Dopa-responsive pseudo-orthostatic tremor in Parkinsonism

Astrid Thomas, Laura Bonanni, Angelo Antonini, Paolo Barone, Marco Onofrj

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

In four patients an inabilitating standing tremor appeared years before that parkinsonian symptoms were evidenced. This tremor was refractory to gabapentin and dramatically responded to Levodopa administration. Its dominant frequency was 6.2 to 6.9 Hz with sporadic sub-harmonics at 8 to 18 Hz. Three patients were affected by different genetic mutations (Park 2, Park 6, mtDNA deletion) in one no genetic or metabolic alterations could be evidenced. All patients had dopamine transporter abnormalities. We suggest that the term "Pseudo-Orthostatic Tremor" could be used to define this Dopa responsive, 6 to 7 Hz standing tremor.

Original languageEnglish
Pages (from-to)1652-1656
Number of pages5
JournalMovement Disorders
Volume22
Issue number11
DOIs
Publication statusPublished - Aug 15 2007

Fingerprint

Dihydroxyphenylalanine
Parkinsonian Disorders
Tremor
Dopamine Plasma Membrane Transport Proteins
Levodopa
Mitochondrial DNA
Mutation

Keywords

  • Gabapentin
  • L-dopa
  • Orthostatic tremor
  • Parkinson disease

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)

Cite this

Thomas, A., Bonanni, L., Antonini, A., Barone, P., & Onofrj, M. (2007). Dopa-responsive pseudo-orthostatic tremor in Parkinsonism. Movement Disorders, 22(11), 1652-1656. https://doi.org/10.1002/mds.21621

Dopa-responsive pseudo-orthostatic tremor in Parkinsonism. / Thomas, Astrid; Bonanni, Laura; Antonini, Angelo; Barone, Paolo; Onofrj, Marco.

In: Movement Disorders, Vol. 22, No. 11, 15.08.2007, p. 1652-1656.

Research output: Contribution to journalArticle

Thomas, A, Bonanni, L, Antonini, A, Barone, P & Onofrj, M 2007, 'Dopa-responsive pseudo-orthostatic tremor in Parkinsonism', Movement Disorders, vol. 22, no. 11, pp. 1652-1656. https://doi.org/10.1002/mds.21621
Thomas A, Bonanni L, Antonini A, Barone P, Onofrj M. Dopa-responsive pseudo-orthostatic tremor in Parkinsonism. Movement Disorders. 2007 Aug 15;22(11):1652-1656. https://doi.org/10.1002/mds.21621
Thomas, Astrid ; Bonanni, Laura ; Antonini, Angelo ; Barone, Paolo ; Onofrj, Marco. / Dopa-responsive pseudo-orthostatic tremor in Parkinsonism. In: Movement Disorders. 2007 ; Vol. 22, No. 11. pp. 1652-1656.
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