Dopamine and frusemide in oliguric acute renal failure

G. Graziani, A. Cantaluppi, S. Casati, A. Citterio, A. Scalamogna, A. Aroldi, R. Silenzio, D. Brancaccio, C. Ponticelli

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Abstract

Into 24 oliguric patients with acute renal failure (ARF) for whom mannitol and high-dose frusemide had failed to promote a diuresis, dopamine (3 μg/kg/min) plus frusemide (10-15 mg/kg/h) were infused for 6-24 h. In 19 of the 24 patients this treatment produced significant increases in diuresis (from 11 ± 7 to 85 ± 51 ml/h; p <0.001) and natriuresis (from 45 ± 13 to 88 ± 22 mEq/l; p <0.001), without any significant modification of blood pressure, pulse rate or central venous pressure. 10 of the 24 patients required dialysis: 5 because therapy failed to promote diuresis and the other 5 because of their hypercatabolic state in spite of polyuria. 5 patients died of causes unrelated to ARF. Since all patients who responded were treated within 24 h after the onset of oliguria, it appears to be crucial to administer dopamine and frusemide early, before more severe anatomical and functional damage develops.

Original languageEnglish
Pages (from-to)39-42
Number of pages4
JournalNephron
Volume37
Issue number1
Publication statusPublished - 1984

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Furosemide
Acute Kidney Injury
Dopamine
Diuresis
Oliguria
Polyuria
Natriuresis
Central Venous Pressure
Mannitol
Dialysis
Heart Rate
Blood Pressure
Therapeutics

ASJC Scopus subject areas

  • Nephrology

Cite this

Graziani, G., Cantaluppi, A., Casati, S., Citterio, A., Scalamogna, A., Aroldi, A., ... Ponticelli, C. (1984). Dopamine and frusemide in oliguric acute renal failure. Nephron, 37(1), 39-42.

Dopamine and frusemide in oliguric acute renal failure. / Graziani, G.; Cantaluppi, A.; Casati, S.; Citterio, A.; Scalamogna, A.; Aroldi, A.; Silenzio, R.; Brancaccio, D.; Ponticelli, C.

In: Nephron, Vol. 37, No. 1, 1984, p. 39-42.

Research output: Contribution to journalArticle

Graziani, G, Cantaluppi, A, Casati, S, Citterio, A, Scalamogna, A, Aroldi, A, Silenzio, R, Brancaccio, D & Ponticelli, C 1984, 'Dopamine and frusemide in oliguric acute renal failure', Nephron, vol. 37, no. 1, pp. 39-42.
Graziani G, Cantaluppi A, Casati S, Citterio A, Scalamogna A, Aroldi A et al. Dopamine and frusemide in oliguric acute renal failure. Nephron. 1984;37(1):39-42.
Graziani, G. ; Cantaluppi, A. ; Casati, S. ; Citterio, A. ; Scalamogna, A. ; Aroldi, A. ; Silenzio, R. ; Brancaccio, D. ; Ponticelli, C. / Dopamine and frusemide in oliguric acute renal failure. In: Nephron. 1984 ; Vol. 37, No. 1. pp. 39-42.
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AU - Aroldi, A.

AU - Silenzio, R.

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