Dopaminergic receptor D5 mRNA expression is increased in circulating lymphocytes of Tourette syndrome patients

Marco Ferrari, Cristiano Termine, Diego Franciotta, Elisabetta Castiglioni, Alessandra Pagani, Giovanni Lanzi, Franca Marino, Sergio Lecchini, Marco Cosentino, Umberto Balottin

Research output: Contribution to journalArticle

Abstract

Tourette syndrome (TS) is a neuropsychiatric disorder in which dopaminergic dysfunction and immune system abnormalities seem to coexist. Using real-time PCR, we determined mRNA expression of dopamine receptors (DRs) D1-5 in peripheral blood lymphocytes (PBLs) from 15 TS patients and 15 sex- and age-matched healthy controls (HCs). DRD5 mRNA levels in cells from TS were higher than in cells from HCs. In TS patients with obsessive-compulsive disorder, DRD5 mRNA levels in PBLs showed a highly positive correlation with the severity of compulsive symptoms. DRD5 mRNA upregulation in PBLs from TS patients may represent a peripheral marker of dopaminergic dysfunction and supports the involvement of the immune system in TS.

Original languageEnglish
Pages (from-to)24-29
Number of pages6
JournalJournal of Psychiatric Research
Volume43
Issue number1
DOIs
Publication statusPublished - Nov 2008

Keywords

  • Dopamine receptors
  • Peripheral blood lymphocytes
  • Peripheral marker
  • Real-time PCR
  • Tourette syndrome

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry

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