Dopamine enhances Met-enkephalin efflux from rat striatal slices

G. Pasinetti; S. Govoni; S. Di Giovine; P. F. Spano; M. Trabucchi

doi:10.1016/0006-8993(84)91244-7

Dopamine enhances Met-enkephalin efflux from rat striatal slices

G. Pasinetti, S. Govoni, S. Di Giovine, P. F. Spano, M. Trabucchi

Istituto di Neuroriabilitazione Motoria San Camillo

Research output: Contribution to journal › Article › peer-review

Abstract

The basal release of Met-enkephalin immunoreactive material (ME-IR) from rat striatal slices is doubled by the in vitro addition of 5 × 10^-5 M dopamine. The K⁺ evoked release of ME-IR is alsoslightly enhanced by exposing the slices to dopamine. The effect of dopamine is shared by apomorphine but not by norepinephrine. Neuroleptics do not alter the basal or the K⁺-stimulated ME-IR release but reverse the dopamine-induced increase. These results suggest that the stimulation of dopamine receptors may influence the enkephalin release within striatum.

Original language	English
Pages (from-to)	364-367
Number of pages	4
Journal	Brain Research
Volume	293
Issue number	2
DOIs	https://doi.org/10.1016/0006-8993(84)91244-7
Publication status	Published - Feb 20 1984

Keywords

dopamine
Met-enkephalin
striatum

ASJC Scopus subject areas

Developmental Biology
Molecular Biology
Clinical Neurology
Neuroscience(all)

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abstract = "The basal release of Met-enkephalin immunoreactive material (ME-IR) from rat striatal slices is doubled by the in vitro addition of 5 × 10-5 M dopamine. The K+ evoked release of ME-IR is alsoslightly enhanced by exposing the slices to dopamine. The effect of dopamine is shared by apomorphine but not by norepinephrine. Neuroleptics do not alter the basal or the K+-stimulated ME-IR release but reverse the dopamine-induced increase. These results suggest that the stimulation of dopamine receptors may influence the enkephalin release within striatum.",

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AU - Pasinetti, G.

AU - Govoni, S.

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AU - Spano, P. F.

AU - Trabucchi, M.

PY - 1984/2/20

Y1 - 1984/2/20

N2 - The basal release of Met-enkephalin immunoreactive material (ME-IR) from rat striatal slices is doubled by the in vitro addition of 5 × 10-5 M dopamine. The K+ evoked release of ME-IR is alsoslightly enhanced by exposing the slices to dopamine. The effect of dopamine is shared by apomorphine but not by norepinephrine. Neuroleptics do not alter the basal or the K+-stimulated ME-IR release but reverse the dopamine-induced increase. These results suggest that the stimulation of dopamine receptors may influence the enkephalin release within striatum.

AB - The basal release of Met-enkephalin immunoreactive material (ME-IR) from rat striatal slices is doubled by the in vitro addition of 5 × 10-5 M dopamine. The K+ evoked release of ME-IR is alsoslightly enhanced by exposing the slices to dopamine. The effect of dopamine is shared by apomorphine but not by norepinephrine. Neuroleptics do not alter the basal or the K+-stimulated ME-IR release but reverse the dopamine-induced increase. These results suggest that the stimulation of dopamine receptors may influence the enkephalin release within striatum.

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KW - Met-enkephalin

KW - striatum

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Dopamine enhances Met-enkephalin efflux from rat striatal slices

Abstract

Keywords

ASJC Scopus subject areas

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