Dopamine denervation of the nucleus accumbens induces a selective increase in the number of δ-opioid binding sites

E. Esposito, L. Cervo, P. Petrillo, M. Sbacchi, A. Tavani, R. Samanin

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Selective lesions of dopamine (DA) neurons of the nucleus accumbens were made in rats by local injections of 6-hydroxydopamine (6-OHDA). Seven days after 6-OHDA, the binding affinities and capacities at μ-, δ- and κ-opioid binding sites were determined in the nucleus accumbens by selective labelling techniques. 6-OHDA pretreatment caused a significant increase in the number of δ-opioid binding sites (+30%) while the number of μ-, κ- and total sites was not modified. The affinity at μ-, δ- and κ-sites was unchanges after 6-OHDA pretreatment.

Original languageEnglish
Pages (from-to)25-29
Number of pages5
JournalBrain Research
Volume436
Issue number1
DOIs
Publication statusPublished - Dec 8 1987

Fingerprint

Oxidopamine
Nucleus Accumbens
Denervation
Opioid Analgesics
Dopamine
Binding Sites
Dopaminergic Neurons
Injections

Keywords

  • 6-Hydroxydopamine lesion
  • Hypersensitivity
  • Nucleus accumbens
  • Opioid receptor
  • Rat

ASJC Scopus subject areas

  • Developmental Biology
  • Molecular Biology
  • Clinical Neurology
  • Neuroscience(all)

Cite this

Dopamine denervation of the nucleus accumbens induces a selective increase in the number of δ-opioid binding sites. / Esposito, E.; Cervo, L.; Petrillo, P.; Sbacchi, M.; Tavani, A.; Samanin, R.

In: Brain Research, Vol. 436, No. 1, 08.12.1987, p. 25-29.

Research output: Contribution to journalArticle

Esposito, E. ; Cervo, L. ; Petrillo, P. ; Sbacchi, M. ; Tavani, A. ; Samanin, R. / Dopamine denervation of the nucleus accumbens induces a selective increase in the number of δ-opioid binding sites. In: Brain Research. 1987 ; Vol. 436, No. 1. pp. 25-29.
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