Dopamine enhances Met-enkephalin efflux from rat striatal slices

G. Pasinetti, S. Govoni, S. Di Giovine, P. F. Spano, M. Trabucchi

Research output: Contribution to journalArticlepeer-review


The basal release of Met-enkephalin immunoreactive material (ME-IR) from rat striatal slices is doubled by the in vitro addition of 5 × 10-5 M dopamine. The K+ evoked release of ME-IR is alsoslightly enhanced by exposing the slices to dopamine. The effect of dopamine is shared by apomorphine but not by norepinephrine. Neuroleptics do not alter the basal or the K+-stimulated ME-IR release but reverse the dopamine-induced increase. These results suggest that the stimulation of dopamine receptors may influence the enkephalin release within striatum.

Original languageEnglish
Pages (from-to)364-367
Number of pages4
JournalBrain Research
Issue number2
Publication statusPublished - Feb 20 1984


  • dopamine
  • Met-enkephalin
  • striatum

ASJC Scopus subject areas

  • Developmental Biology
  • Molecular Biology
  • Clinical Neurology
  • Neuroscience(all)


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