Doppler tissue imaging: A reliable method for estimation of left ventricular filling pressure in patients with mitral regurgitation

Eustachio Agricola, Maurizio Galderisi, Michele Oppizzi, Giulio Melisurgo, Fabio Airoldi, Alberto Margonato

Research output: Contribution to journalArticle

Abstract

Background: Doppler of mitral and pulmonary vein flows are used to estimate left ventricular (LV) filling pressure. Mitral regurgitation (MR) makes unreliable these parameters by inducing changes of both mitral inflow and pulmonary vein flow. Objectives: To evaluate whether Doppler tissue imaging (DTI) diastolic indices obtained at the level of LV lateral mitral annulus can provide accurate estimation of LV filling pressure in patients with MR. Methods: Forty-three patients (age 55 ± 11 years) with severe MR and mean LV ejection fraction (EF) 58 ± 13 were enrolled, 10 (23%) with LV EF 50%. Doppler signals from the mitral inflow, pulmonary venous flow, and DTI indices of the lateral mitral annulus were obtained. LV end-diastolic pressure (LVEDP) was measured invasively with fluid-filled catheter. Results: In the overall population, the majority of standard Doppler and DTI indices correlated with LVEDP, but the multivariate analysis showed that the ratio of mitral velocity to early diastolic velocity of the mitral annulus (E/Em ratio) (β = .87, P = .0001) was independent predictor of LVEDP (R 2 = 0.74, SE = 4, P = .0001). An E/Em ratio >10 predicted an LVEDP >15 mm Hg (sensitivity 90%, specificity 83%). In both groups with LV EF >50% (β = .77, P = .005; cumulative R 2 = 0.73, SE = 2.5, P = .0001) and 2 = 0.77, SE = 2.1, P = .002), multivariate analysis underscored again only E/Em ratio as independent predictor of LVEDP. Conclusions: The combination of DTI indices of the mitral annulus and mitral inflow velocities provides reliable parameters to predict LV filling pressure in patients with MR both in patients with LV EF >50% and

Original languageEnglish
Pages (from-to)610-615
Number of pages6
JournalAmerican Heart Journal
Volume150
Issue number3
DOIs
Publication statusPublished - Sep 2005

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Mitral Valve Insufficiency
Ventricular Pressure
Stroke Volume
Blood Pressure
Pulmonary Veins
Multivariate Analysis
Catheters
Sensitivity and Specificity
Lung
Population

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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Doppler tissue imaging : A reliable method for estimation of left ventricular filling pressure in patients with mitral regurgitation. / Agricola, Eustachio; Galderisi, Maurizio; Oppizzi, Michele; Melisurgo, Giulio; Airoldi, Fabio; Margonato, Alberto.

In: American Heart Journal, Vol. 150, No. 3, 09.2005, p. 610-615.

Research output: Contribution to journalArticle

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abstract = "Background: Doppler of mitral and pulmonary vein flows are used to estimate left ventricular (LV) filling pressure. Mitral regurgitation (MR) makes unreliable these parameters by inducing changes of both mitral inflow and pulmonary vein flow. Objectives: To evaluate whether Doppler tissue imaging (DTI) diastolic indices obtained at the level of LV lateral mitral annulus can provide accurate estimation of LV filling pressure in patients with MR. Methods: Forty-three patients (age 55 ± 11 years) with severe MR and mean LV ejection fraction (EF) 58 ± 13 were enrolled, 10 (23{\%}) with LV EF 50{\%}. Doppler signals from the mitral inflow, pulmonary venous flow, and DTI indices of the lateral mitral annulus were obtained. LV end-diastolic pressure (LVEDP) was measured invasively with fluid-filled catheter. Results: In the overall population, the majority of standard Doppler and DTI indices correlated with LVEDP, but the multivariate analysis showed that the ratio of mitral velocity to early diastolic velocity of the mitral annulus (E/Em ratio) (β = .87, P = .0001) was independent predictor of LVEDP (R 2 = 0.74, SE = 4, P = .0001). An E/Em ratio >10 predicted an LVEDP >15 mm Hg (sensitivity 90{\%}, specificity 83{\%}). In both groups with LV EF >50{\%} (β = .77, P = .005; cumulative R 2 = 0.73, SE = 2.5, P = .0001) and 2 = 0.77, SE = 2.1, P = .002), multivariate analysis underscored again only E/Em ratio as independent predictor of LVEDP. Conclusions: The combination of DTI indices of the mitral annulus and mitral inflow velocities provides reliable parameters to predict LV filling pressure in patients with MR both in patients with LV EF >50{\%} and",
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T2 - A reliable method for estimation of left ventricular filling pressure in patients with mitral regurgitation

AU - Agricola, Eustachio

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AU - Oppizzi, Michele

AU - Melisurgo, Giulio

AU - Airoldi, Fabio

AU - Margonato, Alberto

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N2 - Background: Doppler of mitral and pulmonary vein flows are used to estimate left ventricular (LV) filling pressure. Mitral regurgitation (MR) makes unreliable these parameters by inducing changes of both mitral inflow and pulmonary vein flow. Objectives: To evaluate whether Doppler tissue imaging (DTI) diastolic indices obtained at the level of LV lateral mitral annulus can provide accurate estimation of LV filling pressure in patients with MR. Methods: Forty-three patients (age 55 ± 11 years) with severe MR and mean LV ejection fraction (EF) 58 ± 13 were enrolled, 10 (23%) with LV EF 50%. Doppler signals from the mitral inflow, pulmonary venous flow, and DTI indices of the lateral mitral annulus were obtained. LV end-diastolic pressure (LVEDP) was measured invasively with fluid-filled catheter. Results: In the overall population, the majority of standard Doppler and DTI indices correlated with LVEDP, but the multivariate analysis showed that the ratio of mitral velocity to early diastolic velocity of the mitral annulus (E/Em ratio) (β = .87, P = .0001) was independent predictor of LVEDP (R 2 = 0.74, SE = 4, P = .0001). An E/Em ratio >10 predicted an LVEDP >15 mm Hg (sensitivity 90%, specificity 83%). In both groups with LV EF >50% (β = .77, P = .005; cumulative R 2 = 0.73, SE = 2.5, P = .0001) and 2 = 0.77, SE = 2.1, P = .002), multivariate analysis underscored again only E/Em ratio as independent predictor of LVEDP. Conclusions: The combination of DTI indices of the mitral annulus and mitral inflow velocities provides reliable parameters to predict LV filling pressure in patients with MR both in patients with LV EF >50% and

AB - Background: Doppler of mitral and pulmonary vein flows are used to estimate left ventricular (LV) filling pressure. Mitral regurgitation (MR) makes unreliable these parameters by inducing changes of both mitral inflow and pulmonary vein flow. Objectives: To evaluate whether Doppler tissue imaging (DTI) diastolic indices obtained at the level of LV lateral mitral annulus can provide accurate estimation of LV filling pressure in patients with MR. Methods: Forty-three patients (age 55 ± 11 years) with severe MR and mean LV ejection fraction (EF) 58 ± 13 were enrolled, 10 (23%) with LV EF 50%. Doppler signals from the mitral inflow, pulmonary venous flow, and DTI indices of the lateral mitral annulus were obtained. LV end-diastolic pressure (LVEDP) was measured invasively with fluid-filled catheter. Results: In the overall population, the majority of standard Doppler and DTI indices correlated with LVEDP, but the multivariate analysis showed that the ratio of mitral velocity to early diastolic velocity of the mitral annulus (E/Em ratio) (β = .87, P = .0001) was independent predictor of LVEDP (R 2 = 0.74, SE = 4, P = .0001). An E/Em ratio >10 predicted an LVEDP >15 mm Hg (sensitivity 90%, specificity 83%). In both groups with LV EF >50% (β = .77, P = .005; cumulative R 2 = 0.73, SE = 2.5, P = .0001) and 2 = 0.77, SE = 2.1, P = .002), multivariate analysis underscored again only E/Em ratio as independent predictor of LVEDP. Conclusions: The combination of DTI indices of the mitral annulus and mitral inflow velocities provides reliable parameters to predict LV filling pressure in patients with MR both in patients with LV EF >50% and

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