Dopaminergic D2 receptor activation modulates FGF-2 gene expression in rat prefrontal cortex and hippocampus

Fabio Fumagalli, Francesco Bedogni, Maria Elisabetta Maragnoli, Massimo Gennarelli, Jorge Perez, Giorgio Racagni, Marco Andrea Riva

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

We have investigated the role of dopaminergic receptors in modulation of basic fibroblast growth factor (FGF-2) expression in rat prefrontal cortex and hippocampus, two brain regions important for cognition. We found that FGF-2 expression is upregulated by quinpirole, a D2 agonist, in prefrontal cortex and to a lesser extent in hippocampus. This modulation was specific for dopamine D2 receptors because no effect was observed when the dopamine D1 and D3 agonists, SKF38393 and 7-OH-DPAT, respectively, were administered. Our findings show that activation of dopaminergic D2 receptors modulates FGF-2 expression in rat prefrontal cortex and hippocampus. Our data highlight the complex modulation of FGF-2 expression in limbic areas pointing to this trophic molecule as a putative target of drugs used against acute and chronic neurodegenerative diseases such as Parkinson's disease.

Original languageEnglish
Pages (from-to)74-80
Number of pages7
JournalJournal of Neuroscience Research
Volume74
Issue number1
DOIs
Publication statusPublished - Oct 1 2003

Fingerprint

Fibroblast Growth Factor 2
Prefrontal Cortex
Hippocampus
Gene Expression
2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine
Quinpirole
Dopamine D2 Receptors
Neurodegenerative Diseases
Cognition
Parkinson Disease
Dopamine
Chronic Disease
Brain
Pharmaceutical Preparations

Keywords

  • Neuroplasticity
  • Neurotrophic factors
  • Quinpirole

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Dopaminergic D2 receptor activation modulates FGF-2 gene expression in rat prefrontal cortex and hippocampus. / Fumagalli, Fabio; Bedogni, Francesco; Maragnoli, Maria Elisabetta; Gennarelli, Massimo; Perez, Jorge; Racagni, Giorgio; Riva, Marco Andrea.

In: Journal of Neuroscience Research, Vol. 74, No. 1, 01.10.2003, p. 74-80.

Research output: Contribution to journalArticle

Fumagalli, Fabio ; Bedogni, Francesco ; Maragnoli, Maria Elisabetta ; Gennarelli, Massimo ; Perez, Jorge ; Racagni, Giorgio ; Riva, Marco Andrea. / Dopaminergic D2 receptor activation modulates FGF-2 gene expression in rat prefrontal cortex and hippocampus. In: Journal of Neuroscience Research. 2003 ; Vol. 74, No. 1. pp. 74-80.
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