Dopaminergic agonists and l-dopa

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

L-DOPA and dopaminergic agonists represent the pharmacological options more commonly utilized for treating the symptoms of Parkinson's disease (PD). These drugs are able to improve motor disturbances related to loss of nigral dopaminergic neurons. L-DOPA predominantly improves bradykinesia and rigidity, maintaining its efficacy throughout the course of PD, although in advanced disease stages, it determines the appearance of motor fluctuations. Dopaminergic agonists are also effective when used alone, but their utilization is regularly recommended in combination with L-DOPA. They have a good effect on resting tremor. In addition, L-DOPA is dramatically effective in a primary form of generalized dystonia (levodopa sensitive). Moreover, low doses of dopaminergic agonists attenuate the symptomatologic cohort of the restless leg syndrome.

Original languageEnglish
Title of host publicationEncyclopedia of Neuroscience
PublisherElsevier Ltd
Pages601-607
Number of pages7
ISBN (Print)9780080450469
DOIs
Publication statusPublished - 2010

Keywords

  • 'On-off' phenomenon
  • Dopamine
  • Dopamine receptor agonists
  • Dopaminergic receptor
  • Dyskinesia
  • Dystonia
  • Ergoline derivatives
  • Motor fluctuations
  • Non-ergoline derivatives
  • Parkinson's disease
  • Pulsatile and continuous receptor stimulation
  • Restless leg syndrome

ASJC Scopus subject areas

  • Neuroscience(all)

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