Dopaminergic receptor mechanisms modulating the renin-angiotensin system and aldosterone secretion: An overview

Cristina Missale, Carlo Lombardi, Roberto De Cotiis, Maurizio Memo, Michele O. Carruba, Pier Franco Spano

Research output: Contribution to journalArticle

46 Citations (Scopus)

Abstract

Several studies suggested that dopamine may be one of the inhibitory modulators of aldosterone secretion. Metoclopramide. a selective antagonist for dopa-mine D-2 receptors, increases both basai plasma aldosterone levels and the aldosterone response to angiotensin II (Ang II) in rats and humans kept on a high sodium intake. these effects being blocked by dopamine infusion. Dopamine, which has no significant effects on Ang II-induced aldosterone secretion in sodium-replete subjects, inhibits the hormonal response to Ang II infusion in sodiumdepleted normal subjects. suggesting that the sodium balance state may be an important factor in the dopaminergic mechanisms controlling aldosterone secretion. The effect of dopamine on the hormone production is mediated by D-2 receptors in the adrenal cortex as shown by in vitro studies with isolated adrenal glome-rulosa cells. Clinical studies have shown that dihydroer-gotoxine, a selective D-2 agonist, suppresses the aldosterone secretion induced by sodium depletion in hypertensive patients, an effect blocked by sulpiride. This mechanism could be of relevant therapeutic interest in its contribution to the natriuretic effects of dopaminergic agonists, which have clinical applications in the treatment of hypertension and congestive heart failure.

Original languageEnglish
Pages (from-to)S29-S39
JournalJournal of Cardiovascular Pharmacology
Volume14
Publication statusPublished - 1989

Fingerprint

Renin-Angiotensin System
Aldosterone
Dopamine
Sodium
Angiotensin II
Natriuretic Agents
Sulpiride
Dihydroxyphenylalanine
Metoclopramide
Adrenal Cortex
Dopamine Agonists
Heart Failure
Hormones
Hypertension
Therapeutics

Keywords

  • Aldosterone
  • Angiotensin II
  • D-2 receptors
  • Dopamine

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Pharmacology

Cite this

Missale, C., Lombardi, C., De Cotiis, R., Memo, M., Carruba, M. O., & Spano, P. F. (1989). Dopaminergic receptor mechanisms modulating the renin-angiotensin system and aldosterone secretion: An overview. Journal of Cardiovascular Pharmacology, 14, S29-S39.

Dopaminergic receptor mechanisms modulating the renin-angiotensin system and aldosterone secretion : An overview. / Missale, Cristina; Lombardi, Carlo; De Cotiis, Roberto; Memo, Maurizio; Carruba, Michele O.; Spano, Pier Franco.

In: Journal of Cardiovascular Pharmacology, Vol. 14, 1989, p. S29-S39.

Research output: Contribution to journalArticle

Missale, C, Lombardi, C, De Cotiis, R, Memo, M, Carruba, MO & Spano, PF 1989, 'Dopaminergic receptor mechanisms modulating the renin-angiotensin system and aldosterone secretion: An overview', Journal of Cardiovascular Pharmacology, vol. 14, pp. S29-S39.
Missale, Cristina ; Lombardi, Carlo ; De Cotiis, Roberto ; Memo, Maurizio ; Carruba, Michele O. ; Spano, Pier Franco. / Dopaminergic receptor mechanisms modulating the renin-angiotensin system and aldosterone secretion : An overview. In: Journal of Cardiovascular Pharmacology. 1989 ; Vol. 14. pp. S29-S39.
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