Donor-recipient incompatibility at CD31-codon 563 is a major risk factor for acute graft-versus-host disease after allogeneic bone marrow transplantation from a human leucocyte antigen-matched donor

C. L. Balduini, F. Frassoni, P. Noris, C. Klersy, A. M. Iannone, A. Bacigalupo, G. Giorgiani, M. Di Pumpo, F. Locatelli

Research output: Contribution to journalArticle

Abstract

Disparities at minor histocompatibility antigens (mHA) are thought to be responsible for acute graft-versus-host disease (aGVHD) in patients receiving bone marrow transplantation (BMT) from a human leucocyte antigen (HLA)-matched donor. Although some mHA have been identified in humans, their role in aGVHD has not. Patients (n=150) receiving a BMT from an HLA-matched donor were investigated for a correlation between aGVHD and donor/recipient incompatibility for seven polymorphisms previously proposed for mHA (HA-1, H-Y, CD31-codon 125, CD31-codon 563, HPA-1, HPA-3 and HPA-5). Only mismatch at CD31-codon 563 predicted grade II-IV aGVHD. The risk derived from CD31-codon 563 mismatch was the same as that derived from the use of bone marrow from an unrelated donor. We suggest that donor/recipient compatibility at CD31-codon 563 should be added to HLA-typing for donor selection and/or adjustment of aGVHD prophylaxis.

Original languageEnglish
Pages (from-to)951-953
Number of pages3
JournalBritish Journal of Haematology
Volume114
Issue number4
DOIs
Publication statusPublished - 2001

Keywords

  • Acute graft-versus-host disease
  • Bone marrow transplantation
  • CD31
  • HA-1
  • Minor histocompatibility antigens

ASJC Scopus subject areas

  • Hematology

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