Dose-dependent aversive and rewarding effects of amphetamine as revealed by a new place conditioning apparatus

Simona Cabib, Stefano Puglisi-Allegra, Carmela Genua, Herve Simon, Michel Le Moal, Pier Vincenzo Piazza

Research output: Contribution to journalArticlepeer-review

Abstract

Amphetamine-induced place conditioning was evaluated in mice using a newly designed apparatus. It was demonstrated that this apparatus provides a neutral set of cues devoid of rewarding or aversive properties and can reveal place preference or aversion after pairings with drugs (amphetamine and morphine for preference and naloxone for aversion) known to produce such effects. Moreover, repeated pairings of environmental cues with either 2 or 3 mg/kg d-amphetamine resulted in significant conditioned place preference on a drug free test, whilst repeated pairings with a lower dose of the drug (1 mg/kg) resulted in significant conditioned place aversion, Finally, a small number of mice showed opposite responses in comparison with group means at low as well as at high doses of amphetamine. These results suggest that amphetamine may promote conditioned place preference or avoidance depending on dosage and individual susceptibility.

Original languageEnglish
Pages (from-to)92-96
Number of pages5
JournalPsychopharmacology
Volume125
Issue number1
DOIs
Publication statusPublished - 1996

Keywords

  • Amphetamine
  • Aversion
  • Drugs of abuse
  • Individual differences
  • Morphine
  • Naloxone
  • Place avoidance
  • Place preference
  • Reward

ASJC Scopus subject areas

  • Pharmacology

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