Dopa-responsive pseudo-orthostatic tremor in Parkinsonism

Astrid Thomas, Laura Bonanni, Angelo Antonini, Paolo Barone, Marco Onofrj

Research output: Contribution to journalArticle

Abstract

In four patients an inabilitating standing tremor appeared years before that parkinsonian symptoms were evidenced. This tremor was refractory to gabapentin and dramatically responded to Levodopa administration. Its dominant frequency was 6.2 to 6.9 Hz with sporadic sub-harmonics at 8 to 18 Hz. Three patients were affected by different genetic mutations (Park 2, Park 6, mtDNA deletion) in one no genetic or metabolic alterations could be evidenced. All patients had dopamine transporter abnormalities. We suggest that the term "Pseudo-Orthostatic Tremor" could be used to define this Dopa responsive, 6 to 7 Hz standing tremor.

Original languageEnglish
Pages (from-to)1652-1656
Number of pages5
JournalMovement Disorders
Volume22
Issue number11
DOIs
Publication statusPublished - Aug 15 2007

Keywords

  • Gabapentin
  • L-dopa
  • Orthostatic tremor
  • Parkinson disease

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)

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    Thomas, A., Bonanni, L., Antonini, A., Barone, P., & Onofrj, M. (2007). Dopa-responsive pseudo-orthostatic tremor in Parkinsonism. Movement Disorders, 22(11), 1652-1656. https://doi.org/10.1002/mds.21621