Dose-dense primary chemotherapy, as part of multidisciplinary treatment, for inoperable stage III B breast cancer - Long-term results of a phase II trial

Bruno Massidda, Francesco Atzori, Antioco Scanu, Antonio Contu, Antonio Farris, Anna Maria Catino, Sergio Palmeri, Luigi Minerba, Maria Teresa Ionta

Research output: Contribution to journalArticlepeer-review

Abstract

Background: Primary chemotherapy as part of multidisciplinary approach is the established treatment for inoperable stage III B breast cancer. The primary endpoints were conversion to operable disease and feasibility of conservative surgery (breast-conserving therapy: BCT); secondary were clinical and pathological complete response rate, local and distant control and safety of the primary regimen. Methods: Between 1998 and 2001, 40 inoperable breast cancer patients ≤60 years, 72% T4abc and 28% T4d, received 6 cycles of primary PEV dose-dense regimen: cisplatin 50 mg/m 2, epirubicin 100 mg/m 2 and vinorelbine 25 mg/m 2, i.v. (q 14). Modified radical mastectomy (MRM) or BCT was performed, followed by adjuvant chemotherapy, radiotherapy and hormone therapy. Results: All patients were converted to operable disease, and BCT was feasible in 24% of T4abc patients. After a median follow-up of 84 months (range 58-96), local and distant relapses were 7.5% (0% in BCT ) and 25% (25% in BCT), respectively. Clinical response was 80% (clinical complete response [cCR]: 20%); pathological complete response (pCR) was 40% in breast, 50% in axilla (pLN0); 32% both in breast and axilla. Neutropenia (G4, 30%), leukopenia (G4, 25%), alopecia (G2, 100%), nausea and vomiting (G4, 20%) were the most common toxicities. Conclusions: The PEV dose-dense regimen seems to be highly effective in terms of resectability and pCR. Toxicity, mainly hematological, was acceptable. Successful BCT is feasible, in selected patients, without compromising local and distant control.

Original languageEnglish
Pages (from-to)17-26
Number of pages10
JournalOncology
Volume72
Issue number1-2
DOIs
Publication statusPublished - Nov 2007

Keywords

  • Breast cancer
  • Breast-conserving therapy
  • Dose-dense chemotherapy
  • Inoperable T4
  • Local-regional relapse rate
  • Primary chemotherapy

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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