Dopamine D4 Receptor (DRD4) in the determination of Infant Temperament

A. DeLuca, I. Torrente, M. Mangino, F. Capon, M. Rizzardi, G. P. Salvioli, R. Allessandroni, G. Novelli, B. Dallapiccola

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Temperament dimensions are developmental phenomena affected by genetic and environmental factors to varying extent. During development some behaviors can appear, others can disappear, while still others remain continuous and, during the course of development, become more differ-entiated. In order to minimize environmental influences we have examined the relationship between the common Dopamine D4 Receptor (D4DR) exon III repeat polymorphism and infants behavior measured with the Italian version of the scale Early Infancy Temperament Questionnaire (EITQ). Temperament dimensions were assessed in 142 Italian infants at 50 days and 5.5 months of life to follow their relationship with D4DR gene during development. Two-way ANOVAs (genotype x age) were computed for each of the EITQ dimensions. A significant correlation was evidenced with the EITQ trait of Adaptability [F(1,120)=5.26, p

Original languageEnglish
Pages (from-to)472
Number of pages1
JournalAmerican Journal of Medical Genetics - Neuropsychiatric Genetics
Issue number4
Publication statusPublished - Aug 7 2000

ASJC Scopus subject areas

  • Genetics(clinical)
  • Neuropsychology and Physiological Psychology
  • Neuroscience(all)


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