Dopamine transporter immunoreactivity in peripheral blood lymphocytes in multiple system atrophy

Francesca R. Buttarelli, Annapia Circella, Clelia Pellicano, Dorina Tiple, Morena Giovannelli, Carlo Colosimo, Francesco E. Pontieri

Research output: Contribution to journalArticle

Abstract

Previous studies showed the reduction of dopamine transporter immunoreactivity (DAT-IR) in peripheral blood lymphocytes (PBL) in Parkinson's disease. Here we report the reduction of DAT-IR in PBL in the extrapyramidal variant of multiple system atrophy. These results suggest the reduction of DAT-IR in PBL in a variety of neurodegenerative disorders, provided the presence of damage of the central dopaminergic systems. The reduction of DAT-IR in PBL in these disorders may represent a compensatory phenomenon aimed at reducing intracellular dopamine influx and, consequently, dopamine-mediated aggravation of oxidative stress in these cells.

Original languageEnglish
Pages (from-to)161-165
Number of pages5
JournalJournal of Neural Transmission
Volume116
Issue number2
DOIs
Publication statusPublished - Feb 2009

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Keywords

  • Dopamine transporter
  • Immunocytochemistry
  • Multiple system atrophy
  • Peripheral blood lymphocytes

ASJC Scopus subject areas

  • Clinical Neurology
  • Psychiatry and Mental health
  • Biological Psychiatry
  • Neurology

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