Dopamine stimulation via infusion in the lateral ventricle

Francesca Biagioni, Carla L. Busceti, Gemma Molinaro, Giuseppe Battaglia, Filippo S. Giorgi, Stefano Ruggieri, Francesco Fornai

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Continuous dopamine (DA) stimulation is a therapeutic approach that applies to the treatment of motor fluctuations due to pulsatile DA stimulation in Parkinson's disease (PD), to cure the abuse of drugs, such as cocaine or amphetamine (which produce short-lasting peaks of extracellular DA), and as a safe therapeutic approach to avoid hedonistic homeostatic dysregulation (which sometime develops as an abuse pattern in PD patients receiving a pulsatile DA replacement therapy). However, systemic continuous delivery of DA agonists leads to a variety of side effects. In search for an alterative approach, in the present study we evaluated the possibility of delivering intracerebroventricularly (i.c.v.), a DA agonist: lisuride that was already shown to be effective when administered continuously subcutaneously (s.c.). In particular, we were interested in examining whether lisuride infused within the lateral ventricle was still able to stimulate DA receptor by inducing contralateral turning behavior in hemiparkinsonian rats. We found that lisuride, when infused in the lateral ventricle was effective in reducing the threshold for stimulating DA receptors. These results offer a more reliable and safe therapeutic approach to deliver continuous DA selectively in the brain.

Original languageEnglish
Title of host publicationAnnals of the New York Academy of Sciences
Pages337-343
Number of pages7
Volume1074
DOIs
Publication statusPublished - Aug 2006

Publication series

NameAnnals of the New York Academy of Sciences
Volume1074
ISSN (Print)00778923
ISSN (Electronic)17496632

Keywords

  • Amphetamines
  • Cocaine
  • Dopamine stimulation
  • Dyskinesia
  • Hedonistic homeostatic dysregulation
  • Intracerebroventricular
  • Lisuride
  • Parkinson's disease

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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