Dopamine receptors: Pharmacological and anatomical evidences indicate that two distinct dopamine receptor populations are present in rat striatum

L. Garau, S. Govoni, E. Stefanini, M. Trabucchi, P. F. Spano

Research output: Contribution to journalArticlepeer-review

Abstract

(3H)-haloperidol and (3H)-spiroperidol binding studies after kainate injection into the striatum indicate the presence of dopamine receptive sites not located on post-synaptic membranes. The majority of these dopamine "receptors" which are not associated to an adenylate cyclase appear to be localized on terminals of cortico-striatal neurons. On the other hand sulpiride, an antipsychotic drug which increases striatal dopamine synthesis, does not inhibit dopamine-stimulated adenylate cyclase either in vitro or in vivo. However sulpiride stereospecifically displaces (3H)-haloperidol from striatal binding sites.

Original languageEnglish
Pages (from-to)1745-1750
Number of pages6
JournalLife Sciences
Volume23
Issue number17-18
DOIs
Publication statusPublished - Oct 30 1978

ASJC Scopus subject areas

  • Pharmacology

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