Dolutegravir in antiretroviral-experienced patients with raltegravir- and/or elvitegravir-resistant HIV-1: 24-week results of the phase III VIKING-3 study

Antonella Castagna; Franco Maggiolo; Giovanni Penco; David Wright; Anthony Mills; Robert Grossberg; Jean Michel Molina; Julie Chas; Jacques Durant; Santiago Moreno; Manuela Doroana; Mounir Ait-Khaled; Jenny Huang; Sherene Min; Ivy Song; Cindy Vavro; Garrett Nichols; Jane M. Yeo

doi:10.1093/infdis/jiu051

Dolutegravir in antiretroviral-experienced patients with raltegravir- and/or elvitegravir-resistant HIV-1: 24-week results of the phase III VIKING-3 study

Antonella Castagna, Franco Maggiolo, Giovanni Penco, David Wright, Anthony Mills, Robert Grossberg, Jean Michel Molina, Julie Chas, Jacques Durant, Santiago Moreno, Manuela Doroana, Mounir Ait-Khaled, Jenny Huang, Sherene Min, Ivy Song, Cindy Vavro, Garrett Nichols, Jane M. Yeo

IRCCS Ospedale San Raffaele

Research output: Contribution to journal › Article › peer-review

Abstract

Background. The pilot phase IIb VIKING study suggested that dolutegravir (DTG), a human immunodeficiency virus (HIV) integrase inhibitor (INI), would be efficacious in INI-resistant patients at the 50 mg twice daily (BID) dose. Methods. VIKING-3 is a single-arm, open-label phase III study in which therapy-experienced adults with INIresistant virus received DTG 50 mg BID while continuing their failing regimen (without raltegravir or elvitegravir) through day 7, after which the regimen was optimized with ≥1 fully active drug and DTG continued. The primary efficacy endpoints were the mean change from baseline in plasma HIV-1 RNA at day 8 and the proportion of subjects with HIV-1 RNA

Original language	English
Pages (from-to)	354-362
Number of pages	9
Journal	Journal of Infectious Diseases
Volume	210
Issue number	3
DOIs	https://doi.org/10.1093/infdis/jiu051
Publication status	Published - Aug 1 2014

Keywords

Dolutegravir
DTG
Elvitegravir resistance
Integrase inhibitor
Raltegravir resistance

ASJC Scopus subject areas

Infectious Diseases
Immunology and Allergy

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10.1093/infdis/jiu051

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Castagna, A., Maggiolo, F., Penco, G., Wright, D., Mills, A., Grossberg, R., Molina, J. M., Chas, J., Durant, J., Moreno, S., Doroana, M., Ait-Khaled, M., Huang, J., Min, S., Song, I., Vavro, C., Nichols, G., & Yeo, J. M. (2014). Dolutegravir in antiretroviral-experienced patients with raltegravir- and/or elvitegravir-resistant HIV-1: 24-week results of the phase III VIKING-3 study. Journal of Infectious Diseases, 210(3), 354-362. https://doi.org/10.1093/infdis/jiu051

Dolutegravir in antiretroviral-experienced patients with raltegravir- and/or elvitegravir-resistant HIV-1 : 24-week results of the phase III VIKING-3 study. / Castagna, Antonella; Maggiolo, Franco; Penco, Giovanni; Wright, David; Mills, Anthony; Grossberg, Robert; Molina, Jean Michel; Chas, Julie; Durant, Jacques; Moreno, Santiago; Doroana, Manuela; Ait-Khaled, Mounir; Huang, Jenny; Min, Sherene; Song, Ivy; Vavro, Cindy; Nichols, Garrett; Yeo, Jane M.

In: Journal of Infectious Diseases, Vol. 210, No. 3, 01.08.2014, p. 354-362.

Research output: Contribution to journal › Article › peer-review

Castagna, A, Maggiolo, F, Penco, G, Wright, D, Mills, A, Grossberg, R, Molina, JM, Chas, J, Durant, J, Moreno, S, Doroana, M, Ait-Khaled, M, Huang, J, Min, S, Song, I, Vavro, C, Nichols, G & Yeo, JM 2014, 'Dolutegravir in antiretroviral-experienced patients with raltegravir- and/or elvitegravir-resistant HIV-1: 24-week results of the phase III VIKING-3 study', Journal of Infectious Diseases, vol. 210, no. 3, pp. 354-362. https://doi.org/10.1093/infdis/jiu051

Castagna, Antonella ; Maggiolo, Franco ; Penco, Giovanni ; Wright, David ; Mills, Anthony ; Grossberg, Robert ; Molina, Jean Michel ; Chas, Julie ; Durant, Jacques ; Moreno, Santiago ; Doroana, Manuela ; Ait-Khaled, Mounir ; Huang, Jenny ; Min, Sherene ; Song, Ivy ; Vavro, Cindy ; Nichols, Garrett ; Yeo, Jane M. / Dolutegravir in antiretroviral-experienced patients with raltegravir- and/or elvitegravir-resistant HIV-1 : 24-week results of the phase III VIKING-3 study. In: Journal of Infectious Diseases. 2014 ; Vol. 210, No. 3. pp. 354-362.

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abstract = "Background. The pilot phase IIb VIKING study suggested that dolutegravir (DTG), a human immunodeficiency virus (HIV) integrase inhibitor (INI), would be efficacious in INI-resistant patients at the 50 mg twice daily (BID) dose. Methods. VIKING-3 is a single-arm, open-label phase III study in which therapy-experienced adults with INIresistant virus received DTG 50 mg BID while continuing their failing regimen (without raltegravir or elvitegravir) through day 7, after which the regimen was optimized with ≥1 fully active drug and DTG continued. The primary efficacy endpoints were the mean change from baseline in plasma HIV-1 RNA at day 8 and the proportion of subjects with HIV-1 RNA ",

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Dolutegravir in antiretroviral-experienced patients with raltegravir- and/or elvitegravir-resistant HIV-1: 24-week results of the phase III VIKING-3 study

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