RUOLO DELLA DOPAMINA E DEL VIP NELLA PATOGENESI DELL'ACALASIA ESOFAGEA

Translated title of the contribution: Dopamine and VIP are involved in esophageal achalasia

G. Missale, R. Cestari, L. Lojacono, S. Sigala, C. Missale, P. F. Spano, V. Villanacci, P. G. Grigolato

Research output: Contribution to journalArticle

Abstract

Clinical and pharmacological evidence suggests that several neurotransmitters are involved in the control of the esophageal motility. Esophageal achalasia is a neuromuscular disorder characterized by the absence of peristalsis in the body of the esophagus and by the failure of the LES to relax in response to swallowing. Stimulation of both VIP receptors and D-2 DA receptors induce a decrease in LES pressure, while D-1 receptors mediate LES contractions. In the present study we show that both VIP and DA system is disregulated in LES achalasia. In particular, this disease is associated not only with the lack of VIP nerves in the LES, but also with a failure in the responsiveness of postsynaptic receptors to VIP stimulation. Furthermore, we demonstrate a selective functional loss of the D-2 DA receptors component, without changes in the D-1 DA receptor mediated responses.

Original languageItalian
Pages (from-to)347-356
Number of pages10
JournalActa Chirurgica Italica
Volume51
Issue number4
Publication statusPublished - 1995

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Vasoactive Intestinal Peptide Receptors
Esophageal Achalasia
Dopamine
Peristalsis
Deglutition
Esophagus
Neurotransmitter Agents
Pharmacology
Pressure

ASJC Scopus subject areas

  • Surgery

Cite this

Missale, G., Cestari, R., Lojacono, L., Sigala, S., Missale, C., Spano, P. F., ... Grigolato, P. G. (1995). RUOLO DELLA DOPAMINA E DEL VIP NELLA PATOGENESI DELL'ACALASIA ESOFAGEA. Acta Chirurgica Italica, 51(4), 347-356.

RUOLO DELLA DOPAMINA E DEL VIP NELLA PATOGENESI DELL'ACALASIA ESOFAGEA. / Missale, G.; Cestari, R.; Lojacono, L.; Sigala, S.; Missale, C.; Spano, P. F.; Villanacci, V.; Grigolato, P. G.

In: Acta Chirurgica Italica, Vol. 51, No. 4, 1995, p. 347-356.

Research output: Contribution to journalArticle

Missale, G, Cestari, R, Lojacono, L, Sigala, S, Missale, C, Spano, PF, Villanacci, V & Grigolato, PG 1995, 'RUOLO DELLA DOPAMINA E DEL VIP NELLA PATOGENESI DELL'ACALASIA ESOFAGEA', Acta Chirurgica Italica, vol. 51, no. 4, pp. 347-356.
Missale G, Cestari R, Lojacono L, Sigala S, Missale C, Spano PF et al. RUOLO DELLA DOPAMINA E DEL VIP NELLA PATOGENESI DELL'ACALASIA ESOFAGEA. Acta Chirurgica Italica. 1995;51(4):347-356.
Missale, G. ; Cestari, R. ; Lojacono, L. ; Sigala, S. ; Missale, C. ; Spano, P. F. ; Villanacci, V. ; Grigolato, P. G. / RUOLO DELLA DOPAMINA E DEL VIP NELLA PATOGENESI DELL'ACALASIA ESOFAGEA. In: Acta Chirurgica Italica. 1995 ; Vol. 51, No. 4. pp. 347-356.
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