Dopamine receptors

Pharmacological and anatomical evidences indicate that two distinct dopamine receptor populations are present in rat striatum

L. Garau, S. Govoni, E. Stefanini, M. Trabucchi, P. F. Spano

Research output: Contribution to journalArticle

136 Citations (Scopus)

Abstract

(3H)-haloperidol and (3H)-spiroperidol binding studies after kainate injection into the striatum indicate the presence of dopamine receptive sites not located on post-synaptic membranes. The majority of these dopamine "receptors" which are not associated to an adenylate cyclase appear to be localized on terminals of cortico-striatal neurons. On the other hand sulpiride, an antipsychotic drug which increases striatal dopamine synthesis, does not inhibit dopamine-stimulated adenylate cyclase either in vitro or in vivo. However sulpiride stereospecifically displaces (3H)-haloperidol from striatal binding sites.

Original languageEnglish
Pages (from-to)1745-1750
Number of pages6
JournalLife Sciences
Volume23
Issue number17-18
DOIs
Publication statusPublished - Oct 30 1978

Fingerprint

Corpus Striatum
Dopamine Receptors
Rats
Dopamine
Sulpiride
Pharmacology
Haloperidol
Adenylyl Cyclases
Population
Spiperone
Synaptic Membranes
Kainic Acid
Antipsychotic Agents
Neurons
Binding Sites
Membranes
Injections

ASJC Scopus subject areas

  • Pharmacology

Cite this

Dopamine receptors : Pharmacological and anatomical evidences indicate that two distinct dopamine receptor populations are present in rat striatum. / Garau, L.; Govoni, S.; Stefanini, E.; Trabucchi, M.; Spano, P. F.

In: Life Sciences, Vol. 23, No. 17-18, 30.10.1978, p. 1745-1750.

Research output: Contribution to journalArticle

Garau, L. ; Govoni, S. ; Stefanini, E. ; Trabucchi, M. ; Spano, P. F. / Dopamine receptors : Pharmacological and anatomical evidences indicate that two distinct dopamine receptor populations are present in rat striatum. In: Life Sciences. 1978 ; Vol. 23, No. 17-18. pp. 1745-1750.
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