Dopamine transporter immunoreactivity in peripheral blood lymphocytes discriminates Parkinson's disease from essential tremor

C. Pellicano, F. R. Buttarelli, A. Circella, D. Tiple, M. Giovannelli, D. Benincasa, C. Colosimo, F. E. Pontieri

Research output: Contribution to journalArticlepeer-review

Abstract

Peripheral blood lymphocytes (PBL) provide a model to study the changes of neurotransmitter-receptor systems in neurodegenerative disorders, including Parkinson's disease (PD). In this study, densitometric analysis was applied to measure dopamine transporter (DAT) immunoreactivity in PBL from dopaminergic drug-free patients suffering PD or essential tremor (ET) with respect to healthy subjects. The results showed a significant reduction of DAT immunoreactivity in PBL in PD but not in ET. These finding suggests that DAT immunoreactivity in PBL may discriminate between PD and ET in the early clinical stages.

Original languageEnglish
Pages (from-to)935-938
Number of pages4
JournalJournal of Neural Transmission
Volume114
Issue number7
DOIs
Publication statusPublished - Jul 2007

Keywords

  • Dopamine transporter
  • Essential tremor
  • Lymphocytes
  • Parkinson's disease

ASJC Scopus subject areas

  • Neuroscience(all)

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