Doppler flow and echocardiography in functional cardiac insufficiency

Assessment of nisoldipine therapy. Results of the DEFIANT-II study

P. A. Poole-Wilson, P. Hanrath, N. Gerich, U. Flachskampf, B. De Bruyne, J. Bartunek, P. Goemaere, A. Carreras, A. Bayes de Luna, M. Schartl, W. Bocksch, D. Barkow, S. Beckmann, S. Dreysse, R. J C Hall, S. Ikram, A. Yapanis, H. Saunders, R. Seabra-Gomes, M. Mendes & 79 others L. Brizida, M. Canada, M. J. Andrade, A. Lauten, G. Oltmans, A. Lang, H. Schwela, J. Machecourt, B. Bertrand, B. S. Lewis, A. Merdler, D. A. Halon, T. Dagan, F. Dienstl, H. Hoertnagl, P. Lechleitner, R. Eiter, A. Keren, Z. Khoury, V. Gabay, A. Friart, Y. Devaleriola, C. Philippart, J. McLenachan, J. Smyllie, L. Engelmann, H. J. Duck, B. Krosse, H. Pankau, C. Ribeiro, R. Ferreira, M. J. Correira, F. Pais, A. Araujo, A. P. Monteiro, J. G. Azevedo, M. Melo, A. Bordalo, L. Botas, M. G. St John Sutton, G. Sutton, M. I M Noble, P. Stubbs, E. Ramhamadamay, X. Andre-Fouet, M. P. Mulin, R. Erbel, U. Nixdorff, J. E. Otterstad, G. Froeland, M. Previtali, A. Mussini, A Distante A, P. Fioretti, M. Motro, Z. Vered, M. S. Feinberg, J. Shemesh, P. Benjamin, N. Holwerda, P. Melman, M. Casaccia, W. Bottone, E. Bellone, A. De Bernadi, L. Hatle, K. Bjoernstad, S. Askhus, T. Hole, S. Samstad, J. Soma, P. Marino, P. Zardini, M. Anselmi, L. Rossi, L. Zanolla, G. P. Nidasio, B. Marchandise, E. Schroeder

Research output: Contribution to journalArticle

45 Citations (Scopus)

Abstract

Aims. A multicentre, double-blind, placebo-controlled trial was conducted in 542 patients, randomized 7-10 days after myocardial infarction, to study the effect of nisoldipine coat-core (nisoldipine-CC) on exercise after 6 months. Secondary endpoints included exercise-induced ischaemia, left ventricular function measured by Doppler echocardiography, adverse cardiac events and clinical outcome. Methods and results. Patients had reduced left ventricular ejection fraction between 25 and 50%, but no heart failure. Exercise time was not different in the two groups. Nisoldipine-CC prolonged time to 1 mm ST deviation (P = 003). There was an effect of nisoldipine-CC of +3.6 cm.s-1 early peak velocity (P = 0.01) and of - 6.2 ms on isovolumic relaxation time (P = 0.005), but no effects on left ventricular volumes or ejection fraction. There was a trend towards reduced mortality (one death in the nisoldipine-CC group vs seven in the placebo group, P <0.07) and the combined end-point of mortality and cardiac events (P = 0.09). Peripheral oedema occurred in 49 patients assigned to nisoldipine-CC and two assigned to placebo (P <0.001). There were no differences in non-cardiac events. Conclusions. Nisoldipine-CC did not improve exercise time but increased time to 1 mm ST deviation, and improved diastolic left ventricular function. It is safe and well tolerated in post-infarction patients with impaired left ventricular function.

Original languageEnglish
Pages (from-to)31-40
Number of pages10
JournalEuropean Heart Journal
Volume18
Issue number1
Publication statusPublished - 1997

Fingerprint

Nisoldipine
Doppler Echocardiography
Left Ventricular Function
Exercise
Placebos
Therapeutics
Mortality
Stroke Volume
Infarction
Edema
Ischemia
Heart Failure
Myocardial Infarction

Keywords

  • Bicycle ergometry
  • Calcium antagonist
  • Doppler echocardiography
  • Post-MI

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Poole-Wilson, P. A., Hanrath, P., Gerich, N., Flachskampf, U., De Bruyne, B., Bartunek, J., ... Schroeder, E. (1997). Doppler flow and echocardiography in functional cardiac insufficiency: Assessment of nisoldipine therapy. Results of the DEFIANT-II study. European Heart Journal, 18(1), 31-40.

Doppler flow and echocardiography in functional cardiac insufficiency : Assessment of nisoldipine therapy. Results of the DEFIANT-II study. / Poole-Wilson, P. A.; Hanrath, P.; Gerich, N.; Flachskampf, U.; De Bruyne, B.; Bartunek, J.; Goemaere, P.; Carreras, A.; Bayes de Luna, A.; Schartl, M.; Bocksch, W.; Barkow, D.; Beckmann, S.; Dreysse, S.; Hall, R. J C; Ikram, S.; Yapanis, A.; Saunders, H.; Seabra-Gomes, R.; Mendes, M.; Brizida, L.; Canada, M.; Andrade, M. J.; Lauten, A.; Oltmans, G.; Lang, A.; Schwela, H.; Machecourt, J.; Bertrand, B.; Lewis, B. S.; Merdler, A.; Halon, D. A.; Dagan, T.; Dienstl, F.; Hoertnagl, H.; Lechleitner, P.; Eiter, R.; Keren, A.; Khoury, Z.; Gabay, V.; Friart, A.; Devaleriola, Y.; Philippart, C.; McLenachan, J.; Smyllie, J.; Engelmann, L.; Duck, H. J.; Krosse, B.; Pankau, H.; Ribeiro, C.; Ferreira, R.; Correira, M. J.; Pais, F.; Araujo, A.; Monteiro, A. P.; Azevedo, J. G.; Melo, M.; Bordalo, A.; Botas, L.; St John Sutton, M. G.; Sutton, G.; Noble, M. I M; Stubbs, P.; Ramhamadamay, E.; Andre-Fouet, X.; Mulin, M. P.; Erbel, R.; Nixdorff, U.; Otterstad, J. E.; Froeland, G.; Previtali, M.; Mussini, A.; Distante A, A; Fioretti, P.; Motro, M.; Vered, Z.; Feinberg, M. S.; Shemesh, J.; Benjamin, P.; Holwerda, N.; Melman, P.; Casaccia, M.; Bottone, W.; Bellone, E.; De Bernadi, A.; Hatle, L.; Bjoernstad, K.; Askhus, S.; Hole, T.; Samstad, S.; Soma, J.; Marino, P.; Zardini, P.; Anselmi, M.; Rossi, L.; Zanolla, L.; Nidasio, G. P.; Marchandise, B.; Schroeder, E.

In: European Heart Journal, Vol. 18, No. 1, 1997, p. 31-40.

Research output: Contribution to journalArticle

Poole-Wilson, PA, Hanrath, P, Gerich, N, Flachskampf, U, De Bruyne, B, Bartunek, J, Goemaere, P, Carreras, A, Bayes de Luna, A, Schartl, M, Bocksch, W, Barkow, D, Beckmann, S, Dreysse, S, Hall, RJC, Ikram, S, Yapanis, A, Saunders, H, Seabra-Gomes, R, Mendes, M, Brizida, L, Canada, M, Andrade, MJ, Lauten, A, Oltmans, G, Lang, A, Schwela, H, Machecourt, J, Bertrand, B, Lewis, BS, Merdler, A, Halon, DA, Dagan, T, Dienstl, F, Hoertnagl, H, Lechleitner, P, Eiter, R, Keren, A, Khoury, Z, Gabay, V, Friart, A, Devaleriola, Y, Philippart, C, McLenachan, J, Smyllie, J, Engelmann, L, Duck, HJ, Krosse, B, Pankau, H, Ribeiro, C, Ferreira, R, Correira, MJ, Pais, F, Araujo, A, Monteiro, AP, Azevedo, JG, Melo, M, Bordalo, A, Botas, L, St John Sutton, MG, Sutton, G, Noble, MIM, Stubbs, P, Ramhamadamay, E, Andre-Fouet, X, Mulin, MP, Erbel, R, Nixdorff, U, Otterstad, JE, Froeland, G, Previtali, M, Mussini, A, Distante A, A, Fioretti, P, Motro, M, Vered, Z, Feinberg, MS, Shemesh, J, Benjamin, P, Holwerda, N, Melman, P, Casaccia, M, Bottone, W, Bellone, E, De Bernadi, A, Hatle, L, Bjoernstad, K, Askhus, S, Hole, T, Samstad, S, Soma, J, Marino, P, Zardini, P, Anselmi, M, Rossi, L, Zanolla, L, Nidasio, GP, Marchandise, B & Schroeder, E 1997, 'Doppler flow and echocardiography in functional cardiac insufficiency: Assessment of nisoldipine therapy. Results of the DEFIANT-II study', European Heart Journal, vol. 18, no. 1, pp. 31-40.
Poole-Wilson, P. A. ; Hanrath, P. ; Gerich, N. ; Flachskampf, U. ; De Bruyne, B. ; Bartunek, J. ; Goemaere, P. ; Carreras, A. ; Bayes de Luna, A. ; Schartl, M. ; Bocksch, W. ; Barkow, D. ; Beckmann, S. ; Dreysse, S. ; Hall, R. J C ; Ikram, S. ; Yapanis, A. ; Saunders, H. ; Seabra-Gomes, R. ; Mendes, M. ; Brizida, L. ; Canada, M. ; Andrade, M. J. ; Lauten, A. ; Oltmans, G. ; Lang, A. ; Schwela, H. ; Machecourt, J. ; Bertrand, B. ; Lewis, B. S. ; Merdler, A. ; Halon, D. A. ; Dagan, T. ; Dienstl, F. ; Hoertnagl, H. ; Lechleitner, P. ; Eiter, R. ; Keren, A. ; Khoury, Z. ; Gabay, V. ; Friart, A. ; Devaleriola, Y. ; Philippart, C. ; McLenachan, J. ; Smyllie, J. ; Engelmann, L. ; Duck, H. J. ; Krosse, B. ; Pankau, H. ; Ribeiro, C. ; Ferreira, R. ; Correira, M. J. ; Pais, F. ; Araujo, A. ; Monteiro, A. P. ; Azevedo, J. G. ; Melo, M. ; Bordalo, A. ; Botas, L. ; St John Sutton, M. G. ; Sutton, G. ; Noble, M. I M ; Stubbs, P. ; Ramhamadamay, E. ; Andre-Fouet, X. ; Mulin, M. P. ; Erbel, R. ; Nixdorff, U. ; Otterstad, J. E. ; Froeland, G. ; Previtali, M. ; Mussini, A. ; Distante A, A ; Fioretti, P. ; Motro, M. ; Vered, Z. ; Feinberg, M. S. ; Shemesh, J. ; Benjamin, P. ; Holwerda, N. ; Melman, P. ; Casaccia, M. ; Bottone, W. ; Bellone, E. ; De Bernadi, A. ; Hatle, L. ; Bjoernstad, K. ; Askhus, S. ; Hole, T. ; Samstad, S. ; Soma, J. ; Marino, P. ; Zardini, P. ; Anselmi, M. ; Rossi, L. ; Zanolla, L. ; Nidasio, G. P. ; Marchandise, B. ; Schroeder, E. / Doppler flow and echocardiography in functional cardiac insufficiency : Assessment of nisoldipine therapy. Results of the DEFIANT-II study. In: European Heart Journal. 1997 ; Vol. 18, No. 1. pp. 31-40.
@article{363e74c1952b4a0ca90eaa878e12fbba,
title = "Doppler flow and echocardiography in functional cardiac insufficiency: Assessment of nisoldipine therapy. Results of the DEFIANT-II study",
abstract = "Aims. A multicentre, double-blind, placebo-controlled trial was conducted in 542 patients, randomized 7-10 days after myocardial infarction, to study the effect of nisoldipine coat-core (nisoldipine-CC) on exercise after 6 months. Secondary endpoints included exercise-induced ischaemia, left ventricular function measured by Doppler echocardiography, adverse cardiac events and clinical outcome. Methods and results. Patients had reduced left ventricular ejection fraction between 25 and 50{\%}, but no heart failure. Exercise time was not different in the two groups. Nisoldipine-CC prolonged time to 1 mm ST deviation (P = 003). There was an effect of nisoldipine-CC of +3.6 cm.s-1 early peak velocity (P = 0.01) and of - 6.2 ms on isovolumic relaxation time (P = 0.005), but no effects on left ventricular volumes or ejection fraction. There was a trend towards reduced mortality (one death in the nisoldipine-CC group vs seven in the placebo group, P <0.07) and the combined end-point of mortality and cardiac events (P = 0.09). Peripheral oedema occurred in 49 patients assigned to nisoldipine-CC and two assigned to placebo (P <0.001). There were no differences in non-cardiac events. Conclusions. Nisoldipine-CC did not improve exercise time but increased time to 1 mm ST deviation, and improved diastolic left ventricular function. It is safe and well tolerated in post-infarction patients with impaired left ventricular function.",
keywords = "Bicycle ergometry, Calcium antagonist, Doppler echocardiography, Post-MI",
author = "Poole-Wilson, {P. A.} and P. Hanrath and N. Gerich and U. Flachskampf and {De Bruyne}, B. and J. Bartunek and P. Goemaere and A. Carreras and {Bayes de Luna}, A. and M. Schartl and W. Bocksch and D. Barkow and S. Beckmann and S. Dreysse and Hall, {R. J C} and S. Ikram and A. Yapanis and H. Saunders and R. Seabra-Gomes and M. Mendes and L. Brizida and M. Canada and Andrade, {M. J.} and A. Lauten and G. Oltmans and A. Lang and H. Schwela and J. Machecourt and B. Bertrand and Lewis, {B. S.} and A. Merdler and Halon, {D. A.} and T. Dagan and F. Dienstl and H. Hoertnagl and P. Lechleitner and R. Eiter and A. Keren and Z. Khoury and V. Gabay and A. Friart and Y. Devaleriola and C. Philippart and J. McLenachan and J. Smyllie and L. Engelmann and Duck, {H. J.} and B. Krosse and H. Pankau and C. Ribeiro and R. Ferreira and Correira, {M. J.} and F. Pais and A. Araujo and Monteiro, {A. P.} and Azevedo, {J. G.} and M. Melo and A. Bordalo and L. Botas and {St John Sutton}, {M. G.} and G. Sutton and Noble, {M. I M} and P. Stubbs and E. Ramhamadamay and X. Andre-Fouet and Mulin, {M. P.} and R. Erbel and U. Nixdorff and Otterstad, {J. E.} and G. Froeland and M. Previtali and A. Mussini and {Distante A}, A and P. Fioretti and M. Motro and Z. Vered and Feinberg, {M. S.} and J. Shemesh and P. Benjamin and N. Holwerda and P. Melman and M. Casaccia and W. Bottone and E. Bellone and {De Bernadi}, A. and L. Hatle and K. Bjoernstad and S. Askhus and T. Hole and S. Samstad and J. Soma and P. Marino and P. Zardini and M. Anselmi and L. Rossi and L. Zanolla and Nidasio, {G. P.} and B. Marchandise and E. Schroeder",
year = "1997",
language = "English",
volume = "18",
pages = "31--40",
journal = "European Heart Journal",
issn = "0195-668X",
publisher = "Oxford University Press",
number = "1",

}

TY - JOUR

T1 - Doppler flow and echocardiography in functional cardiac insufficiency

T2 - Assessment of nisoldipine therapy. Results of the DEFIANT-II study

AU - Poole-Wilson, P. A.

AU - Hanrath, P.

AU - Gerich, N.

AU - Flachskampf, U.

AU - De Bruyne, B.

AU - Bartunek, J.

AU - Goemaere, P.

AU - Carreras, A.

AU - Bayes de Luna, A.

AU - Schartl, M.

AU - Bocksch, W.

AU - Barkow, D.

AU - Beckmann, S.

AU - Dreysse, S.

AU - Hall, R. J C

AU - Ikram, S.

AU - Yapanis, A.

AU - Saunders, H.

AU - Seabra-Gomes, R.

AU - Mendes, M.

AU - Brizida, L.

AU - Canada, M.

AU - Andrade, M. J.

AU - Lauten, A.

AU - Oltmans, G.

AU - Lang, A.

AU - Schwela, H.

AU - Machecourt, J.

AU - Bertrand, B.

AU - Lewis, B. S.

AU - Merdler, A.

AU - Halon, D. A.

AU - Dagan, T.

AU - Dienstl, F.

AU - Hoertnagl, H.

AU - Lechleitner, P.

AU - Eiter, R.

AU - Keren, A.

AU - Khoury, Z.

AU - Gabay, V.

AU - Friart, A.

AU - Devaleriola, Y.

AU - Philippart, C.

AU - McLenachan, J.

AU - Smyllie, J.

AU - Engelmann, L.

AU - Duck, H. J.

AU - Krosse, B.

AU - Pankau, H.

AU - Ribeiro, C.

AU - Ferreira, R.

AU - Correira, M. J.

AU - Pais, F.

AU - Araujo, A.

AU - Monteiro, A. P.

AU - Azevedo, J. G.

AU - Melo, M.

AU - Bordalo, A.

AU - Botas, L.

AU - St John Sutton, M. G.

AU - Sutton, G.

AU - Noble, M. I M

AU - Stubbs, P.

AU - Ramhamadamay, E.

AU - Andre-Fouet, X.

AU - Mulin, M. P.

AU - Erbel, R.

AU - Nixdorff, U.

AU - Otterstad, J. E.

AU - Froeland, G.

AU - Previtali, M.

AU - Mussini, A.

AU - Distante A, A

AU - Fioretti, P.

AU - Motro, M.

AU - Vered, Z.

AU - Feinberg, M. S.

AU - Shemesh, J.

AU - Benjamin, P.

AU - Holwerda, N.

AU - Melman, P.

AU - Casaccia, M.

AU - Bottone, W.

AU - Bellone, E.

AU - De Bernadi, A.

AU - Hatle, L.

AU - Bjoernstad, K.

AU - Askhus, S.

AU - Hole, T.

AU - Samstad, S.

AU - Soma, J.

AU - Marino, P.

AU - Zardini, P.

AU - Anselmi, M.

AU - Rossi, L.

AU - Zanolla, L.

AU - Nidasio, G. P.

AU - Marchandise, B.

AU - Schroeder, E.

PY - 1997

Y1 - 1997

N2 - Aims. A multicentre, double-blind, placebo-controlled trial was conducted in 542 patients, randomized 7-10 days after myocardial infarction, to study the effect of nisoldipine coat-core (nisoldipine-CC) on exercise after 6 months. Secondary endpoints included exercise-induced ischaemia, left ventricular function measured by Doppler echocardiography, adverse cardiac events and clinical outcome. Methods and results. Patients had reduced left ventricular ejection fraction between 25 and 50%, but no heart failure. Exercise time was not different in the two groups. Nisoldipine-CC prolonged time to 1 mm ST deviation (P = 003). There was an effect of nisoldipine-CC of +3.6 cm.s-1 early peak velocity (P = 0.01) and of - 6.2 ms on isovolumic relaxation time (P = 0.005), but no effects on left ventricular volumes or ejection fraction. There was a trend towards reduced mortality (one death in the nisoldipine-CC group vs seven in the placebo group, P <0.07) and the combined end-point of mortality and cardiac events (P = 0.09). Peripheral oedema occurred in 49 patients assigned to nisoldipine-CC and two assigned to placebo (P <0.001). There were no differences in non-cardiac events. Conclusions. Nisoldipine-CC did not improve exercise time but increased time to 1 mm ST deviation, and improved diastolic left ventricular function. It is safe and well tolerated in post-infarction patients with impaired left ventricular function.

AB - Aims. A multicentre, double-blind, placebo-controlled trial was conducted in 542 patients, randomized 7-10 days after myocardial infarction, to study the effect of nisoldipine coat-core (nisoldipine-CC) on exercise after 6 months. Secondary endpoints included exercise-induced ischaemia, left ventricular function measured by Doppler echocardiography, adverse cardiac events and clinical outcome. Methods and results. Patients had reduced left ventricular ejection fraction between 25 and 50%, but no heart failure. Exercise time was not different in the two groups. Nisoldipine-CC prolonged time to 1 mm ST deviation (P = 003). There was an effect of nisoldipine-CC of +3.6 cm.s-1 early peak velocity (P = 0.01) and of - 6.2 ms on isovolumic relaxation time (P = 0.005), but no effects on left ventricular volumes or ejection fraction. There was a trend towards reduced mortality (one death in the nisoldipine-CC group vs seven in the placebo group, P <0.07) and the combined end-point of mortality and cardiac events (P = 0.09). Peripheral oedema occurred in 49 patients assigned to nisoldipine-CC and two assigned to placebo (P <0.001). There were no differences in non-cardiac events. Conclusions. Nisoldipine-CC did not improve exercise time but increased time to 1 mm ST deviation, and improved diastolic left ventricular function. It is safe and well tolerated in post-infarction patients with impaired left ventricular function.

KW - Bicycle ergometry

KW - Calcium antagonist

KW - Doppler echocardiography

KW - Post-MI

UR - http://www.scopus.com/inward/record.url?scp=8044234363&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=8044234363&partnerID=8YFLogxK

M3 - Article

VL - 18

SP - 31

EP - 40

JO - European Heart Journal

JF - European Heart Journal

SN - 0195-668X

IS - 1

ER -