Dopamine uptake is differentially regulated in rat striatum and nucleus accumbens

C. Missale, L. Castelletti, S. Govoni, P. F. Spano, M. Trabucchi, I. Hanbauer

Research output: Contribution to journalArticle

120 Citations (Scopus)

Abstract

Active uptake of 3,4-dihydroxyphenylethylamine (dopamine) is sodium- and temperature-dependent, strongly inhibited by benztropine and nomifensine, and present in corpus striatum and nucleus accumbens. In rat striatum dopamine uptake is related to a receptor that is specifically labelled by [3H]cocaine in the presence of Na+ and is located on dopaminergic terminals. The dopamine uptake is differentially affected in the two areas by single or repeated injections of cocaine. Cocaine inhibits dopamine uptake in slices of corpus striatum. Moreover Na+-dependent [3H]cocaine binding is not detectable in nucleus accumbens. Nomifensine inhibits [3H]dopamine uptake by interacting with low- and high-affinity sites in corpus striatum, but shows only low affinity for dopamine uptake in nucleus accumbens. The present data indicate that different mechanisms are involved in the regulation of dopamine uptake in corpus striatum and nucleus accumbens.

Original languageEnglish
Pages (from-to)51-56
Number of pages6
JournalJournal of Neurochemistry
Volume45
Issue number1
DOIs
Publication statusPublished - 1985

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Corpus Striatum
Nucleus Accumbens
Cocaine
Rats
Dopamine
Nomifensine
Benztropine
Sodium
Injections
Temperature

ASJC Scopus subject areas

  • Biochemistry
  • Cellular and Molecular Neuroscience

Cite this

Missale, C., Castelletti, L., Govoni, S., Spano, P. F., Trabucchi, M., & Hanbauer, I. (1985). Dopamine uptake is differentially regulated in rat striatum and nucleus accumbens. Journal of Neurochemistry, 45(1), 51-56. https://doi.org/10.1111/j.1471-4159.1985.tb05473.x

Dopamine uptake is differentially regulated in rat striatum and nucleus accumbens. / Missale, C.; Castelletti, L.; Govoni, S.; Spano, P. F.; Trabucchi, M.; Hanbauer, I.

In: Journal of Neurochemistry, Vol. 45, No. 1, 1985, p. 51-56.

Research output: Contribution to journalArticle

Missale, C, Castelletti, L, Govoni, S, Spano, PF, Trabucchi, M & Hanbauer, I 1985, 'Dopamine uptake is differentially regulated in rat striatum and nucleus accumbens', Journal of Neurochemistry, vol. 45, no. 1, pp. 51-56. https://doi.org/10.1111/j.1471-4159.1985.tb05473.x
Missale, C. ; Castelletti, L. ; Govoni, S. ; Spano, P. F. ; Trabucchi, M. ; Hanbauer, I. / Dopamine uptake is differentially regulated in rat striatum and nucleus accumbens. In: Journal of Neurochemistry. 1985 ; Vol. 45, No. 1. pp. 51-56.
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