Dopaminergic striatal innervation predicts interlimb transfer of a visuomotor skill

Ioannis U. Isaias, Clara Moisello, Giorgio Marotta, Mauro Schiavella, Margherita Canesi, Bernardo Perfetti, Paolo Cavallari, Gianni Pezzoli, M. Felice Ghilardi

Research output: Contribution to journalArticle

Abstract

Weinvestigated whether dopamine influences the rate of adaptation to a visuomotor distortion and the transfer of this learning from the right to the left limb in human subjects. We thus studied patients with Parkinson disease as a putative in vivo model of dopaminergic denervation. Despite normal adaptation rates, patients showed a reduced transfer compared with age-matched healthy controls. The magnitude of the transfer, but not of the adaptation rate, was positively predicted by the values of dopamine-transporter binding of the right caudate and putamen. We conclude that striatal dopaminergic activity plays an important role in the transfer of visuomotor skills.

Original languageEnglish
Pages (from-to)14458-14462
Number of pages5
JournalJournal of Neuroscience
Volume31
Issue number41
DOIs
Publication statusPublished - Oct 12 2011

ASJC Scopus subject areas

  • Neuroscience(all)

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    Isaias, I. U., Moisello, C., Marotta, G., Schiavella, M., Canesi, M., Perfetti, B., Cavallari, P., Pezzoli, G., & Ghilardi, M. F. (2011). Dopaminergic striatal innervation predicts interlimb transfer of a visuomotor skill. Journal of Neuroscience, 31(41), 14458-14462. https://doi.org/10.1523/JNEUROSCI.3583-11.2011