Abstract
Doppler sonography measurement of portal flow velocity (PFV) after glucagon injection was performed in 45 patients with chronic hepatitis C virus (HCV) infection. Patients were divided into three groups: group 1 = no or mild liver fibrosis; group 2 = moderate to severe liver fibrosis, and group 3 = liver cirrhosis. All patients were examined using a Doppler ultrasound (US) multipurpose equipment and a convex 3.5-MHz probe, 10 min before (baseline), as well as 5 and 10 min after, IV administration of 1 mg of glucagon chloride. No significant differences were found in mean baseline PFV among group 1 (19.4 ± 2.4 cm/s), group 2 (20.1 ± 3.6 cm/s) and group 3 (17.5 ± 3.7 cm/s). Five minutes after glucagon injection, all three groups showed significantly increased values of mean PFV (25.6 ± 4.8, 23.7 ± 4.0 and 19.5 ± 5.0 cm/s, respectively; p <0.05 vs. baseline). The mean increase of PFV above baseline was significantly higher in group 1 (7.9 ± 3.7 cm/s) than in group 2 (4.5 ± 3.9 cm/s) (p <0.05) or in group 3 (2.7 ± 2.3 cm/s) (p <0.05). A significant inverse correlation was found between individual values of fibrosis score and of individual increase of PFV. In patients with chronic HCV infection, Doppler sonography measurement of PFV after glucagon injection could be useful in assessing the severity of liver histological damage.
| Original language | English |
|---|---|
| Pages (from-to) | 723-726 |
| Number of pages | 4 |
| Journal | Ultrasound in Medicine and Biology |
| Volume | 27 |
| Issue number | 5 |
| DOIs | |
| Publication status | Published - 2001 |
Fingerprint
Keywords
- Doppler sonography
- Glucagon
- HCV infection
- Portal flow velocity
ASJC Scopus subject areas
- Radiology Nuclear Medicine and imaging
Cite this
Doppler sonography measurement of portal blood flow velocity after glucagon injection in patients with chronic HCV infection. / Sereno, Silvia; Toccaceli, Fabrizio; Russo, Vincenzo; Iacomi, Fabio; Zardi, Enrico Maria; Laghi, Vittorio.
In: Ultrasound in Medicine and Biology, Vol. 27, No. 5, 2001, p. 723-726.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Doppler sonography measurement of portal blood flow velocity after glucagon injection in patients with chronic HCV infection
AU - Sereno, Silvia
AU - Toccaceli, Fabrizio
AU - Russo, Vincenzo
AU - Iacomi, Fabio
AU - Zardi, Enrico Maria
AU - Laghi, Vittorio
PY - 2001
Y1 - 2001
N2 - Doppler sonography measurement of portal flow velocity (PFV) after glucagon injection was performed in 45 patients with chronic hepatitis C virus (HCV) infection. Patients were divided into three groups: group 1 = no or mild liver fibrosis; group 2 = moderate to severe liver fibrosis, and group 3 = liver cirrhosis. All patients were examined using a Doppler ultrasound (US) multipurpose equipment and a convex 3.5-MHz probe, 10 min before (baseline), as well as 5 and 10 min after, IV administration of 1 mg of glucagon chloride. No significant differences were found in mean baseline PFV among group 1 (19.4 ± 2.4 cm/s), group 2 (20.1 ± 3.6 cm/s) and group 3 (17.5 ± 3.7 cm/s). Five minutes after glucagon injection, all three groups showed significantly increased values of mean PFV (25.6 ± 4.8, 23.7 ± 4.0 and 19.5 ± 5.0 cm/s, respectively; p <0.05 vs. baseline). The mean increase of PFV above baseline was significantly higher in group 1 (7.9 ± 3.7 cm/s) than in group 2 (4.5 ± 3.9 cm/s) (p <0.05) or in group 3 (2.7 ± 2.3 cm/s) (p <0.05). A significant inverse correlation was found between individual values of fibrosis score and of individual increase of PFV. In patients with chronic HCV infection, Doppler sonography measurement of PFV after glucagon injection could be useful in assessing the severity of liver histological damage.
AB - Doppler sonography measurement of portal flow velocity (PFV) after glucagon injection was performed in 45 patients with chronic hepatitis C virus (HCV) infection. Patients were divided into three groups: group 1 = no or mild liver fibrosis; group 2 = moderate to severe liver fibrosis, and group 3 = liver cirrhosis. All patients were examined using a Doppler ultrasound (US) multipurpose equipment and a convex 3.5-MHz probe, 10 min before (baseline), as well as 5 and 10 min after, IV administration of 1 mg of glucagon chloride. No significant differences were found in mean baseline PFV among group 1 (19.4 ± 2.4 cm/s), group 2 (20.1 ± 3.6 cm/s) and group 3 (17.5 ± 3.7 cm/s). Five minutes after glucagon injection, all three groups showed significantly increased values of mean PFV (25.6 ± 4.8, 23.7 ± 4.0 and 19.5 ± 5.0 cm/s, respectively; p <0.05 vs. baseline). The mean increase of PFV above baseline was significantly higher in group 1 (7.9 ± 3.7 cm/s) than in group 2 (4.5 ± 3.9 cm/s) (p <0.05) or in group 3 (2.7 ± 2.3 cm/s) (p <0.05). A significant inverse correlation was found between individual values of fibrosis score and of individual increase of PFV. In patients with chronic HCV infection, Doppler sonography measurement of PFV after glucagon injection could be useful in assessing the severity of liver histological damage.
KW - Doppler sonography
KW - Glucagon
KW - HCV infection
KW - Portal flow velocity
UR - http://www.scopus.com/inward/record.url?scp=0034997905&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0034997905&partnerID=8YFLogxK
U2 - 10.1016/S0301-5629(01)00347-7
DO - 10.1016/S0301-5629(01)00347-7
M3 - Article
C2 - 11397536
AN - SCOPUS:0034997905
VL - 27
SP - 723
EP - 726
JO - Ultrasound in Medicine and Biology
JF - Ultrasound in Medicine and Biology
SN - 0301-5629
IS - 5
ER -