Dopamine D2, D3, and D4 receptor mRNA levels in rat brain and pituitary during aging

Alessandra Valerio, Marco Belloni, Maria Luisa Gorno, Cristina Tinti, Maurizio Memo, Pierfranco Spano

Research output: Contribution to journalArticle

Abstract

Reverse Transcriptase-Polymerase Chain Reaction technique was used to determine the levels of the mRNAs encoding different receptors belonging to the D2 family in various brain areas of 6-, 12-, 18-, and 24-month-old rats. We found a progressive, age-dependent reduction in the mRNA levels of D2 short and D2 long receptors in corpus striatum, substantia nigra, and frontal cortex. D2 short and D2 long receptor mRNA levels were unchanged in hippocampus and olfactory tubercle, while they increased in pituitary. D3 receptor mRNA levels were reduced in olfactory tubercle and unchanged in striatum. D4 receptor mRNA levels were unmodified in pituitary gland. These data suggest that the molecular mechanisms responsible for regulating the pattern of expression of the various dopamine receptors are differentially regulated by aging.

Original languageEnglish
Pages (from-to)713-719
Number of pages7
JournalNeurobiology of Aging
Volume15
Issue number6
DOIs
Publication statusPublished - 1994

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Keywords

  • Aging
  • Dopamine receptors
  • mRNA
  • Polymerase chain reaction
  • Rat brain and pituitary

ASJC Scopus subject areas

  • Clinical Neurology
  • Biological Psychiatry
  • Developmental Neuroscience
  • Neurology
  • Psychology(all)

Cite this

Valerio, A., Belloni, M., Gorno, M. L., Tinti, C., Memo, M., & Spano, P. (1994). Dopamine D2, D3, and D4 receptor mRNA levels in rat brain and pituitary during aging. Neurobiology of Aging, 15(6), 713-719. https://doi.org/10.1016/0197-4580(94)90053-1