Abstract
We previously reported an association between dopamine receptor D4 (DRD4) gene exon 1 variants and delusional disorder. The aim of this investigation was to study the DRD4 gene exon 1 and 3 variants in schizophrenia, delusional, bipolar, and unipolar disorders. We studied 651 inpatients affected by schizophrenia (n = 229), delusional (n = 86), bipolar (n = 210), and unipolar (n = 126) disorders (DSM III-R) and 471 healthy controls; these were typed for DRD4 variants at the first and third exon using polymerase chain reaction techniques. DRD4 variants were not associated with schizophrenic and delusional subjects even when possible confounders like gender and onset were considered. A marginal association between DRD4 exon 3 variants with unipolar (excess of DRD4*2/4, p = 0.004) and bipolar (excess of DRD4*2/4, p = 0.001) disorders was observed, both associations drop to insignificance when corrected for multiple testing. Our results exclude that coding variants of the DRD4 exon 1 and 3 may play a major role in conferring susceptibility to major psychoses; moreover, we could not replicate the association of DRD4 exon 1 variant with delusional disorder.
| Original language | English |
|---|---|
| Pages (from-to) | 486-491 |
| Number of pages | 6 |
| Journal | American Journal of Medical Genetics - Neuropsychiatric Genetics |
| Volume | 88 |
| Issue number | 5 |
| DOIs | |
| Publication status | Published - Oct 15 1999 |
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Keywords
- Bipolar disorder
- Depressive disorder
- Dopamine receptors
- Linkage disequilibrium
- Paranoid disorder
- Schizophrenia
ASJC Scopus subject areas
- Genetics(clinical)
- Neuropsychology and Physiological Psychology
- Neuroscience(all)
Cite this
Dopamine receptor D4 gene is not associated with major psychoses. / Serretti, Alessandro; Lilli, Roberta; Di Bella, Daniela; Bertelli, Sara; Nobile, Maria; Novelli, Emanuela; Catalano, Marco; Smeraldi, Enrico.
In: American Journal of Medical Genetics - Neuropsychiatric Genetics, Vol. 88, No. 5, 15.10.1999, p. 486-491.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Dopamine receptor D4 gene is not associated with major psychoses
AU - Serretti, Alessandro
AU - Lilli, Roberta
AU - Di Bella, Daniela
AU - Bertelli, Sara
AU - Nobile, Maria
AU - Novelli, Emanuela
AU - Catalano, Marco
AU - Smeraldi, Enrico
PY - 1999/10/15
Y1 - 1999/10/15
N2 - We previously reported an association between dopamine receptor D4 (DRD4) gene exon 1 variants and delusional disorder. The aim of this investigation was to study the DRD4 gene exon 1 and 3 variants in schizophrenia, delusional, bipolar, and unipolar disorders. We studied 651 inpatients affected by schizophrenia (n = 229), delusional (n = 86), bipolar (n = 210), and unipolar (n = 126) disorders (DSM III-R) and 471 healthy controls; these were typed for DRD4 variants at the first and third exon using polymerase chain reaction techniques. DRD4 variants were not associated with schizophrenic and delusional subjects even when possible confounders like gender and onset were considered. A marginal association between DRD4 exon 3 variants with unipolar (excess of DRD4*2/4, p = 0.004) and bipolar (excess of DRD4*2/4, p = 0.001) disorders was observed, both associations drop to insignificance when corrected for multiple testing. Our results exclude that coding variants of the DRD4 exon 1 and 3 may play a major role in conferring susceptibility to major psychoses; moreover, we could not replicate the association of DRD4 exon 1 variant with delusional disorder.
AB - We previously reported an association between dopamine receptor D4 (DRD4) gene exon 1 variants and delusional disorder. The aim of this investigation was to study the DRD4 gene exon 1 and 3 variants in schizophrenia, delusional, bipolar, and unipolar disorders. We studied 651 inpatients affected by schizophrenia (n = 229), delusional (n = 86), bipolar (n = 210), and unipolar (n = 126) disorders (DSM III-R) and 471 healthy controls; these were typed for DRD4 variants at the first and third exon using polymerase chain reaction techniques. DRD4 variants were not associated with schizophrenic and delusional subjects even when possible confounders like gender and onset were considered. A marginal association between DRD4 exon 3 variants with unipolar (excess of DRD4*2/4, p = 0.004) and bipolar (excess of DRD4*2/4, p = 0.001) disorders was observed, both associations drop to insignificance when corrected for multiple testing. Our results exclude that coding variants of the DRD4 exon 1 and 3 may play a major role in conferring susceptibility to major psychoses; moreover, we could not replicate the association of DRD4 exon 1 variant with delusional disorder.
KW - Bipolar disorder
KW - Depressive disorder
KW - Dopamine receptors
KW - Linkage disequilibrium
KW - Paranoid disorder
KW - Schizophrenia
UR - http://www.scopus.com/inward/record.url?scp=0033569902&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0033569902&partnerID=8YFLogxK
U2 - 10.1002/(SICI)1096-8628(19991015)88:5<486::AID-AJMG10>3.0.CO;2-P
DO - 10.1002/(SICI)1096-8628(19991015)88:5<486::AID-AJMG10>3.0.CO;2-P
M3 - Article
VL - 88
SP - 486
EP - 491
JO - American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics
JF - American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics
SN - 1552-4841
IS - 5
ER -