The role of the dopaminergic system in the mechanisms of migraine, first investigated more than 20 years ago, is still controversial, but recent evidence from genetic studies suggests that migraine heterogeneity may be strictly associated with the different allelic expression of the dopaminergic receptor (D2) gene. In concert with neuroanatomical data, this has shed new light on the body of clinical, neuroendocrine, neurobiochemical, neuropharmacological and neurophysiological data obtained over the past years on the involvement of dopamine (DA) in migraine. The study of DA appears to be more relevant to both migraine as a 'disease' and migraine as 'attacks', whereas prostaglandins (PGs) have only been involved in the latter case, i.e. in the mechanisms underlying the painful and non painful phenomena of the recurrent migraine episodes. Here we critically review the main data concerning the possible roles of DA and PGs in migraine, and their implications for the acute and prophylactic treatments of this disease.
|Translated title of the contribution||Dopamine and prostaglandins in in migraine pathogenesis: A review|
|Number of pages||9|
|Publication status||Published - 2000|
ASJC Scopus subject areas
- Clinical Neurology