Donepezil decreases annual rate of hippocampal atrophy in suspected prodromal Alzheimer's disease

Bruno Dubois; Marie Chupin; Harald Hampel; Simone Lista; Enrica Cavedo; Bernard Croisile; Guy Louis Tisserand; Jacques Touchon; Alain Bonafe; Pierre Jean Ousset; Amir Ait Ameur; Olivier Rouaud; Fréderic Ricolfi; Alain Vighetto; Florence Pasquier; Christine Delmaire; Mathieu Ceccaldi; Nadine Girard; Carole Dufouil; Stéphane Lehericy; Isabelle Tonelli; Françoise Duveau; Olivier Colliot; Line Garnero; Marie Sarazin; Didier Dormont; H. Deramond; F. Etcharry Bouyx; A. Pasco Papon; O. Moreaud; A. Krainik; S. Bombois; P. Couratier; A. Maubon; B. Croisile; G. Louis-Tisserand; B. Michel; M. P. Peretti; A. Benetos; G. Barroche; S. Bracard; M. Vercelletto; E. Calvier Auffray; P. Robert; S. Chanalet; J. Hugon; M. P. Pancrazi; D. Reizine; R. Gil; P. Vandermarcq; J. L. Novella; L. Pierot; S. Belliard; M. Carsin; O. Martinaud; E. Gerardin; B. Laurent; F. G. Barral; F. Sellal; M. Puel; H. Dumas; K. Mondon; J. P. Cottier

doi:10.1016/j.jalz.2014.10.003

Donepezil decreases annual rate of hippocampal atrophy in suspected prodromal Alzheimer's disease

Bruno Dubois, Marie Chupin, Harald Hampel, Simone Lista, Enrica Cavedo, Bernard Croisile, Guy Louis Tisserand, Jacques Touchon, Alain Bonafe, Pierre Jean Ousset, Amir Ait Ameur, Olivier Rouaud, Fréderic Ricolfi, Alain Vighetto, Florence Pasquier, Christine Delmaire, Mathieu Ceccaldi, Nadine Girard, Carole Dufouil, Stéphane LehericyIsabelle Tonelli, Françoise Duveau, Olivier Colliot, Line Garnero, Marie Sarazin, Didier Dormont, H. Deramond, F. Etcharry Bouyx, A. Pasco Papon, O. Moreaud, A. Krainik, S. Bombois, P. Couratier, A. Maubon, B. Croisile, G. Louis-Tisserand, B. Michel, M. P. Peretti, A. Benetos, G. Barroche, S. Bracard, M. Vercelletto, E. Calvier Auffray, P. Robert, S. Chanalet, J. Hugon, M. P. Pancrazi, D. Reizine, R. Gil, P. Vandermarcq, J. L. Novella, L. Pierot, S. Belliard, M. Carsin, O. Martinaud, E. Gerardin, B. Laurent, F. G. Barral, F. Sellal, M. Puel, H. Dumas, K. Mondon, J. P. Cottier

Centro San Giovanni di Dio - Fatebenefratelli

Research output: Contribution to journal › Article › peer-review

Abstract

Introduction The purpose of this study was to study the effect of donepezil on the rate of hippocampal atrophy in prodromal Alzheimer's disease (AD). Methods A double-blind, randomized, placebo-controlled parallel group design using donepezil (10 mg/day) in subjects with suspected prodromal AD. Subjects underwent two brain magnetic resonance imaging scans (baseline and final visit). The primary efficacy outcome was the annualized percentage change (APC) of total hippocampal volume (left + right) measured by an automated segmentation method. Results Two-hundred and sixteen only subjects were randomized across 28 French expert clinical sites. In the per protocol population (placebo = 92 and donepezil = 82), the donepezil group exhibited a significant reduced rate of hippocampal atrophy (APC = -1.89%) compared with the placebo group (APC = -3.47%), P <.001. There was no significant difference in neuropsychological performance between treatment groups. Discussion A 45% reduction of rate of hippocampal atrophy was observed in prodromal AD following 1 year of treatment with donepezil compared with placebo.

Original language	English
Article number	1924
Pages (from-to)	1041-1049
Number of pages	9
Journal	Alzheimer's and Dementia
Volume	11
Issue number	9
DOIs	https://doi.org/10.1016/j.jalz.2014.10.003
Publication status	Published - Sep 1 2015

Keywords

Alzheimer's disease
Amnestic MCI
Biomarker
Donepezil
Hippocampus
Mild cognitive impairment
MRI
Prodromal Alzheimer's disease
Randomized controlled trial
Rate of atrophy
Therapy
Volumetric imaging
Whole brain analysis

ASJC Scopus subject areas

Clinical Neurology
Developmental Neuroscience
Cellular and Molecular Neuroscience
Psychiatry and Mental health
Geriatrics and Gerontology
Epidemiology
Health Policy

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Dubois, B., Chupin, M., Hampel, H., Lista, S., Cavedo, E., Croisile, B., Louis Tisserand, G., Touchon, J., Bonafe, A., Ousset, P. J., Ait Ameur, A., Rouaud, O., Ricolfi, F., Vighetto, A., Pasquier, F., Delmaire, C., Ceccaldi, M., Girard, N., Dufouil, C., ... Cottier, J. P. (2015). Donepezil decreases annual rate of hippocampal atrophy in suspected prodromal Alzheimer's disease. Alzheimer's and Dementia, 11(9), 1041-1049. [1924]. https://doi.org/10.1016/j.jalz.2014.10.003

Donepezil decreases annual rate of hippocampal atrophy in suspected prodromal Alzheimer's disease. / Dubois, Bruno; Chupin, Marie; Hampel, Harald; Lista, Simone; Cavedo, Enrica; Croisile, Bernard; Louis Tisserand, Guy; Touchon, Jacques; Bonafe, Alain; Ousset, Pierre Jean; Ait Ameur, Amir; Rouaud, Olivier; Ricolfi, Fréderic; Vighetto, Alain; Pasquier, Florence; Delmaire, Christine; Ceccaldi, Mathieu; Girard, Nadine; Dufouil, Carole; Lehericy, Stéphane; Tonelli, Isabelle; Duveau, Françoise; Colliot, Olivier; Garnero, Line; Sarazin, Marie; Dormont, Didier; Deramond, H.; Etcharry Bouyx, F.; Pasco Papon, A.; Moreaud, O.; Krainik, A.; Bombois, S.; Couratier, P.; Maubon, A.; Croisile, B.; Louis-Tisserand, G.; Michel, B.; Peretti, M. P.; Benetos, A.; Barroche, G.; Bracard, S.; Vercelletto, M.; Calvier Auffray, E.; Robert, P.; Chanalet, S.; Hugon, J.; Pancrazi, M. P.; Reizine, D.; Gil, R.; Vandermarcq, P.; Novella, J. L.; Pierot, L.; Belliard, S.; Carsin, M.; Martinaud, O.; Gerardin, E.; Laurent, B.; Barral, F. G.; Sellal, F.; Puel, M.; Dumas, H.; Mondon, K.; Cottier, J. P.

In: Alzheimer's and Dementia, Vol. 11, No. 9, 1924, 01.09.2015, p. 1041-1049.

Research output: Contribution to journal › Article › peer-review

Dubois, B, Chupin, M, Hampel, H, Lista, S, Cavedo, E, Croisile, B, Louis Tisserand, G, Touchon, J, Bonafe, A, Ousset, PJ, Ait Ameur, A, Rouaud, O, Ricolfi, F, Vighetto, A, Pasquier, F, Delmaire, C, Ceccaldi, M, Girard, N, Dufouil, C, Lehericy, S, Tonelli, I, Duveau, F, Colliot, O, Garnero, L, Sarazin, M, Dormont, D, Deramond, H, Etcharry Bouyx, F, Pasco Papon, A, Moreaud, O, Krainik, A, Bombois, S, Couratier, P, Maubon, A, Croisile, B, Louis-Tisserand, G, Michel, B, Peretti, MP, Benetos, A, Barroche, G, Bracard, S, Vercelletto, M, Calvier Auffray, E, Robert, P, Chanalet, S, Hugon, J, Pancrazi, MP, Reizine, D, Gil, R, Vandermarcq, P, Novella, JL, Pierot, L, Belliard, S, Carsin, M, Martinaud, O, Gerardin, E, Laurent, B, Barral, FG, Sellal, F, Puel, M, Dumas, H, Mondon, K & Cottier, JP 2015, 'Donepezil decreases annual rate of hippocampal atrophy in suspected prodromal Alzheimer's disease', Alzheimer's and Dementia, vol. 11, no. 9, 1924, pp. 1041-1049. https://doi.org/10.1016/j.jalz.2014.10.003

Dubois, Bruno ; Chupin, Marie ; Hampel, Harald ; Lista, Simone ; Cavedo, Enrica ; Croisile, Bernard ; Louis Tisserand, Guy ; Touchon, Jacques ; Bonafe, Alain ; Ousset, Pierre Jean ; Ait Ameur, Amir ; Rouaud, Olivier ; Ricolfi, Fréderic ; Vighetto, Alain ; Pasquier, Florence ; Delmaire, Christine ; Ceccaldi, Mathieu ; Girard, Nadine ; Dufouil, Carole ; Lehericy, Stéphane ; Tonelli, Isabelle ; Duveau, Françoise ; Colliot, Olivier ; Garnero, Line ; Sarazin, Marie ; Dormont, Didier ; Deramond, H. ; Etcharry Bouyx, F. ; Pasco Papon, A. ; Moreaud, O. ; Krainik, A. ; Bombois, S. ; Couratier, P. ; Maubon, A. ; Croisile, B. ; Louis-Tisserand, G. ; Michel, B. ; Peretti, M. P. ; Benetos, A. ; Barroche, G. ; Bracard, S. ; Vercelletto, M. ; Calvier Auffray, E. ; Robert, P. ; Chanalet, S. ; Hugon, J. ; Pancrazi, M. P. ; Reizine, D. ; Gil, R. ; Vandermarcq, P. ; Novella, J. L. ; Pierot, L. ; Belliard, S. ; Carsin, M. ; Martinaud, O. ; Gerardin, E. ; Laurent, B. ; Barral, F. G. ; Sellal, F. ; Puel, M. ; Dumas, H. ; Mondon, K. ; Cottier, J. P. / Donepezil decreases annual rate of hippocampal atrophy in suspected prodromal Alzheimer's disease. In: Alzheimer's and Dementia. 2015 ; Vol. 11, No. 9. pp. 1041-1049.

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abstract = "Introduction The purpose of this study was to study the effect of donepezil on the rate of hippocampal atrophy in prodromal Alzheimer's disease (AD). Methods A double-blind, randomized, placebo-controlled parallel group design using donepezil (10 mg/day) in subjects with suspected prodromal AD. Subjects underwent two brain magnetic resonance imaging scans (baseline and final visit). The primary efficacy outcome was the annualized percentage change (APC) of total hippocampal volume (left + right) measured by an automated segmentation method. Results Two-hundred and sixteen only subjects were randomized across 28 French expert clinical sites. In the per protocol population (placebo = 92 and donepezil = 82), the donepezil group exhibited a significant reduced rate of hippocampal atrophy (APC = -1.89%) compared with the placebo group (APC = -3.47%), P <.001. There was no significant difference in neuropsychological performance between treatment groups. Discussion A 45% reduction of rate of hippocampal atrophy was observed in prodromal AD following 1 year of treatment with donepezil compared with placebo.",

keywords = "Alzheimer's disease, Amnestic MCI, Biomarker, Donepezil, Hippocampus, Mild cognitive impairment, MRI, Prodromal Alzheimer's disease, Randomized controlled trial, Rate of atrophy, Therapy, Volumetric imaging, Whole brain analysis",

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T1 - Donepezil decreases annual rate of hippocampal atrophy in suspected prodromal Alzheimer's disease

AU - Dubois, Bruno

AU - Chupin, Marie

AU - Hampel, Harald

AU - Lista, Simone

AU - Cavedo, Enrica

AU - Croisile, Bernard

AU - Louis Tisserand, Guy

AU - Touchon, Jacques

AU - Bonafe, Alain

AU - Ousset, Pierre Jean

AU - Ait Ameur, Amir

AU - Rouaud, Olivier

AU - Ricolfi, Fréderic

AU - Vighetto, Alain

AU - Pasquier, Florence

AU - Delmaire, Christine

AU - Ceccaldi, Mathieu

AU - Girard, Nadine

AU - Dufouil, Carole

AU - Lehericy, Stéphane

AU - Tonelli, Isabelle

AU - Duveau, Françoise

AU - Colliot, Olivier

AU - Garnero, Line

AU - Sarazin, Marie

AU - Dormont, Didier

AU - Deramond, H.

AU - Etcharry Bouyx, F.

AU - Pasco Papon, A.

AU - Moreaud, O.

AU - Krainik, A.

AU - Bombois, S.

AU - Couratier, P.

AU - Maubon, A.

AU - Croisile, B.

AU - Louis-Tisserand, G.

AU - Michel, B.

AU - Peretti, M. P.

AU - Benetos, A.

AU - Barroche, G.

AU - Bracard, S.

AU - Vercelletto, M.

AU - Calvier Auffray, E.

AU - Robert, P.

AU - Chanalet, S.

AU - Hugon, J.

AU - Pancrazi, M. P.

AU - Reizine, D.

AU - Gil, R.

AU - Vandermarcq, P.

AU - Novella, J. L.

AU - Pierot, L.

AU - Belliard, S.

AU - Carsin, M.

AU - Martinaud, O.

AU - Gerardin, E.

AU - Laurent, B.

AU - Barral, F. G.

AU - Sellal, F.

AU - Puel, M.

AU - Dumas, H.

AU - Mondon, K.

AU - Cottier, J. P.

PY - 2015/9/1

Y1 - 2015/9/1

N2 - Introduction The purpose of this study was to study the effect of donepezil on the rate of hippocampal atrophy in prodromal Alzheimer's disease (AD). Methods A double-blind, randomized, placebo-controlled parallel group design using donepezil (10 mg/day) in subjects with suspected prodromal AD. Subjects underwent two brain magnetic resonance imaging scans (baseline and final visit). The primary efficacy outcome was the annualized percentage change (APC) of total hippocampal volume (left + right) measured by an automated segmentation method. Results Two-hundred and sixteen only subjects were randomized across 28 French expert clinical sites. In the per protocol population (placebo = 92 and donepezil = 82), the donepezil group exhibited a significant reduced rate of hippocampal atrophy (APC = -1.89%) compared with the placebo group (APC = -3.47%), P <.001. There was no significant difference in neuropsychological performance between treatment groups. Discussion A 45% reduction of rate of hippocampal atrophy was observed in prodromal AD following 1 year of treatment with donepezil compared with placebo.

AB - Introduction The purpose of this study was to study the effect of donepezil on the rate of hippocampal atrophy in prodromal Alzheimer's disease (AD). Methods A double-blind, randomized, placebo-controlled parallel group design using donepezil (10 mg/day) in subjects with suspected prodromal AD. Subjects underwent two brain magnetic resonance imaging scans (baseline and final visit). The primary efficacy outcome was the annualized percentage change (APC) of total hippocampal volume (left + right) measured by an automated segmentation method. Results Two-hundred and sixteen only subjects were randomized across 28 French expert clinical sites. In the per protocol population (placebo = 92 and donepezil = 82), the donepezil group exhibited a significant reduced rate of hippocampal atrophy (APC = -1.89%) compared with the placebo group (APC = -3.47%), P <.001. There was no significant difference in neuropsychological performance between treatment groups. Discussion A 45% reduction of rate of hippocampal atrophy was observed in prodromal AD following 1 year of treatment with donepezil compared with placebo.

KW - Alzheimer's disease

KW - Amnestic MCI

KW - Biomarker

KW - Donepezil

KW - Hippocampus

KW - Mild cognitive impairment

KW - MRI

KW - Prodromal Alzheimer's disease

KW - Randomized controlled trial

KW - Rate of atrophy

KW - Therapy

KW - Volumetric imaging

KW - Whole brain analysis

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VL - 11

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JO - Alzheimer's and Dementia

JF - Alzheimer's and Dementia

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