Objective: The aim of the present study has been to determine the effects of the hormone replacement therapy (HRT) on Doppler flow parameters of the uterine artery and of the palmaris superficialis branch of the radial artery. Methods: Fourteen postmenopausal women (53.4 ± 2.9 years; Mean ± SD) participated in the study; they were given a continuous estradiol transdermal supplementation associated with medroxyprogesterone acetate (from 10th to 22th day, every two months). All patients were examined both before beginning the treatment and after six weeks of treatment. During the estrogen-only phase of the hormone replacement therapy all the women underwent transvaginal ultrasonographic evaluation of the pelvic organs and endometrial thickness. On the same day, patients underwent a colour Doppler analysis of the blood flow impedance of the uterine artery and of the palmaris superficialis branch of the radial artery. Results: After six weeks of transdermal HRT we observed, as far as both arteries were concerned, a significant reduction of the Pulsatility Index in comparison with the initial conditions. The mean decrease was -10 % for the uterine artery and -14 % for the palmaris superficialis branch of the radial artery. Conclusions: These results confirm the beneficial effects the hormone replacement therapy has on the vascular tone of the uterine artery. Furthermore, our findings suggest that the Doppler analysis of the palmaris superficialis branch of the radial artery is accurate and sensitive and may be useful to monitor the peripheral vascular effects of the HRT.
|Number of pages||6|
|Journal||Italian Journal of Gynaecology and Obstetrics|
|Publication status||Published - Jan 2003|
ASJC Scopus subject areas
- Obstetrics and Gynaecology