Dopamine denervation of the nucleus accumbens induces a selective increase in the number of δ-opioid binding sites

E. Esposito, L. Cervo, P. Petrillo, M. Sbacchi, A. Tavani, R. Samanin

Research output: Contribution to journalArticle

Abstract

Selective lesions of dopamine (DA) neurons of the nucleus accumbens were made in rats by local injections of 6-hydroxydopamine (6-OHDA). Seven days after 6-OHDA, the binding affinities and capacities at μ-, δ- and κ-opioid binding sites were determined in the nucleus accumbens by selective labelling techniques. 6-OHDA pretreatment caused a significant increase in the number of δ-opioid binding sites (+30%) while the number of μ-, κ- and total sites was not modified. The affinity at μ-, δ- and κ-sites was unchanges after 6-OHDA pretreatment.

Original languageEnglish
Pages (from-to)25-29
Number of pages5
JournalBrain Research
Volume436
Issue number1
DOIs
Publication statusPublished - Dec 8 1987

Keywords

  • 6-Hydroxydopamine lesion
  • Hypersensitivity
  • Nucleus accumbens
  • Opioid receptor
  • Rat

ASJC Scopus subject areas

  • Developmental Biology
  • Molecular Biology
  • Clinical Neurology
  • Neuroscience(all)

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