Dopamine receptor mRNAs in the rat lymphocytes

Brunella Caronti, Caterina Calderaro, Francesca Passarelli, Guido Palladini, Francesco E. Pontieri

Research output: Contribution to journalArticlepeer-review

Abstract

It has been suggested that dopamine might play a role in the regulation of the immune system. In this study, reverse transcriptase-polymerase chain reaction (RT-PCR) was used to investigate the expression of mRNA for the different subtypes of dopamine receptors in the rat lymphocytes. D1, D3 and D5 receptor mRNAs were identified. These results provide further evidence for the interaction of dopamine systems and the immune system, and suggest to further investigate whether the immunosuppressive actions of dopamine and dopaminergic drugs might depend on a direct interaction with dopamine receptors on the lymphocyte membrane. Moreover, they suggest the suitability of this animal species to further investigate the correlation between changes in the expression of central and peripheral dopamine receptors produced by manipulations of the dopamine systems.

Original languageEnglish
Pages (from-to)1919-1925
Number of pages7
JournalLife Sciences
Volume62
Issue number21
DOIs
Publication statusPublished - Apr 17 1998

Keywords

  • Dopamine receptor
  • Lymphocytes
  • MRNA

ASJC Scopus subject areas

  • Pharmacology

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