Dog as model for down-expression of E-cadherin and β-catenin in tubular epithelial cells in renal fibrosis

Luca Aresu, Maria Pia Rastaldi, Paola Pregel, Federico Valenza, Enrico Radaelli, Eugenio Scanziani, Massimo Castagnaro

Research output: Contribution to journalArticle

Abstract

Mechanism of renal fibrosis leading to end stage kidney remains still a challenge of interest in humans. The pathogenesis of chronic kidney disease is characterized by progressive loss of kidney function and fibrosis. The mechanism of epithelial-mesenchymal transition (EMT) has been predominantly studied in in vitro studies, and we previously demonstrated the EMT of tubular epithelial cells in dogs. In this study, we examined and quantified the modifications of cadherin-catenin complex by immunohistochemistry of E-cadherin and β-catenin and the mesenchymal marker vimentin in 25 dogs with three different spontaneous inflammatory renal diseases. Results showed a significant down-expression of levels of E-cadherin and β-catenin directly correlated with the tubular-interstitial damage (TID). In TID grades 2 and 3, E-cadherin expression was significantly reduced (p

Original languageEnglish
Pages (from-to)617-625
Number of pages9
JournalVirchows Archiv
Volume453
Issue number6
DOIs
Publication statusPublished - Dec 2008

Keywords

  • Adhesion molecule
  • Canine
  • Fibrosis

ASJC Scopus subject areas

  • Cell Biology
  • Molecular Biology
  • Pathology and Forensic Medicine

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