Donor-host cross circulation before skin homograft in the rat

A. T. Di Marco, C. Franceschi, A. Di Marco, G. Prodi

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An investigation was made on the effects of donor-host cross circulation on skin homograft rejection in the rat, a test being made of various histocompatibility barriers: F1 (F/344 X Lew) → F/344, F/344 ⇄ Lew, F/344 ⇄ Bf. We obtained the most significant prolongation of graft survival by grafting hybrid F1 (F/344 X Lew) skin on F/344 cross circulated with Lew 2 days before. Positive results were obtained with the combination Lew ⇋ F/344 if the F/344 or Lew skin grafts were carried out 2 days after cross circulation. No effect was observed if the grafts were performed 22 days later, preceded by the i.v. injection of 5 X 107 donor spleen cells. The administration alone of 108 spleen cells resulted in a fair degree of activity in the F/344 → Lew combination and not vice versa. The results obtained with the strong histocompatibility barrier were contradictory. There was a slight increase of the mean survival time (MST) in the F/344 → Bf combination; on the contrary, a sensitizing effect in the Bf → F/344 combination was observed. These results are discussed and interpreted on the basis of the hypothesis that other factors besides the exchange of antigens intervene in cross circulation.

Original languageEnglish
Pages (from-to)521-524
Number of pages4
Issue number6
Publication statusPublished - 1971

ASJC Scopus subject areas

  • Transplantation
  • Immunology


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