Dopamine D4 receptor (DRD4) polymorphism and adaptability trait during infancy: A longitudinal study in 1- to 5-month-old neonates

Alessandro De Luca, Mario Rizzardi, Isabella Torrente, Rosa Alessandroni, Gian Paolo Salvioli, Nando Filograsso, Bruno Dallapiccola, Giuseppe Novelli

Research output: Contribution to journalArticle

Abstract

We have examined the relationship between the common dopamine D4 receptor (DRD4) exon III repeat polymorphism and infants' behavior measured with the Italian version of the Early and Revised Infancy Temperament Questionnaires (EITQ/RITQ) in 122 Italian neonates at 1 and 5 months of life, when the genetic contribution to the behavior can be more clearly assessed. Two-way (genotype x age) analysis of variance revealed a significant correlation with the temperamental subscale of adaptability [F(1, 120) = 5.26, P <0.02]. At 1 month of life (early assessment), infants with long (L) DRD4 alleles presented significantly low scores (L 2.61 ± 0.073; S 2.84 + 0.79; Newman-Keuls P = 0.03) in comparison with the high scores of infants with short (S) alleles (L 2.4 ± 0.059; S 2.25 ± 0.57). These differences were not detected at 5 months of life (late assessment), denoting a strong environmental effect at this age on the genetic background. These results confirm and extend the genetic influence of the DRD4 gene in human temperament at birth.

Original languageEnglish
Pages (from-to)79-82
Number of pages4
JournalNeurogenetics
Volume3
Issue number2
DOIs
Publication statusPublished - 2001

Fingerprint

Dopamine D4 Receptors
Longitudinal Studies
Temperament
Newborn Infant
Alleles
Infant Behavior
Exons
Analysis of Variance
Genotype
Parturition
Genes

Keywords

  • Adaptability
  • Dopamine D4 receptor
  • Personality
  • Polymorphism
  • Temperament

ASJC Scopus subject areas

  • Genetics(clinical)
  • Neuroscience(all)

Cite this

Dopamine D4 receptor (DRD4) polymorphism and adaptability trait during infancy : A longitudinal study in 1- to 5-month-old neonates. / De Luca, Alessandro; Rizzardi, Mario; Torrente, Isabella; Alessandroni, Rosa; Salvioli, Gian Paolo; Filograsso, Nando; Dallapiccola, Bruno; Novelli, Giuseppe.

In: Neurogenetics, Vol. 3, No. 2, 2001, p. 79-82.

Research output: Contribution to journalArticle

De Luca, Alessandro ; Rizzardi, Mario ; Torrente, Isabella ; Alessandroni, Rosa ; Salvioli, Gian Paolo ; Filograsso, Nando ; Dallapiccola, Bruno ; Novelli, Giuseppe. / Dopamine D4 receptor (DRD4) polymorphism and adaptability trait during infancy : A longitudinal study in 1- to 5-month-old neonates. In: Neurogenetics. 2001 ; Vol. 3, No. 2. pp. 79-82.
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