Dopamine enhances Met-enkephalin efflux from rat striatal slices

G. Pasinetti; S. Govoni; S. Di Giovine; P. F. Spano; M. Trabucchi

doi:10.1016/0006-8993(84)91244-7

Dopamine enhances Met-enkephalin efflux from rat striatal slices

G. Pasinetti, S. Govoni, S. Di Giovine, P. F. Spano, M. Trabucchi

Istituto di Neuroriabilitazione Motoria San Camillo

Research output: Contribution to journal › Article › peer-review

Abstract

The basal release of Met-enkephalin immunoreactive material (ME-IR) from rat striatal slices is doubled by the in vitro addition of 5 × 10^-5 M dopamine. The K⁺ evoked release of ME-IR is alsoslightly enhanced by exposing the slices to dopamine. The effect of dopamine is shared by apomorphine but not by norepinephrine. Neuroleptics do not alter the basal or the K⁺-stimulated ME-IR release but reverse the dopamine-induced increase. These results suggest that the stimulation of dopamine receptors may influence the enkephalin release within striatum.

Original language	English
Pages (from-to)	364-367
Number of pages	4
Journal	Brain Research
Volume	293
Issue number	2
DOIs	https://doi.org/10.1016/0006-8993(84)91244-7
Publication status	Published - Feb 20 1984

Keywords

dopamine
Met-enkephalin
striatum

ASJC Scopus subject areas

Developmental Biology
Molecular Biology
Clinical Neurology
Neuroscience(all)

Access to Document

10.1016/0006-8993(84)91244-7

Cite this

@article{2c88711cd2de4baca2f12e6638a40e80,

title = "Dopamine enhances Met-enkephalin efflux from rat striatal slices",

abstract = "The basal release of Met-enkephalin immunoreactive material (ME-IR) from rat striatal slices is doubled by the in vitro addition of 5 × 10-5 M dopamine. The K+ evoked release of ME-IR is alsoslightly enhanced by exposing the slices to dopamine. The effect of dopamine is shared by apomorphine but not by norepinephrine. Neuroleptics do not alter the basal or the K+-stimulated ME-IR release but reverse the dopamine-induced increase. These results suggest that the stimulation of dopamine receptors may influence the enkephalin release within striatum.",

keywords = "dopamine, Met-enkephalin, striatum",

author = "G. Pasinetti and S. Govoni and {Di Giovine}, S. and Spano, {P. F.} and M. Trabucchi",

year = "1984",

month = feb,

day = "20",

doi = "10.1016/0006-8993(84)91244-7",

language = "English",

volume = "293",

pages = "364--367",

journal = "Brain Research",

issn = "0006-8993",

publisher = "Elsevier",

number = "2",

}

TY - JOUR

T1 - Dopamine enhances Met-enkephalin efflux from rat striatal slices

AU - Pasinetti, G.

AU - Govoni, S.

AU - Di Giovine, S.

AU - Spano, P. F.

AU - Trabucchi, M.

PY - 1984/2/20

Y1 - 1984/2/20

N2 - The basal release of Met-enkephalin immunoreactive material (ME-IR) from rat striatal slices is doubled by the in vitro addition of 5 × 10-5 M dopamine. The K+ evoked release of ME-IR is alsoslightly enhanced by exposing the slices to dopamine. The effect of dopamine is shared by apomorphine but not by norepinephrine. Neuroleptics do not alter the basal or the K+-stimulated ME-IR release but reverse the dopamine-induced increase. These results suggest that the stimulation of dopamine receptors may influence the enkephalin release within striatum.

AB - The basal release of Met-enkephalin immunoreactive material (ME-IR) from rat striatal slices is doubled by the in vitro addition of 5 × 10-5 M dopamine. The K+ evoked release of ME-IR is alsoslightly enhanced by exposing the slices to dopamine. The effect of dopamine is shared by apomorphine but not by norepinephrine. Neuroleptics do not alter the basal or the K+-stimulated ME-IR release but reverse the dopamine-induced increase. These results suggest that the stimulation of dopamine receptors may influence the enkephalin release within striatum.

KW - dopamine

KW - Met-enkephalin

KW - striatum

UR - http://www.scopus.com/inward/record.url?scp=0021345616&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0021345616&partnerID=8YFLogxK

U2 - 10.1016/0006-8993(84)91244-7

DO - 10.1016/0006-8993(84)91244-7

M3 - Article

C2 - 6697225

AN - SCOPUS:0021345616

VL - 293

SP - 364

EP - 367

JO - Brain Research

JF - Brain Research

SN - 0006-8993

IS - 2

ER -

Dopamine enhances Met-enkephalin efflux from rat striatal slices

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this