The authors report the case of a 15-year-old girl suffering from Lafora's disease, confirmed by skin biopsy performed according to the Carpenter-Karpati technique. Elementary partial seizures characterized the beginning of the disease, whereas generalized convulsive seizures and myoclonic jerks appeared later. Lastly, frequent epileptic states occurred. Since a dopaminergic mechanism seems to be involved in the pathophysiology of photosensitive epilepsy, bromocriptine and successively selegiline were added to the standard antiepileptic treatment. The dopaminergic agonist and the B-MAO inhibitor markedly reduced the seizure frequency, increasing vigilance and responsiveness. This effect was more evident during the treatment with both drugs.
|Translated title of the contribution||Dopaminergic treatment in a case of Lafora's disease|
|Number of pages||3|
|Journal||Bollettino - Lega Italiana contro l'Epilessia|
|Publication status||Published - 1986|
ASJC Scopus subject areas
- Clinical Neurology