Dopaminergic control of synaptic plasticity in the dorsal striatum

Diego Centonze, Barbara Picconi, Paolo Gubellini, Giorgio Bernardi, Paolo Calabresi

Research output: Contribution to journalArticle

Abstract

Cortical glutamatergic and nigral dopaminergic afferents impinge on projection spiny neurons of the striatum, providing the most significant inputs to this structure. Isolated activation of glutamate or dopamine (DA) receptors produces short-term effects on striatal neurons, whereas the combined stimulation of both glutamate and DA receptors is able to induce long-lasting modifications of synaptic excitability. Repetitive stimulation of corticostriatal fibres causes a massive release of both glutamate and DA in the striatum and, depending on the glutamate receptor subtype preferentially activated, produces either long-term depression (LTD) or long-term potentiation (LTP) of excitatory synaptic transmission. D1-like and D2-like DA receptors interact synergistically to allow LTD formation, while they operate in opposition during the induction phase of LTP. Corticostriatal synaptic plasticity is severely impaired after chronic DA denervation and requires the stimulation of DARPP-32, a small protein expressed in dopaminoceptive spiny neurons which acts as a potent inhibitor of protein phosphatase-1. In addition, the formation of LTD and LTP requires the activation of PKG and PKA, respectively, in striatal projection neurons. These kinases appear to be stimulated by the activation of D1-like receptors in distinct neuronal populations.

Original languageEnglish
Pages (from-to)1071-1077
Number of pages7
JournalEuropean Journal of Neuroscience
Volume13
Issue number6
DOIs
Publication statusPublished - 2001

Fingerprint

Neuronal Plasticity
Long-Term Potentiation
Glutamate Receptors
Neurons
Corpus Striatum
Dopamine Receptors
Dopamine
Dopamine D2 Receptors
Denervation
Substantia Nigra
Synaptic Transmission
Glutamic Acid
Phosphotransferases
Population
Proteins

Keywords

  • D1 dopamine receptors
  • D2 dopamine receptors
  • Long-term depression
  • Long-term potentiation
  • Parkinson's disease
  • Protein kinase A

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Dopaminergic control of synaptic plasticity in the dorsal striatum. / Centonze, Diego; Picconi, Barbara; Gubellini, Paolo; Bernardi, Giorgio; Calabresi, Paolo.

In: European Journal of Neuroscience, Vol. 13, No. 6, 2001, p. 1071-1077.

Research output: Contribution to journalArticle

@article{146a8e2c17b5405293609f604c68a6b1,
title = "Dopaminergic control of synaptic plasticity in the dorsal striatum",
abstract = "Cortical glutamatergic and nigral dopaminergic afferents impinge on projection spiny neurons of the striatum, providing the most significant inputs to this structure. Isolated activation of glutamate or dopamine (DA) receptors produces short-term effects on striatal neurons, whereas the combined stimulation of both glutamate and DA receptors is able to induce long-lasting modifications of synaptic excitability. Repetitive stimulation of corticostriatal fibres causes a massive release of both glutamate and DA in the striatum and, depending on the glutamate receptor subtype preferentially activated, produces either long-term depression (LTD) or long-term potentiation (LTP) of excitatory synaptic transmission. D1-like and D2-like DA receptors interact synergistically to allow LTD formation, while they operate in opposition during the induction phase of LTP. Corticostriatal synaptic plasticity is severely impaired after chronic DA denervation and requires the stimulation of DARPP-32, a small protein expressed in dopaminoceptive spiny neurons which acts as a potent inhibitor of protein phosphatase-1. In addition, the formation of LTD and LTP requires the activation of PKG and PKA, respectively, in striatal projection neurons. These kinases appear to be stimulated by the activation of D1-like receptors in distinct neuronal populations.",
keywords = "D1 dopamine receptors, D2 dopamine receptors, Long-term depression, Long-term potentiation, Parkinson's disease, Protein kinase A",
author = "Diego Centonze and Barbara Picconi and Paolo Gubellini and Giorgio Bernardi and Paolo Calabresi",
year = "2001",
doi = "10.1046/j.0953-816X.2001.01485.x",
language = "English",
volume = "13",
pages = "1071--1077",
journal = "European Journal of Neuroscience",
issn = "0953-816X",
publisher = "Wiley-Blackwell",
number = "6",

}

TY - JOUR

T1 - Dopaminergic control of synaptic plasticity in the dorsal striatum

AU - Centonze, Diego

AU - Picconi, Barbara

AU - Gubellini, Paolo

AU - Bernardi, Giorgio

AU - Calabresi, Paolo

PY - 2001

Y1 - 2001

N2 - Cortical glutamatergic and nigral dopaminergic afferents impinge on projection spiny neurons of the striatum, providing the most significant inputs to this structure. Isolated activation of glutamate or dopamine (DA) receptors produces short-term effects on striatal neurons, whereas the combined stimulation of both glutamate and DA receptors is able to induce long-lasting modifications of synaptic excitability. Repetitive stimulation of corticostriatal fibres causes a massive release of both glutamate and DA in the striatum and, depending on the glutamate receptor subtype preferentially activated, produces either long-term depression (LTD) or long-term potentiation (LTP) of excitatory synaptic transmission. D1-like and D2-like DA receptors interact synergistically to allow LTD formation, while they operate in opposition during the induction phase of LTP. Corticostriatal synaptic plasticity is severely impaired after chronic DA denervation and requires the stimulation of DARPP-32, a small protein expressed in dopaminoceptive spiny neurons which acts as a potent inhibitor of protein phosphatase-1. In addition, the formation of LTD and LTP requires the activation of PKG and PKA, respectively, in striatal projection neurons. These kinases appear to be stimulated by the activation of D1-like receptors in distinct neuronal populations.

AB - Cortical glutamatergic and nigral dopaminergic afferents impinge on projection spiny neurons of the striatum, providing the most significant inputs to this structure. Isolated activation of glutamate or dopamine (DA) receptors produces short-term effects on striatal neurons, whereas the combined stimulation of both glutamate and DA receptors is able to induce long-lasting modifications of synaptic excitability. Repetitive stimulation of corticostriatal fibres causes a massive release of both glutamate and DA in the striatum and, depending on the glutamate receptor subtype preferentially activated, produces either long-term depression (LTD) or long-term potentiation (LTP) of excitatory synaptic transmission. D1-like and D2-like DA receptors interact synergistically to allow LTD formation, while they operate in opposition during the induction phase of LTP. Corticostriatal synaptic plasticity is severely impaired after chronic DA denervation and requires the stimulation of DARPP-32, a small protein expressed in dopaminoceptive spiny neurons which acts as a potent inhibitor of protein phosphatase-1. In addition, the formation of LTD and LTP requires the activation of PKG and PKA, respectively, in striatal projection neurons. These kinases appear to be stimulated by the activation of D1-like receptors in distinct neuronal populations.

KW - D1 dopamine receptors

KW - D2 dopamine receptors

KW - Long-term depression

KW - Long-term potentiation

KW - Parkinson's disease

KW - Protein kinase A

UR - http://www.scopus.com/inward/record.url?scp=0035060448&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0035060448&partnerID=8YFLogxK

U2 - 10.1046/j.0953-816X.2001.01485.x

DO - 10.1046/j.0953-816X.2001.01485.x

M3 - Article

C2 - 11285003

AN - SCOPUS:0035060448

VL - 13

SP - 1071

EP - 1077

JO - European Journal of Neuroscience

JF - European Journal of Neuroscience

SN - 0953-816X

IS - 6

ER -