TY - JOUR
T1 - Donor lymphocyte infusion after allogeneic stem cell transplantation
AU - Castagna, Luca
AU - Sarina, Barbara
AU - Bramanti, Stefania
AU - Perseghin, Paolo
AU - Mariotti, Jacopo
AU - Morabito, Lucio
PY - 2016/6/1
Y1 - 2016/6/1
N2 - Allogeneic stem cell transplantation (allo-SCT) is considered the cornerstone in the treatment of several malignant and not malignant hematological diseases. However, relapse of hematological disease after allo-SCT is considered the most challenging point in the field. The risk can be reduced through optimal patients, donor and disease selection before allo-SCT, but harnessing donor immune system is an appealing way to treat or avoid disease relapse. Donor lymphocyte infusion (DLI) is a simple and effective therapy after allo-SCT. In this paper, the efficacy of DLI will be analyzed in different hematological diseases, focusing also on their therapeutic or pre-emptive use.
AB - Allogeneic stem cell transplantation (allo-SCT) is considered the cornerstone in the treatment of several malignant and not malignant hematological diseases. However, relapse of hematological disease after allo-SCT is considered the most challenging point in the field. The risk can be reduced through optimal patients, donor and disease selection before allo-SCT, but harnessing donor immune system is an appealing way to treat or avoid disease relapse. Donor lymphocyte infusion (DLI) is a simple and effective therapy after allo-SCT. In this paper, the efficacy of DLI will be analyzed in different hematological diseases, focusing also on their therapeutic or pre-emptive use.
KW - Allogeneic transplantation
KW - DLI
KW - Hematological disease
KW - Pre-emeptive
KW - Relapse
UR - http://www.scopus.com/inward/record.url?scp=84969531842&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84969531842&partnerID=8YFLogxK
U2 - 10.1016/j.transci.2016.05.011
DO - 10.1016/j.transci.2016.05.011
M3 - Article
AN - SCOPUS:84969531842
VL - 54
SP - 345
EP - 355
JO - Transfusion and Apheresis Science
JF - Transfusion and Apheresis Science
SN - 1473-0502
IS - 3
ER -