Dopamine agonist amineptine prevents the antidepressant effect of sleep deprivation

Francesco Benedetti, Barbara Barbini, Euridice Campori, Cristina Colombo, Enrico Smeraldi

Research output: Contribution to journalArticlepeer-review


In a double-blind study, the effects of the interaction between the administration of amineptine versus placebo and repeated cycles of total sleep deprivation (TSD), which is thought to act through an enhancement in dopaminergic transmission, were analyzed. Twenty-two consecutively admitted patients with bipolar depression formed the study group. Repeated administrations of TSD significantly enhanced perceived mood levels in placebo-treated patients, while amineptine administration blocked the antidepressant action of TSD. Hypothesized changes in brain dopaminergic transmission attributable to amineptine pretreatment are discussed.

Original languageEnglish
Pages (from-to)179-184
Number of pages6
JournalPsychiatry Research
Issue number3
Publication statusPublished - Dec 20 1996


  • affective disorder
  • bipolar subtype
  • mania
  • mood

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry
  • Psychology(all)


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