to and can be used as clinical marker of neurodevelopmental delay at 2 years of age. Study Design Cohort study was conducted between 2008 and 2012. Mental, motor, and language development were assessed by the Bayley Scales of Infant and Toddler Development III. The correlation between VT and neurodevelopmental outcome (NDO) was analyzed using Pearson's test. Receiver operating characteristic (ROC) analysis was performed to determine the accuracy and best cutoff value of VT to predict the risk of neurodevelopmental delay. Statistical significance was set at p <0.05. Results A total of 49 patients form the subject of this study. VT during first admission was inversely correlated with cognitive (r = –0.4116; p = 0.0033), motor (r = –0.4241; p = 0.0024), and language development (r = –0.3564; p = 0.0119). Using ROC curve analysis, VT was a significant predictor for neurodevelopmental delay in the cognitive (area under the curve [AUC]: 0.864, sensitivity: 100; specificity: 66.67; p <0.0001) and motor (AUC: 0.902; sensitivity: 100; specificity: 73.17; p <0.0001) scales, but not in the language scale. The best cutoff value for both scales was 9 days. Conclusion Within a population of high-risk non-ECMO-treated CDH survivors, VT appears to retain its validity as a clinical marker of adverse NDO in cognitive and motor domains.

Original languageEnglish
JournalAmerican Journal of Perinatology
DOIs
Publication statusAccepted/In press - Jun 17 2016

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Survivors
Language Development
ROC Curve
Area Under Curve
Biomarkers
Sensitivity and Specificity
Motor Cortex
Child Development
Congenital Diaphragmatic Hernias
Cohort Studies
Language
Membranes
Population

Keywords

  • CDH
  • neurodevelopmental outcome
  • ventilatory time

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Obstetrics and Gynaecology

Cite this

@article{4c11a6c2970547cb97d7e2c6e8aa18fd,
title = "Does Ventilatory Time Retain Its Validity in Predicting Neurodevelopmental Outcome at Two Years of Age in High-Risk Congenital Diaphragmatic Hernia Survivors?",
abstract = "Objective To evaluate if in high-risk non–extracorporeal membrane oxygenation (ECMO)-treated congenital diaphragmatic hernia (CDH) survivors, ventilatory time (VT) is correlated to and can be used as clinical marker of neurodevelopmental delay at 2 years of age. Study Design Cohort study was conducted between 2008 and 2012. Mental, motor, and language development were assessed by the Bayley Scales of Infant and Toddler Development III. The correlation between VT and neurodevelopmental outcome (NDO) was analyzed using Pearson's test. Receiver operating characteristic (ROC) analysis was performed to determine the accuracy and best cutoff value of VT to predict the risk of neurodevelopmental delay. Statistical significance was set at p <0.05. Results A total of 49 patients form the subject of this study. VT during first admission was inversely correlated with cognitive (r = –0.4116; p = 0.0033), motor (r = –0.4241; p = 0.0024), and language development (r = –0.3564; p = 0.0119). Using ROC curve analysis, VT was a significant predictor for neurodevelopmental delay in the cognitive (area under the curve [AUC]: 0.864, sensitivity: 100; specificity: 66.67; p <0.0001) and motor (AUC: 0.902; sensitivity: 100; specificity: 73.17; p <0.0001) scales, but not in the language scale. The best cutoff value for both scales was 9 days. Conclusion Within a population of high-risk non-ECMO-treated CDH survivors, VT appears to retain its validity as a clinical marker of adverse NDO in cognitive and motor domains.",
keywords = "CDH, neurodevelopmental outcome, ventilatory time",
author = "Francesca Bevilacqua and Francesco Morini and Antonio Zaccara and Laura Valfr{\`e} and Aufiero, {Lelia Rotondi} and Simonetta Gentile and Pietro Bagolan and Lucia Aite",
year = "2016",
month = "6",
day = "17",
doi = "10.1055/s-0036-1586120",
language = "English",
journal = "American Journal of Perinatology",
issn = "0735-1631",
publisher = "Thieme Medical Publishers, Inc.",

}

TY - JOUR

T1 - Does Ventilatory Time Retain Its Validity in Predicting Neurodevelopmental Outcome at Two Years of Age in High-Risk Congenital Diaphragmatic Hernia Survivors?

AU - Bevilacqua, Francesca

AU - Morini, Francesco

AU - Zaccara, Antonio

AU - Valfrè, Laura

AU - Aufiero, Lelia Rotondi

AU - Gentile, Simonetta

AU - Bagolan, Pietro

AU - Aite, Lucia

PY - 2016/6/17

Y1 - 2016/6/17

N2 - Objective To evaluate if in high-risk non–extracorporeal membrane oxygenation (ECMO)-treated congenital diaphragmatic hernia (CDH) survivors, ventilatory time (VT) is correlated to and can be used as clinical marker of neurodevelopmental delay at 2 years of age. Study Design Cohort study was conducted between 2008 and 2012. Mental, motor, and language development were assessed by the Bayley Scales of Infant and Toddler Development III. The correlation between VT and neurodevelopmental outcome (NDO) was analyzed using Pearson's test. Receiver operating characteristic (ROC) analysis was performed to determine the accuracy and best cutoff value of VT to predict the risk of neurodevelopmental delay. Statistical significance was set at p <0.05. Results A total of 49 patients form the subject of this study. VT during first admission was inversely correlated with cognitive (r = –0.4116; p = 0.0033), motor (r = –0.4241; p = 0.0024), and language development (r = –0.3564; p = 0.0119). Using ROC curve analysis, VT was a significant predictor for neurodevelopmental delay in the cognitive (area under the curve [AUC]: 0.864, sensitivity: 100; specificity: 66.67; p <0.0001) and motor (AUC: 0.902; sensitivity: 100; specificity: 73.17; p <0.0001) scales, but not in the language scale. The best cutoff value for both scales was 9 days. Conclusion Within a population of high-risk non-ECMO-treated CDH survivors, VT appears to retain its validity as a clinical marker of adverse NDO in cognitive and motor domains.

AB - Objective To evaluate if in high-risk non–extracorporeal membrane oxygenation (ECMO)-treated congenital diaphragmatic hernia (CDH) survivors, ventilatory time (VT) is correlated to and can be used as clinical marker of neurodevelopmental delay at 2 years of age. Study Design Cohort study was conducted between 2008 and 2012. Mental, motor, and language development were assessed by the Bayley Scales of Infant and Toddler Development III. The correlation between VT and neurodevelopmental outcome (NDO) was analyzed using Pearson's test. Receiver operating characteristic (ROC) analysis was performed to determine the accuracy and best cutoff value of VT to predict the risk of neurodevelopmental delay. Statistical significance was set at p <0.05. Results A total of 49 patients form the subject of this study. VT during first admission was inversely correlated with cognitive (r = –0.4116; p = 0.0033), motor (r = –0.4241; p = 0.0024), and language development (r = –0.3564; p = 0.0119). Using ROC curve analysis, VT was a significant predictor for neurodevelopmental delay in the cognitive (area under the curve [AUC]: 0.864, sensitivity: 100; specificity: 66.67; p <0.0001) and motor (AUC: 0.902; sensitivity: 100; specificity: 73.17; p <0.0001) scales, but not in the language scale. The best cutoff value for both scales was 9 days. Conclusion Within a population of high-risk non-ECMO-treated CDH survivors, VT appears to retain its validity as a clinical marker of adverse NDO in cognitive and motor domains.

KW - CDH

KW - neurodevelopmental outcome

KW - ventilatory time

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U2 - 10.1055/s-0036-1586120

DO - 10.1055/s-0036-1586120

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AN - SCOPUS:84979653130

JO - American Journal of Perinatology

JF - American Journal of Perinatology

SN - 0735-1631

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