Dopaminergic receptor D5 mRNA expression is increased in circulating lymphocytes of Tourette syndrome patients

Marco Ferrari; Cristiano Termine; Diego Franciotta; Elisabetta Castiglioni; Alessandra Pagani; Giovanni Lanzi; Franca Marino; Sergio Lecchini; Marco Cosentino; Umberto Balottin

doi:10.1016/j.jpsychires.2008.01.014

Dopaminergic receptor D5 mRNA expression is increased in circulating lymphocytes of Tourette syndrome patients

Marco Ferrari, Cristiano Termine, Diego Franciotta, Elisabetta Castiglioni, Alessandra Pagani, Giovanni Lanzi, Franca Marino, Sergio Lecchini, Marco Cosentino, Umberto Balottin

Fondazione "Istituto Neurologico Casimiro Mondino"

Research output: Contribution to journal › Article › peer-review

Abstract

Tourette syndrome (TS) is a neuropsychiatric disorder in which dopaminergic dysfunction and immune system abnormalities seem to coexist. Using real-time PCR, we determined mRNA expression of dopamine receptors (DRs) D1-5 in peripheral blood lymphocytes (PBLs) from 15 TS patients and 15 sex- and age-matched healthy controls (HCs). DRD5 mRNA levels in cells from TS were higher than in cells from HCs. In TS patients with obsessive-compulsive disorder, DRD5 mRNA levels in PBLs showed a highly positive correlation with the severity of compulsive symptoms. DRD5 mRNA upregulation in PBLs from TS patients may represent a peripheral marker of dopaminergic dysfunction and supports the involvement of the immune system in TS.

Original language	English
Pages (from-to)	24-29
Number of pages	6
Journal	Journal of Psychiatric Research
Volume	43
Issue number	1
DOIs	https://doi.org/10.1016/j.jpsychires.2008.01.014
Publication status	Published - Nov 2008

Keywords

Dopamine receptors
Peripheral blood lymphocytes
Peripheral marker
Real-time PCR
Tourette syndrome

ASJC Scopus subject areas

Psychiatry and Mental health
Biological Psychiatry

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10.1016/j.jpsychires.2008.01.014

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Dopaminergic receptor D5 mRNA expression is increased in circulating lymphocytes of Tourette syndrome patients. / Ferrari, Marco; Termine, Cristiano; Franciotta, Diego; Castiglioni, Elisabetta; Pagani, Alessandra; Lanzi, Giovanni; Marino, Franca; Lecchini, Sergio; Cosentino, Marco; Balottin, Umberto.

In: Journal of Psychiatric Research, Vol. 43, No. 1, 11.2008, p. 24-29.

Research output: Contribution to journal › Article › peer-review

Ferrari, Marco ; Termine, Cristiano ; Franciotta, Diego ; Castiglioni, Elisabetta ; Pagani, Alessandra ; Lanzi, Giovanni ; Marino, Franca ; Lecchini, Sergio ; Cosentino, Marco ; Balottin, Umberto. / Dopaminergic receptor D5 mRNA expression is increased in circulating lymphocytes of Tourette syndrome patients. In: Journal of Psychiatric Research. 2008 ; Vol. 43, No. 1. pp. 24-29.

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abstract = "Tourette syndrome (TS) is a neuropsychiatric disorder in which dopaminergic dysfunction and immune system abnormalities seem to coexist. Using real-time PCR, we determined mRNA expression of dopamine receptors (DRs) D1-5 in peripheral blood lymphocytes (PBLs) from 15 TS patients and 15 sex- and age-matched healthy controls (HCs). DRD5 mRNA levels in cells from TS were higher than in cells from HCs. In TS patients with obsessive-compulsive disorder, DRD5 mRNA levels in PBLs showed a highly positive correlation with the severity of compulsive symptoms. DRD5 mRNA upregulation in PBLs from TS patients may represent a peripheral marker of dopaminergic dysfunction and supports the involvement of the immune system in TS.",

keywords = "Dopamine receptors, Peripheral blood lymphocytes, Peripheral marker, Real-time PCR, Tourette syndrome",

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AU - Ferrari, Marco

AU - Termine, Cristiano

AU - Franciotta, Diego

AU - Castiglioni, Elisabetta

AU - Pagani, Alessandra

AU - Lanzi, Giovanni

AU - Marino, Franca

AU - Lecchini, Sergio

AU - Cosentino, Marco

AU - Balottin, Umberto

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AB - Tourette syndrome (TS) is a neuropsychiatric disorder in which dopaminergic dysfunction and immune system abnormalities seem to coexist. Using real-time PCR, we determined mRNA expression of dopamine receptors (DRs) D1-5 in peripheral blood lymphocytes (PBLs) from 15 TS patients and 15 sex- and age-matched healthy controls (HCs). DRD5 mRNA levels in cells from TS were higher than in cells from HCs. In TS patients with obsessive-compulsive disorder, DRD5 mRNA levels in PBLs showed a highly positive correlation with the severity of compulsive symptoms. DRD5 mRNA upregulation in PBLs from TS patients may represent a peripheral marker of dopaminergic dysfunction and supports the involvement of the immune system in TS.

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KW - Peripheral marker

KW - Real-time PCR

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