Donor-recipient incompatibility at CD31-codon 563 is a major risk factor for acute graft-versus-host disease after allogeneic bone marrow transplantation from a human leucocyte antigen-matched donor

C. L. Balduini, F. Frassoni, P. Noris, C. Klersy, A. M. Iannone, A. Bacigalupo, G. Giorgiani, M. Di Pumpo, F. Locatelli

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Disparities at minor histocompatibility antigens (mHA) are thought to be responsible for acute graft-versus-host disease (aGVHD) in patients receiving bone marrow transplantation (BMT) from a human leucocyte antigen (HLA)-matched donor. Although some mHA have been identified in humans, their role in aGVHD has not. Patients (n=150) receiving a BMT from an HLA-matched donor were investigated for a correlation between aGVHD and donor/recipient incompatibility for seven polymorphisms previously proposed for mHA (HA-1, H-Y, CD31-codon 125, CD31-codon 563, HPA-1, HPA-3 and HPA-5). Only mismatch at CD31-codon 563 predicted grade II-IV aGVHD. The risk derived from CD31-codon 563 mismatch was the same as that derived from the use of bone marrow from an unrelated donor. We suggest that donor/recipient compatibility at CD31-codon 563 should be added to HLA-typing for donor selection and/or adjustment of aGVHD prophylaxis.

Original languageEnglish
Pages (from-to)951-953
Number of pages3
JournalBritish Journal of Haematology
Volume114
Issue number4
DOIs
Publication statusPublished - 2001

Fingerprint

Homologous Transplantation
Graft vs Host Disease
HLA Antigens
Bone Marrow Transplantation
Codon
Minor Histocompatibility Antigens
Tissue Donors
Donor Selection
Unrelated Donors
Bone Marrow

Keywords

  • Acute graft-versus-host disease
  • Bone marrow transplantation
  • CD31
  • HA-1
  • Minor histocompatibility antigens

ASJC Scopus subject areas

  • Hematology

Cite this

@article{cb1d8a0626694d7a97c9e1911bd3e4ed,
title = "Donor-recipient incompatibility at CD31-codon 563 is a major risk factor for acute graft-versus-host disease after allogeneic bone marrow transplantation from a human leucocyte antigen-matched donor",
abstract = "Disparities at minor histocompatibility antigens (mHA) are thought to be responsible for acute graft-versus-host disease (aGVHD) in patients receiving bone marrow transplantation (BMT) from a human leucocyte antigen (HLA)-matched donor. Although some mHA have been identified in humans, their role in aGVHD has not. Patients (n=150) receiving a BMT from an HLA-matched donor were investigated for a correlation between aGVHD and donor/recipient incompatibility for seven polymorphisms previously proposed for mHA (HA-1, H-Y, CD31-codon 125, CD31-codon 563, HPA-1, HPA-3 and HPA-5). Only mismatch at CD31-codon 563 predicted grade II-IV aGVHD. The risk derived from CD31-codon 563 mismatch was the same as that derived from the use of bone marrow from an unrelated donor. We suggest that donor/recipient compatibility at CD31-codon 563 should be added to HLA-typing for donor selection and/or adjustment of aGVHD prophylaxis.",
keywords = "Acute graft-versus-host disease, Bone marrow transplantation, CD31, HA-1, Minor histocompatibility antigens",
author = "Balduini, {C. L.} and F. Frassoni and P. Noris and C. Klersy and Iannone, {A. M.} and A. Bacigalupo and G. Giorgiani and {Di Pumpo}, M. and F. Locatelli",
year = "2001",
doi = "10.1046/j.1365-2141.2001.03035.x",
language = "English",
volume = "114",
pages = "951--953",
journal = "British Journal of Haematology",
issn = "0007-1048",
publisher = "John Wiley & Sons, Ltd (10.1111)",
number = "4",

}

TY - JOUR

T1 - Donor-recipient incompatibility at CD31-codon 563 is a major risk factor for acute graft-versus-host disease after allogeneic bone marrow transplantation from a human leucocyte antigen-matched donor

AU - Balduini, C. L.

AU - Frassoni, F.

AU - Noris, P.

AU - Klersy, C.

AU - Iannone, A. M.

AU - Bacigalupo, A.

AU - Giorgiani, G.

AU - Di Pumpo, M.

AU - Locatelli, F.

PY - 2001

Y1 - 2001

N2 - Disparities at minor histocompatibility antigens (mHA) are thought to be responsible for acute graft-versus-host disease (aGVHD) in patients receiving bone marrow transplantation (BMT) from a human leucocyte antigen (HLA)-matched donor. Although some mHA have been identified in humans, their role in aGVHD has not. Patients (n=150) receiving a BMT from an HLA-matched donor were investigated for a correlation between aGVHD and donor/recipient incompatibility for seven polymorphisms previously proposed for mHA (HA-1, H-Y, CD31-codon 125, CD31-codon 563, HPA-1, HPA-3 and HPA-5). Only mismatch at CD31-codon 563 predicted grade II-IV aGVHD. The risk derived from CD31-codon 563 mismatch was the same as that derived from the use of bone marrow from an unrelated donor. We suggest that donor/recipient compatibility at CD31-codon 563 should be added to HLA-typing for donor selection and/or adjustment of aGVHD prophylaxis.

AB - Disparities at minor histocompatibility antigens (mHA) are thought to be responsible for acute graft-versus-host disease (aGVHD) in patients receiving bone marrow transplantation (BMT) from a human leucocyte antigen (HLA)-matched donor. Although some mHA have been identified in humans, their role in aGVHD has not. Patients (n=150) receiving a BMT from an HLA-matched donor were investigated for a correlation between aGVHD and donor/recipient incompatibility for seven polymorphisms previously proposed for mHA (HA-1, H-Y, CD31-codon 125, CD31-codon 563, HPA-1, HPA-3 and HPA-5). Only mismatch at CD31-codon 563 predicted grade II-IV aGVHD. The risk derived from CD31-codon 563 mismatch was the same as that derived from the use of bone marrow from an unrelated donor. We suggest that donor/recipient compatibility at CD31-codon 563 should be added to HLA-typing for donor selection and/or adjustment of aGVHD prophylaxis.

KW - Acute graft-versus-host disease

KW - Bone marrow transplantation

KW - CD31

KW - HA-1

KW - Minor histocompatibility antigens

UR - http://www.scopus.com/inward/record.url?scp=0034798255&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0034798255&partnerID=8YFLogxK

U2 - 10.1046/j.1365-2141.2001.03035.x

DO - 10.1046/j.1365-2141.2001.03035.x

M3 - Article

VL - 114

SP - 951

EP - 953

JO - British Journal of Haematology

JF - British Journal of Haematology

SN - 0007-1048

IS - 4

ER -