Dopaminergic striatal innervation predicts interlimb transfer of a visuomotor skill

Ioannis U. Isaias, Clara Moisello, Giorgio Marotta, Mauro Schiavella, Margherita Canesi, Bernardo Perfetti, Paolo Cavallari, Gianni Pezzoli, M. Felice Ghilardi

Research output: Contribution to journalArticlepeer-review


Weinvestigated whether dopamine influences the rate of adaptation to a visuomotor distortion and the transfer of this learning from the right to the left limb in human subjects. We thus studied patients with Parkinson disease as a putative in vivo model of dopaminergic denervation. Despite normal adaptation rates, patients showed a reduced transfer compared with age-matched healthy controls. The magnitude of the transfer, but not of the adaptation rate, was positively predicted by the values of dopamine-transporter binding of the right caudate and putamen. We conclude that striatal dopaminergic activity plays an important role in the transfer of visuomotor skills.

Original languageEnglish
Pages (from-to)14458-14462
Number of pages5
JournalJournal of Neuroscience
Issue number41
Publication statusPublished - Oct 12 2011

ASJC Scopus subject areas

  • Neuroscience(all)


Dive into the research topics of 'Dopaminergic striatal innervation predicts interlimb transfer of a visuomotor skill'. Together they form a unique fingerprint.

Cite this