Dopaminergic drug-induced modulation of the expression of the dopamine transporter in peripheral blood lymphocytes in Parkinson's disease

Alessandra Fanciulli, Roberta Misasi, Dario Campanelli, Francesca R. Buttarelli, Francesco E. Pontieri

Research output: Contribution to journalArticlepeer-review

Abstract

The modulation of expression of the dopamine transporter by dopaminergic drugs was investigated by flow cytometry in peripheral blood lymphocytes from patients suffering Parkinson's disease. An 8-week in vivo exposure to pramipexole (0.7 mg free base, 3 times a day) or ropinirole (12 mg, once daily), but not levodopa/carbidopa (100/25 mg, 3 times a day), significantly reduced the mean fluorescence intensity of the dopamine transporter in peripheral blood lymphocytes. These results demonstrate that levodopa differs from dopamine agonists in its regulation of dopamine transporter expression in peripheral blood lymphocytes.

Original languageEnglish
Pages (from-to)1056-1060
Number of pages5
JournalPharmacological Reports
Volume63
Issue number4
Publication statusPublished - 2011

Keywords

  • Dopamine transporter
  • Levodopa
  • Parkinson's disease
  • Peripheral blood lymphocytes
  • Pramipexole
  • Ropinirole

ASJC Scopus subject areas

  • Pharmacology

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