Dopaminergic Neuronal Imaging in Genetic Parkinson's Disease

Insights into Pathogenesis

Alisdair McNeill, Ruey Meei Wu, Kai Yuan Tzen, Patricia C. Aguiar, Jose M. Arbelo, Paolo Barone, Kailash Bhatia, Orlando Barsottini, Vincenzo Bonifati, Sevasti Bostantjopoulou, Rodrigo Bressan, Giovanni Cossu, Pietro Cortelli, Andre Felicio, Henrique B. Ferraz, Joanna Herrera, Henry Houlden, Marcelo Hoexter, Concepcion Isla, Andrew Lees & 9 others Oswaldo Lorenzo-Betancor, Niccolo E. Mencacci, Pau Pastor, Sabina Pappata, Maria Teresa Pellecchia, Laura Silveria-Moriyama, Andrea Varrone, Tom Foltynie, Anthony H V Schapira

Research output: Contribution to journalArticle

36 Citations (Scopus)

Abstract

Objectives:To compare the dopaminergic neuronal imaging features of different subtypes of genetic Parkinson's Disease.Methods:A retrospective study of genetic Parkinson's diseases cases in which DaTSCAN (123I-FP-CIT) had been performed. Specific non-displaceable binding was calculated for bilateral caudate and putamen for each case. The right:left asymmetry index and striatal asymmetry index was calculated.Results:Scans were available from 37 cases of monogenetic Parkinson's disease (7 glucocerebrosidase (GBA) mutations, 8 alpha-synuclein, 3 LRRK2, 7 PINK1, 12 Parkin). The asymmetry of radioligand uptake for Parkinson's disease with GBA or LRRK2 mutations was greater than that for Parkinson's disease with alpha synuclein, PINK1 or Parkin mutations.Conclusions:The asymmetry of radioligand uptake in Parkinsons disease associated with GBA or LRRK2 mutations suggests that interactions with additional genetic or environmental factors may be associated with dopaminergic neuronal loss.

Original languageEnglish
Article numbere69190
JournalPLoS One
Volume8
Issue number7
DOIs
Publication statusPublished - Jul 23 2013

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Inborn Genetic Diseases
Parkinson disease
Parkinson Disease
pathogenesis
image analysis
Glucosylceramidase
Imaging techniques
mutation
alpha-Synuclein
Mutation
Corpus Striatum
Putamen
retrospective studies
Retrospective Studies
environmental factors

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

McNeill, A., Wu, R. M., Tzen, K. Y., Aguiar, P. C., Arbelo, J. M., Barone, P., ... Schapira, A. H. V. (2013). Dopaminergic Neuronal Imaging in Genetic Parkinson's Disease: Insights into Pathogenesis. PLoS One, 8(7), [e69190]. https://doi.org/10.1371/journal.pone.0069190

Dopaminergic Neuronal Imaging in Genetic Parkinson's Disease : Insights into Pathogenesis. / McNeill, Alisdair; Wu, Ruey Meei; Tzen, Kai Yuan; Aguiar, Patricia C.; Arbelo, Jose M.; Barone, Paolo; Bhatia, Kailash; Barsottini, Orlando; Bonifati, Vincenzo; Bostantjopoulou, Sevasti; Bressan, Rodrigo; Cossu, Giovanni; Cortelli, Pietro; Felicio, Andre; Ferraz, Henrique B.; Herrera, Joanna; Houlden, Henry; Hoexter, Marcelo; Isla, Concepcion; Lees, Andrew; Lorenzo-Betancor, Oswaldo; Mencacci, Niccolo E.; Pastor, Pau; Pappata, Sabina; Pellecchia, Maria Teresa; Silveria-Moriyama, Laura; Varrone, Andrea; Foltynie, Tom; Schapira, Anthony H V.

In: PLoS One, Vol. 8, No. 7, e69190, 23.07.2013.

Research output: Contribution to journalArticle

McNeill, A, Wu, RM, Tzen, KY, Aguiar, PC, Arbelo, JM, Barone, P, Bhatia, K, Barsottini, O, Bonifati, V, Bostantjopoulou, S, Bressan, R, Cossu, G, Cortelli, P, Felicio, A, Ferraz, HB, Herrera, J, Houlden, H, Hoexter, M, Isla, C, Lees, A, Lorenzo-Betancor, O, Mencacci, NE, Pastor, P, Pappata, S, Pellecchia, MT, Silveria-Moriyama, L, Varrone, A, Foltynie, T & Schapira, AHV 2013, 'Dopaminergic Neuronal Imaging in Genetic Parkinson's Disease: Insights into Pathogenesis', PLoS One, vol. 8, no. 7, e69190. https://doi.org/10.1371/journal.pone.0069190
McNeill A, Wu RM, Tzen KY, Aguiar PC, Arbelo JM, Barone P et al. Dopaminergic Neuronal Imaging in Genetic Parkinson's Disease: Insights into Pathogenesis. PLoS One. 2013 Jul 23;8(7). e69190. https://doi.org/10.1371/journal.pone.0069190
McNeill, Alisdair ; Wu, Ruey Meei ; Tzen, Kai Yuan ; Aguiar, Patricia C. ; Arbelo, Jose M. ; Barone, Paolo ; Bhatia, Kailash ; Barsottini, Orlando ; Bonifati, Vincenzo ; Bostantjopoulou, Sevasti ; Bressan, Rodrigo ; Cossu, Giovanni ; Cortelli, Pietro ; Felicio, Andre ; Ferraz, Henrique B. ; Herrera, Joanna ; Houlden, Henry ; Hoexter, Marcelo ; Isla, Concepcion ; Lees, Andrew ; Lorenzo-Betancor, Oswaldo ; Mencacci, Niccolo E. ; Pastor, Pau ; Pappata, Sabina ; Pellecchia, Maria Teresa ; Silveria-Moriyama, Laura ; Varrone, Andrea ; Foltynie, Tom ; Schapira, Anthony H V. / Dopaminergic Neuronal Imaging in Genetic Parkinson's Disease : Insights into Pathogenesis. In: PLoS One. 2013 ; Vol. 8, No. 7.
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AU - Arbelo, Jose M.

AU - Barone, Paolo

AU - Bhatia, Kailash

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